A cytoplasmic PPPSP motif determines Megalin's phosphorylation and regulates receptor's recycling and surface expression

Surprisingly, after 6 days of treatment B cells survival was better when cells were treated with HIV-1, with CD40L/IL-4 or with LPS/IL-4 where an average of 40–60% of living B cells

rapid and irreversible death of infected cells. This early shut-off of host translation by eIF2a phosphorylation in SINV-infected cells could also suppress the synthesis of IFN and

In the present work, we describe DYRK2 as a new kinase that regulates NOTCH1 pathway via phosphorylation, con- trolling its protein levels and activity in response to DNA

Importantly, silencing of endogenous HIF2 a resulted in a marked repression of mTORC1 activity and SLC7A5 expression in 786-O VHL-deficient cells when cells were cultured

Now we also show that this upregulation occurs in H35 cells and acute liver injury, two conditions with different levels of Mat1a (minute or strongly reduced) and Mat2a expression

NP-MVE concentrations of 2 and 1 mg/ml resulted to be cytotoxic per se, as shown in Figure 3, A and B and were not able to ameliorate CDDP cytotoxic effect even if cells were

HCT116 cells were incubated with H89 or db-cAMP or were left untreated prior to mitochondrial extraction to study the effect of IF1 phosphorylation on the hydrolase and

Human cancer cells show predominant expression of NANOGP8, whereas pluripotent cells (embryonic stem cells and embryonal carcinoma cells) express the NANOG variant