Academic Year 2020/2021 Course Specification
University: Minia Faculty of Pharmacy
Department: Medicinal Chemistry
Administrative Information -
1
Course Title:
Medicinal Chemistry I
Code: PC709 Academic Year/level:
Semester 7, Clinical Pharmacy Programme
Department(s) offering the course: Medicinal chemistry
Lecture: (2 hours/ week) Total: 24 hours.
Tutorial: (2 hours/semester) Total: 2 hours Practical: (2 hours/week) Total: 26 hours Total: 52 hours
2- Aims (Module purpose) Understand the fundamental principles of drugs acting on autonomic nervous system and other classes of drugs such as antibacterial, antifungal, antiviral, antiprotozoal and antineoplastic agents and acquire knowledge about the principles of drug design and metabolism.
Overall aims of Course:
- 3
A- Knowledge and Understanding
By the end of this course, the student should be able to:
A1- Memorize an adequate background about drug classes acting on different systems of the body, mechanisms of action, preparation methods, and methods for their evaluation A2- Describe different metabolic pathways in the human body and methods to diagnose specific related diseases
A3- State general principles of drug design.
A4- Understand the structure activity relationship of different classes of drugs
B- Intellectual Skills: B1- Apply qualitative and quantitative analytical and biological methods on assay of raw materials and pharmaceutical preparations.
B2- Use chemical knowledge for professional problem solving.
B3- Interpret useful data obtained from text books, periodicals and internet.
B4- Predict the potential activity of the chemical agent from its structure.
B5- Recognize possible receptors and enzymes as sites for drug action.
C- Professional and Practical Skills:
C1- Practice with different laboratory safety measures.
ةلديصلا ةيلك
C2- Use different laboratory glassware and techniques used for drug assay.
C3- Use pharmacopeia and some special laboratory instruments (such as UV-Vis spectrophotometer) in identification
and assay of drugs.
C4- Predict different metabolic pathways in addition to different strategies for drug design.
D- General and transferable skills:
D1- Update the scientific background.
D2- Retrieve and evaluate information from a variety of sources.
D3- Work effectively within a team.
4- Course Contents:
Week Lecture
(hrs) Practical
(hrs) Total No.
of hours Topic
2 4
4
Antibiotics
0.5 1
1
Sulphonamides
0.5 1
1
Antitubercular Drugs
1 0.5 1
Antifungal Agents
1 0.5 1
Antiprotozoal Agents
1 0.5 1
Antimalarial Agents
1 0.5 1
Anthelmintic Agents
1 0.5 1
Antiviral Agents
1 2
2
Antineoplastic Agents
1 0.5 1
Urinary Tract Antiseptics
1 0.5 1
General Antiseptics
2 4
4
Drug Metabolism
0.5 1
1
Drug Design
0.5 1
1
Antihistamines
1.5 3
3
Autonomic nervous system
4
2
Pharmacopea
4
2
Assay of H2O2 (using KMnO4 and Iodine) BP1998
1
Assay of Povidone iodine BP1998 2
1
Assay of Eye drops (Cid company) 2
2
1
Assay of Isoniazide tablets BP1998
2
1
Assay of Streptomycin sulphate vials BP1998
1
Assay of Benzyl Penicillin Vials 2
2
1
Assay of Frusemide tablets BP1998
3
Applications about drug metabolism and drug 6 design
2
Tutorial
26
24 52
Total
Matrix I- Coverage of the course ILOs by different topics
General -
D and transferable
s skill -
C Professional and practical
skills:
Intellectual -
B
skills:
Knowledge and -
A
understanding
Topics
D3 D2 C4 D1
C3 C2 B5 C1
B3 B4 B2 A4 B1
A3 A2 A1
●
●
●
●
●
● Antibiotics ●
●
●
●
●
●
● Sulphonamides ●
●
●
●
●
●
● Antitubercular ●
Drugs
●
●
●
●
●
● Antifungal Agents ●
●
●
●
●
●
● Antiprotozoal ●
Agents
●
●
●
●
●
● Antimalarial Agents ●
●
●
●
●
●
● Anthelmintic ●
Agents
●
●
●
●
●
● Antiviral Agents ●
●
●
●
●
●
● Antineoplastic ●
Agents
●
●
●
●
●
● Urinary Tract ●
Antiseptics
●
●
●
●
●
