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Immunization with a recombinant bacillus calmette guérin strain confers protective Th1 immunity against the human metapneumovirus

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Academic year: 2020

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FIGURE 1. Expression of hMPV-P and M2-1 proteins by rBCG strains. BCG was electrotransformed with plasmid pMV361-P or pMV361-M2-1 and selected on solid 7H10 medium supplemented with 20 mg/ml kanamycin
FIGURE 2. Immunization with rBCG-hMPV strains protect mice from hMPV-induced lung pathology
FIGURE 4. Immunization with rBCG-P-hMPV reduces histopathology damage in the lungs after hMPV infection
FIGURE 5. Immunization with rBCG-P-hMPV decreases the recruitment of CD4 + and CD8 + T cells in the lung upon hMPV infection
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