A- Knowledge and Understanding

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Course Specification

University: Minia Faculty of Pharmacy

Department: Medicinal Chemistry 1- Administrative Information Course Title:

Medicinal Chemistry-3

Code: PC519 Academic Year/level: Fifth Year.

(first term) Department(s) offering the course:

Medicinal chemistry

Lecture: 2 hrs/week Total = 24 hrs (12 weeks) Tutorial: 2 hrs (1 week) Practical: 2 hrs/week Total = 26 hrs (13 weeks) Total: 52 hrs

2- Aims (Module purpose)

Introduce the fundamental principles of drugs acting on different systems (CNS and ANS) and gain the knowledge about the group of local anesthetics, thyroid & antithyroid drugs, prostaglandins vitamins, and oral hypoglycemic.

3- Overall aims of Course:

A- Knowledge and Understanding

By the end of this course, the student should be able to:

A1- Memorize an adequate background about drug classes acting on different systems of the body (CNS and ANS), mechanisms of action, and synthesis.

A2- Describe principles of medicinal chemistry including physicochemical properties, and metabolism of various drugs.

A3- Understand the structure activity relationship of various drugs like local anesthetics, thyroid & antithyroid drugs, prostaglandins vitamins, and oral hypoglycemic.

A4- Memorize different methods for drug analysis according to functional groups.

B- Intellectual Skills:

B1- Apply qualitative and quantitative analytical and biological methods on assay of raw materials and pharmaceutical

preparations.

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B2- Evaluate various methods of identification and standardization of active substances from their formulations.

B3- Use chemical knowledge for professional problem solving B4- Interpret useful data obtained from text books, periodicals and internet.

B5- Predict the potential activity of the chemical agent from its structure.

C- Professional and Practical Skills:

C1- Practice different lab safety measures.

C2-Work with guidance on lab instruments (such as UV-Vis spectrophotometer, HPLC and Spectroflorometer).

C3- Select the appropriate methods of synthesis, purification, identification, and standardization of active substances from different origins.

C4- Construct appropriate plans for research projects.

C5- Differentiate between different groups of drugs.

D- General and transferable skills:

D1-Retrieve and evaluate information from different resources.

D2- Update his scientific background D3- Acquire the skills of project managing

D4- Communicate effectively by all types of effective communication

4- Course Contents:

Weeks Lecture

(hrs) Practical

(hrs) Total No.

of hrs Topic

3 6

Autonomic Nervous System and

6

Autonomic Drugs

2 4

Vitamins

4

1 2

C.N.S Stimulants

2

2.5 5

C.N.S depressants

5

1.5 3

Oral Hypoglycemic

3

0.5 1

Thyroids and antithyroid

1

0.5 1

Prostaglandins

1

1 2

Local Anesthetics

2

1 2hrs

Tutorial

2 1 2

Assay of Dexamethasone Ampules (BP 1980) Practical

1 2 2

Assay of Propranolol

(3)

HCl tablets (BP 1998)

1 2 2

Assay of Vitamin C by Iodometric assay (BP 1998)

1 2 2

Assay of Vitamin C by cerric ammonium sulfate method (BP 1998)

1 2 2

Assay of Metformin (BP 1998)

1 2 2

Assay of Ketoprofen tablets (BP 1998)

1 2 2

Assay of Cough mixture (Cid Company)

1 2 2

Assay of vitamin B12

ampules (BP 1998)

1 2 2

Assay of Thiamine HCl (BP 1998)

1 2 2

Assay of Imipramine HCl tablets (BP 1993)

1 2 2

Assay of Allopurinol tablets (BP 1993)

1 2 2

Assay of Chloralhydrate syrup (BP 1993)

1 2 2

Practical Exam

13 26

52 26 Total

Matrix I- Coverage of the course ILOs by different topics

D- General and transferable skills

C- Professional and practical skills:

B- Intellectual Skills:

A- Knowledge and Understanding

Topics

D4 D3 D D2

C5 1 C4 C3 C2 B C1

B4 5 B B3

B1 2 A4 A3 A2 A1

●

● Autonomic

Nervous System and Autonomic

Drugs

●

● Vitamins

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●

● C.N.S Stimulants ●

●

● C.N.S depressants ●

●

● Oral Hypoglycemic

●

● Thyroids and ●

antithyroid

●

● Prostaglandins ●

●

● Tutorial

●

● Practical lessons

5- Teaching and Learning Methods:

Lecture: Computer, data show, white board, marker

Practical: White board, marker, laboratory chemicals, laboratory glassware, UV spectrophotometer

