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Role of Sirt1 During the Ageing Process: Relevance to Protection of Synapses in the Brain

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Academic year: 2020

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Figure

Fig. 1 Sirtuin enzymatic activities. Sirtuins are NAD + -dependent his- his-tone deacetylases which carry out several deacetylation and  ADP-ribosylation reactions
Fig. 4 Sirt1 protects rat hippocampal neurons against A β challenge.
Fig. 5 a Effect of resveratrol or NAD + on cell viability measured by MTT assays. a Hippocampal neurons were treated with different A βo concentrations for 24 h (black circles) or preincubated with 20 μM resveratrol for 2 h (white circle) or 2 mM of NAD +
Fig. 6 Neuronal effects derived from Sirt1 activation. The in vitro activation of Sirt1 by either NAD + or resveratrol, or overexpression of Sirt1, induces several cellular mechanisms which lead to increased neuronal survival and protection of the neuronal

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