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Leptolide improves insulin resistance in diet induced obese mice

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Academic year: 2020

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Figure  1.  Leptolide  augments  insulin  signaling  in  HepG2  cells.  Western  blot  analysis  of  PKB  and    p‐PKB in HepG2 cells treated with leptolide (0.1 μM) or vehicle and stimulated with 100 mM insulin  for 5, 10, 15 and 30 min. Leptolide action 
Figure  2.  Leptolide  prevents  palmitate‐induced  insulin  resistance  in  HepG2  cells.  Western  blot  analysis of PKB and p‐PKB in HepG2 cells treated with leptolide (0.1 μM) or vehicle, in the presence  or absence of palmitate. Cells were stimulated 
Figure 3. Acute leptolide administration improves glucose tolerance and insulin sensitivity in lean mice.
Figure 4. Prolonged leptolide administration improves insulin sensitivity in a preclinical model of  insulin resistance. C57BL6J male mice were fed an HFD for ten weeks. The last four weeks, mice were  injected  intraperitoneally  with  leptolide  or  sali
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