Academic year (2019/2020)
Course specifications (2019/2020)
University: Minia Faculty of Pharmacy
Department: Pharmacology and Toxicology 1- Administrative Information
Course Title:
Bioassay and Biostatistics
Code:
(PO425)
Academic Year/level:
4th year- 2016 ةحئلا Department(s) offering the course:
Pharmacology and Toxicology
Lecture: 2hrs/week (X15 week= 30hrs/ semester) Tutorial: … .
Practical: 2 hrs/week (x15week 30 hrs/ semester) Total: 60 hr/semester
2- Aims
(Module purpose)
To provide basic information about principles of screening and bioassay.
To provide expertise in predicting and evaluating the pharmacological effects of new compounds.
To acquire necessary knowledge about biological variation.
To provide essentials of biostatistics and its application in biology.
3- Overall aims of Course:
A- Knowledge and Understanding
A-1: Understand the difference between biological assay and screening.
A-2: Identify the sources of biological variability and methods of reducing it.
A-3: Recognize the principles of biological assays of different drug categories.
B- Intellectual Skills:
B-1: Evaluate raw materials and pharmaceutical products using suitable quantitative and qualitative techniques.
B-2: Assess the biological activity of drugs based on their pharmacological and biological properties.
B-3: Practice some laboratory techniques to be able to perform pharmacological experiments.
B-4: Apply appropriate computer skills to use biostatistics in biological assays.
C- Professional and Practical Skills:
C-1: Utilize principles of biostatistics in the biological evaluation of new compounds.
C-2: Assess the activity of new compounds on the different body systems.
C-3: Construct appropriate plans for biological evaluation of new compounds C-4: Apply different qualitative and quantitative procedures for evaluation of chemical, herbal and biological products.
D- General and transferable skills:
D-1: Proceed communication effectively both orally and in writing, at an appropriate level, utilizing information technology to perform biostatistics.
D-2: Show initiative, manage resources, solve problems and work effectively both independently and as part of a team.
D-3: Identify personal learning needs and update the scientific background frequently.
D-4: Use mathematical calculations and statistics programs.
4- Course Contents:
Lecture Practical
No. of hours Topic
2hr /w 4hr
Introduction to biostatistics, bioassay and screening
2hr /w 4 hr
Blind screening
Neuropharmacological tests
Cardiovascular tests and cat nictitating membrane
2hr /w 4 hr
Screening of autonomic activity Screening of sympathetic activity Screening of parasympathetic activity
2 hr /w 4 hr
Screening of cardiovascular drugs Screening of antihypertensive activity
Screening of antiarrhythmic, digitalis like activity and antianginal activity
2hr /w 4 hr
Screening of CNS activity
2hr /w 4 hr
Screening of Hormonal activity
2hr /w 12 hr
Principles of biostatistics
2hr /w 4 hr
Screening of analgesics activity (practical)
2hr /w 2 hr
Screening of drugs in asthma (practical)
2hr /w 6 hr
Screening of NMBs (practical)
6- Student Assessment:
Assessment Methods:
Written examination to assess the ability of student to understand the theoretical courses.
Oral examination to assess the ability of student to explain and solve problems.
Practical examination to assess the ability of student to deal with practical 5- Teaching and
Learning Methods:
Lecture: Computer, data show, white board, marker
Practical: White board, marker, and laptops and computers, experimental animals, hot plate, motor activity cage, kymographs.
Matrix I- Coverage of the course ILOs by different topics
General and -
D
sferable skills tran
Professional and -
C
practical skills Intellectual
- B
skills:
Knowledge -
A and Understanding
Topics
D4 D3 D2 D1 C4 C3 C2 C1 B4 B3 B2 B1 A3 A2 A1
●
●
●
●
●
●
●
●
● Introduction to biostatistics,
bioassay and screening
●
●
●
●
● Blind screening
Neuropharmacological tests Cardiovascular tests and cat nictitating membrane
●
●
●
●
●
●
● Screening of autonomic activity ●
Screening of sympathetic activity Screening of parasympathetic activity
●
●
●
●
●
●
●
●
●
● Screening of cardiovascular drugs ●
Screening of antihypertensive activity
Screening of
antiarrhythmic, digitalis like
activityand antianginal activity
●
●
●
●
●
●
●
●
●
● Screening of CNS activity ●
●
●
●
●
●
● Screening of Hormonal activity ●
●
●
●
●
●
●
● Principles of biostatistics ●
●
●
●
●
●
● Screening of analgesics ●
activity (practical)
●
●
●
●
●
● Screening of drugs in asthma ●
(practical)
●
●
●
●
●
● Screening of NMBs (practical) ●
Oral: 15th week Weighting of
Assessment:
Term written exam. 53.3%
Midterm exam 0.7%
Practical exam. 26.7%
Term oral exam. 13.3%
Total 100%
Matrix II- Coverage of the course ILOs by different learning methods
General and -
D
transferable skills Professional and
- C
s practical skill Intellectual skills:
- B Knowledge and -
A
Understanding
Topics
D4 D3 D2 D1 C4 C3 C2 C1 B4 B3 B2 B1 A3 A2 A1
●
●
●
●
●
●
●
●
● Lecture
●
●
●
●
●
●
●
●
●
●
●
● Practical lessons ●
Matrix III- Measuring the achievement of the course ILOs by different assessment methods
General and -
D
transferable skills Professional and
- C
practical skills Intellectual skills:
- B Knowledge and -
A
Understanding
Topics
D4 D3 D2 D1 C4 C3 C2 C1 B4 B3 B2 B1 A3 A2 A1
●
●
●
●
●
●
●
● Written ●
●
●
●
●
●
●
●
●
●
●
●
● Practical lessons ●
●
●
●
●
●
●
● Oral
7- List of references:
A- Course Notes Power point handouts prepared by staff members of the department, Faculty of pharmacy, Minia University
B- Essential Books:
Drug Discovery and Evaluation: Pharmacological Assays. Springer International Publishing Switzerland 2016
C-Recommended Books:
Drug Discovery and Evaluation: Pharmacological Assays. Springer International Publishing Switzerland 2016
D- Periodicals, Web sites, etc.
Course Coordinator:
Dr. Al-Shaimaa Faissal Fadel Ahmed
Prof Dr. Gehan H. Heeba
