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Formulation development and Optimization of Diclofenac Sodium Extended release Matrix tablets as per USP standards

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Table 1: Master formula of Matrix tablet   Ingredients/ 1 Tablet M1(mg) M2 (mg) M3(mg) M4(mg) M5(mg) M6(mg) M7(mg) M8(mg) Diclofenac sodium  100 HPMC K4M 50 100 150 200 - - -  -HPMC K15 M - - - - 50 100 150 200 Magnesium stearate 2 Talc 3
Table 2: Physicochemical parameters of developed matrix tablets Formulation  code Hardness a(kg/cm2) Friability (%) Thicknessa(mm) Weight a(mg) Drug content a (%) M1 M2 M3 M4 M5 M6 M7 M8 7.320±0.17.299±0.17.47±0.097.47±0.09 7.48±0.0917.48±0.0997.73±0.0967.
Table 4: Comparison of release profile of USP Diclofenac sodium extended release tablets  with optimized formulation 15 .

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