● General Antiseptics ●
●
●
●
●
●
● Drug Metabolism ●
●
●
●
●
●
●
● Drug Design ●
●
●
●
●
●
● Antihistamines ●
●
●
●
●
●
● Autonomic nervous ●
system
●
●
●
●
● Pharmacopea ●
●
●
● ●
● ●
●
● ● Assay of H2O2
(using KMnO4 and Iodine) BP1998
●
●
● ●
● ●
●
● ● Assay of Povidone
iodine BP1998
●
●
● ●
● ●
●
● ● Assay of Eye drops
(Cid company)
●
●
● ●
● ●
●
● ● Assay of Isoniazide
tablets BP1998
●
●
● ●
● ●
●
● ● Assay of
Streptomycin sulphate vials BP1998
●
●
● ●
● ●
●
● ● Assay of Benzyl
Penicillin Vials
●
●
● ●
● ●
●
● ● Assay of Frusemide
tablets BP1998
●
●
● ●
● ●
●
● ● Applications about
drug metabolism and drug design
●
●
●
●
●
●
●
●
●
●
●
Tutorial
●Matrix II- Coverage of the course ILOs by different learning methods
General -
D and transferable
s skill -
C Professional and practical
skills:
Intellectual -
B
skills:
Knowledge and -
A
understanding
Teaching and learning method
D3 D2 C4 D1
C3 C2 B5 C1
B3 B4 B2 A4 B1
A3 A2 A1
●
●
●
●
●
●
●
●
●
● Lecture ●
●
●
●
●
●
●
●
●
●
●
●
● Practical lessons ●
●
●
●
●
●
●
●
●
●
●
●
● Tutorial ●
Matrix III- Coverage of the course ILOs by different assessment methods
General -
D and transferable
s skill -
C Professional and practical
skills:
Intellectual -
B
skills:
Knowledge and -
A
understanding
Assessment methods
D3 D2 C4 D1
C3 C2 B5 C1
B3 B4 B2 A4 B1
A3 A2 A1
●
●
●
●
●
●
●
●
●
●
●
Written
●●
●
●
●
●
●
●
●
●
Oral
●●
●
●
●
Practical
●5- Teaching and 1- Lecture
Learning Methods:
Computer, data show, white board, marker.
2- Practical
White board, marker, laboratory chemicals, laboratory glassware, UV spectrophotometer, HPLC and Spectroflorometer.
3- Tutorial
Computer, data show, white board, marker.
6- Teaching and Learning
Methods: to Students with Limited Capacity 7- Student Assessment:
Student Assessment Methods:
7.1 Written examination to assess the ability of student to understand the theoretical courses.
7.2 Oral examination to assess the ability of student to explain and solve problems.
7.3 Practical examination to assess the ability of student to deal with practical problems
Weighting of Assessment:
Assessment 1: Midterm exam at 7th week.
Assessment 2: Practical exam in the 13th week.
Assessment 3: Sheet in the 13th week.
Assessment 4: Written exam in the 14th and 15thweek.
Assessment 5: Oral exam in the 14th and 15th week.
Mid term exam. 10 % (10 marks) Practical exam. 25 % (25 marks) Oral exam. 15 % (15 marks) Written exam. 50 % (50 marks) Total 100% (100 marks) - List of References:
A- Course Notes B- Essential Books:
C-
Recommended Books:
1. David A. Williams, Thomas L Lemke, Foye's Principles of Medicinal Chemistry, 7th edn, Lippincott , Williams & wilkins, Baltimore (2013).
2. Jame N. Delgado and William A Remers. Wilson and Gisvold. Textbook of Organic, .Medicinal and Pharmaceutical Chemistry, 10th ed, lippincott Ravan, Philadelphia (1998).
3. Manfred E~ Wolf; Burger's Medicinal Chemistry and Drug Discovery, 5th ed, , John Wiley& Sons Inc., New York (1997).
4. Andreas Korlokovas. Essentials of Medicinal Chemistry, 2ed edn. a willey Interscience Publication, New York (1988)
5. Camille G. Wermuth, The Practice of Medicinal Chemistry, Academic Press (1996).
6. A. Kleemann and G. Engel, Pharmaceutical Substances, 3''1 ed, George Thieme Verlage, Stuttgart (1999).
7. A R. Gennaro, Reminglon: The science and Practice of Pharmacy, 19th ed.
, Mack Publishing company, Easlon, Pennsylvania (1995)
8. J.G. Hardmann, L. E. limbird, A Goodman Gilman, Eds Goodman &
Gilman's The Pharmacological Basis of Therapeutics, 10'" Ed n.; McGraw Hill: New York (2001).
9. The British Pharmacopoeia 1998.
10. The USP. Nf, XXII 1990.
D- Periodicals, Web sites, etc.
Course Coordinator:
Prof. Dr. Eman Ahmed Mahmoud Beshr
Head of Department:
Prof. Dr. Eman Ahmed Mahmoud Beshr