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Homology model and docking based virtual screening for ligands of human dyskerin as new inhibitors of telomerase for cancer treatment

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Academic year: 2020

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Figure 1. Graphical representation of the abundance of the 20 amino acids (aa) present in human  dyskerin pseudouridine synthase (hDKC1)
Figure 2. Secondary structure prediction of hDKC1 using HHPred (SPIDER2 (Scoring Protein  Interaction Decoys using Exposed Residues) for secondary structure prediction, and DISOPRED  (Disorder Prediction Server) for unstructured or disordered region predic
Figure 5. PROCHECK (Program to check the stereochemical quality of protein structures) results of  modelled hDKC1 using the generated models from I-TASSER
Figure 6. Analysis of mutation stability in the hDKC1 model by Foldx software. Mutations comprised  between red dashes lines (−0.5 Kcal/mol to 1.5 Kcal/mol) correlates with the mutations that are not  destabilizing
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