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Human conditions of insulin like growth factor I (IGF I) deficiency

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Figure 1 Schematic structures of IGFs and their receptors. Resemblances between Insulin and IGFs allow them to cross-interactions by which IGFs are able to bind to their own receptors (preferently) but also to Insulin receptor (IR) with a lower specificity
Figure 2 GH/IGF-I axis and targets. Pituitary GH interacts with GH receptors in hepatocytes increasing IGF-I secretion for endocrinological purposes in different organs, although an autocrine/paracrine IGF-I production by those organs is also present.
Figure 3 Lifelong beneficial properties of IGF-I. Evolution of IGF-I circulating levels and its pluripotent roles along different stages of human development and aging.
Figure 4 IGF-I receptor pathway. Activation of IGF-IR leads to a cascade of related molecules involved in previously described actions of IGF-I (survival, cell growth and differentiation, cytoprotection, glucose metabolism, etc).
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