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Liver specific ablation of insulin degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice

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Figure

Fig. 1. Analysis of IDE expression in WT and L-IDE-KO mice. (A) Expression of Ide mRNA in 3-month-old male L-IDE-KO and control littermates
Fig. 2. Metabolic features of L-IDE-KO mice. Fasting (A) and non-fasting (B) blood glucose levels in 3-month-old male WT and L-IDE-KO mice
Fig. 3. L-IDE-KO mice exhibit impaired glucose homeostasis and insulin resistance. (A) IP-GTT of 3-month-old male mice
Fig. 6. Effects of Ide deletion on gluconeogenesis and glycogenesis. (A) Subcellular distribution of basal and insulin-stimulated FoxO1 in L-IDE-KO and WT mice
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