Matrix II- Coverage of the course ILOs by different learning methods

general and -

D

s

transferable skill C- Professional and practical

skills:

B- Intellectual skills:

Knowledge and -

A

Understanding

Teaching and learning

method

D4 D3 D2 C5 D1

C3 C4 C2 C1 B5 B4 B3 B2 A4 B1

A3 A2 A1

●

● Lecture ●

●

● ●

● Tutorial ●

● ●

●

● ●

●

● ●

●

● ● Practical

lessons

Matrix III- Measuring the achievement of the course ILOs by different assessment methods

general and -

D

s

transferable skill C- Professional and practical

skills:

B- Intellectual skills:

Knowledge and -

A

Understanding

Teaching and learning

method

D4 D3 D2 C5 D1

C3 C4 C2 C1 B5 B4 B3 B2 A4 B1

A3 A2 A1

●

● ●

●

● Written ●

●

● ●

● Oral ●

● ●

●

● ●

●

● ●

●

● ● Practical

6- Student Assessment:

6.1 Written examination to assess the ability of student to understand the theoretical courses.

6.2 Oral examination to assess the ability of student to explain and solve problems.

6.3 Practical examination to assess the ability of student to deal with practical problems

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7- Assessment Schedule:

Written exam : 14^th , 15^th weeks Practical exam: 13^th, week Oral exam: 14^th , 15^th,weeks

8- Weighting of Assessment:

Mid term exam 6.6% (10 marks) written exam 53.3% (80 marks) practical exam 26.6% (40 marks) oral exam. 13.3% (20 marks) Total 100% (150 marks) 9- List of

References:

1. Foye, W. O. (2008). Foye's principles of medicinal chemistry. T. L.

Lemke, & D. A.Williams (Eds.). Lippincott Williams &Wilkins. 10th chapter

2. Beale, J. M., Block, J., & Hill, R.(2010). Organic medicinal and pharmaceutical chemistry. Philadelphia:Lippincott Williams &

Wilkins. 3rd chapter

3. David A. Williams, Thomas L. Lemke, Foye’s Principles of Medicinal Chemistry, 7^th edn, Lippincott Williams & wilkins, Baltimore (2013).

4. Camille G. Wermuth, The Practice of Medicinal Chemistry, Academic Press (1996).

5. Gareth Thomas, Fundamentals of Medicinal Chemistry, by John Wiley

& Sons Ltd, 2003.

A- Course Notes Prepared by the staff members of the Medicinal Chemistry Department, Faculty of Pharmacy, Minia University

B- Essential Books:

C-

Recommended Books:

1. David A. Williams, Thomas L. Lemke, Foye’s Principles of Medicinal Chemistry, 7^th edn, Lippincott Williams & wilkins, Baltimore (2013).

2. Jame N. Delgado and William A. Remers, Wilson and Gisvold;s text book of Organic, Medicinal and Pharmaceutical Chemistry, 12^th edn, Lippincott Ravan, Philadelphia (2004).

3. Manfred E. Wolf, Burger’s Medicial Chemistry and Drug Discovery, 6^th edn, volume 1, John Awiley & Sons Inc., New York (2003).

4. Camille G. Wermuth, The Practice of Medicinal Chemistry, Academic Press (1996).

5. Gareth Thomas, Fundamentals of Medicinal Chemistry, by John Wiley &

Sons Ltd, 2003.

6. Graham L. Patrick, An Introduction to Medicinal Chemistry, Oxford New York Tokyo, 2008.

D- Periodicals, Web sites, etc.

Course Coordinator:

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Prof. Dr. Mohamed Abdel Aziz Mohamed

Head of Department

^:

A- Knowledge and Understanding

Course Specification

2- Aims (Module purpose)

3- Overall aims of Course:

A- Knowledge and Understanding

B- Intellectual Skills:

C- Professional and Practical Skills:

D- General and transferable skills:

4- Course Contents:

Autonomic Nervous System and

Autonomic Drugs

Vitamins

C.N.S Stimulants

C.N.S depressants

Oral Hypoglycemic

Thyroids and antithyroid

Prostaglandins

Local Anesthetics

1 2 2

1 2 2

1 2 2

1 2 2

1 2 2

Matrix I- Coverage of the course ILOs by different topics

Matrix II- Coverage of the course ILOs by different learning methods

Matrix III- Measuring the achievement of the course ILOs by different assessment methods

7- Assessment Schedule:

8- Weighting of Assessment:

Course Coordinator:

Prof. Dr. Mohamed Abdel Aziz Mohamed

Head of Department

Dr.Eman Ahmed Mahmoud Beshr