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Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response

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Academic year: 2020

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Fig. 1. Chronic stress accelerated DSS-induced colitis. (A) Body weight of mice in normal and stress groups before DSS and immobility time of mice after 1 mo stress in TST and FST using an EthoVision XT 11.5 system (n = 10)
Fig. 2. Chronic stress disturbed the immune system. (A) Flow cytometric analysis of B cells (CD45 + , CD19 + ), NEUs (CD45 + , Ly6G + ), and ly6c hi macrophages in colonic lamina propria (n = 4–5)
Fig. 3. Genetic deletion of IL-6 failed to terminate the effect of chronic stress.(A) Body weight before DSS and body weight at the time of  eutha-nasia (n = 5)
Fig. 4. Chronic stress changed composition of gut microbiota and degraded the colonic mucus barrier
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