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Increased copper levels in in vitro and in vivo models of Niemann Pick C disease

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Fig. 1 Copper content is correlated with cholesterol accumu- accumu-lation in a human hepatoma NPC model cell line
Fig. 2 Copper content in U18666A-treated primary hippocam- hippocam-pal neurons. Rat hippocamhippocam-pal neuron primary cultures treated with U18666A (U18) (1 lg/mL) for the last 2 h, in the presence or absence of Cu:His complexes (1:10) 5 lM copper for 2
Fig. 4 Ceruloplasmin levels in the plasma of Npc1 -/- mice.

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