Executive Summary 4

In addition, 45.1% of articles are published in journals in the top 25 percent (first quartile) of their field. In addition, 24.3% of originals published in 2011 were in journals in the top ten percent of their field, and 47.0% in first-quartile journals.

Distribution of the manuscripts

Quartile 1 Quartile 2 Quartile 3 Quartile 4 Non indexed

Impact factor and citation index

Analysis by Research Area

IF distibution by area

Collaboration analysis

Other activities

GOVERNING COUNCIL

RESEARCH COMMITTEE

Research Structure

CLINICAL RESEARCH

COMMITTEE

ANIMAL

WELFARE ETHICS COMMITTEE

ASSURANCE COMMITTEE

TRAINING COMMITTEE

DOCUMENTATION SERVICE

Neuroscience Area Coordinator: Exuperio Díez Tejedor

Cardiovacular Area

RESEARCH AREAS

Infectious Diseases and Inmunity Area Coordinator: José Ramón Arribas López

Large System Pathology Area Coordinator: Francisco García Río

Cancer and Human Molecular Genetics Area Coordinator: Jaime Feliu Batlle

Surgery, Transplant and Health Technologies Area Coordinator: Juan Antonio Tovar Larrucea

PUBLIC RESEARCH CONTRACTS

2011 DATA: HUMAN RESOURCES

CONTRACTS

TOTAL ESTABLISHED + PROGRAMMES + FELLOWS 51

The fundamental objective of the IdiPAZ training plan is to increase the understanding of the areas of interest to its researchers, offering not only the activities carried out by HULP (Continuing Education) and UAM (Postgraduate), but also the Institute's courses, which are pre-selected based on the identified needs of IdiPAZ members. The Institute's support services and pedagogical structures will respond to this demand, which may also originate from external pedagogical organizations.

Composition

Training Report and Teaching

Training Committee
Training courses conducted by IdiPAZ in 2011

Every year, the training committee conducts a survey to determine the needs of the members of the Institute, which allows the analysis of those areas of interest that require greater training and specialization on the part of researchers. It is important to note that the Training Committee encourages the participation of IdiPAZ personnel as coordinators of their courses, always under the auspices of the Committee itself and the continuing education department at HULP.

IdiPAZ Thesis

Therefore, one of the unit's main efforts is that our researchers and health professionals perceive the Innovation Node as a resource at their disposal, in the service of innovative ideas, protect their inventions and support the subsequent industrial development of patents, marks, utility models, performance protocols, computer applications, etc. The mission of the Innovation Node is not only to convey the rich scientific heritage of La Paz University Hospital in our socio-economic environment, but also to draw attention to the institute's organizational and operational structure.

OBJETIVES

The FIBHULP Innovation Node, created in June 2010 as one of the networks approved by the Carlos III Health Institute, was established with the firm intention of implementing a culture to protect innovative ideas created by and resulting from the research activity carried out in IdiPAZ. This structure includes the various research areas and groups through which the institute carries out its research activity, the support platforms it provides (and within which the node is located), research projects and clinical trials carried out by its researchers and the scientific publications.

ORGANISATION

The node also aims to exploit the considerable innovative potential created within our hospital as a precursor to the transfer of this potential to society. An example of what the Node will contribute to, to some extent, is the recently created IdiPAZ website:.

PORTFOLIO OF SERVICES

Innovation and

Transfer Activities

Innovation and Transfer Activities

Negotiation, preparation, review and/or correction of contracts on joint ownership of an invention owner's industrial property with other institutions and/or research centers. Negotiation, preparation, review and/or correction of agreements entered into with other companies, universities, public research centers and spin-offs.

ACTIVITIES

Negotiating, drafting, reviewing and/or correcting confidentiality agreements with researchers, external staff and interested third parties.

CONTACT Javier de Castro Carpeño

mail: [email protected] Tel: (34) 912 071 234
mail: mj_varela.innovació[email protected] Tel: (34) 912 071 234
mail : [email protected] Tel: (34) 912 071 234

Patents
Trademarks
Quality Assurance Activities
Clinical Trials

Huella digital genómica para predecir la respuesta clínica a la terapia antitumoral neoadyuvante en el cáncer colorrectal. Evaluación clínica del pie diabético Evaluación revisada de la membrana peritoneal Evaluación revisada del hipotálamo-hipófisis en.

HEALTHCARE S.L

HOFFMANN-LA ROCHE LTD

Ensayo multicéntrico, doble ciego, aleatorizado, de grupos paralelos, controlado con placebo para evaluar la eficacia y la seguridad de mastinib en pacientes con enfermedad de Alzheimer de leve a moderada. Emilio Estudio aleatorizado, doble ciego, controlado por palcebo para evaluar la eficacia y seguridad de NKTR-118 en pacientes con dolor no oncológico y estreñimiento inducido por opioides OIC.

HOFFMAN - LA ROCHE LTD

Platforms

BIOBANK

El estudio Celia multicéntrico, aleatorizado, doble ciego, controlado con placebo sobre la eficacia de natalizumab en la reducción de la progresión de la discapacidad en pacientes con esclerosis múltiple progresiva secundaria. Rafael Del Un ensayo comparativo multicéntrico, aleatorizado, doble ciego, controlado con placebo, de grupos paralelos para evaluar la eficacia de BF 2649 en el tratamiento de la somnolencia diurna excesiva en la narcolepsia.

COMPOSITION

FACILITIES

EQUIPMENT

1 ECG

UCICEC

PORTFOLIO OF SERVICES

Experimental Surgery Section

Cell culture technology has become one of the most important methods of scientific research in recent decades. To facilitate research groups' access to this technology, the Department of Cell Culture has been established as a central research support unit integrated into the Instituto de Investigación Sanitaria Hospital Universitario La Paz (IdiPAZ, Hospital La Paz Institute for Health Research).

Cell Cultures
Automatic Sequencing Laboratory

The Sequencing Laboratory of the IdiPAZ Health Research Institute of La Paz University Hospital was established with a commitment to support the many research groups associated with the institute. Based on this objective, the Sequencing Laboratory of IdiPAZ supports the lines of research of the various groups in the institute.

PORTFOLIO OF SERVICES

These facilities have enabled us to meet user demand and adjust the response time to meet user needs.

SUMMARY OF ACTIVITY 2011

OBJECTIVES

Immunohistochemestry and Image Analysis Laboratory
Continue and improve the services offered: expansion of the portfolio of techniques, implementation of the
Supervision and training of personnel recently in- corporated to the Institute in the best practices of
Training of technicians and researchers through parti- cipation in mentoring programmes for students of the
Facilitate the collaboration with groups outside Idi- PAZ as a result of the recognition of the quality and

Supervise and train newly incorporated Institute personnel in Institute corporate best practices in Immunohistochemistry and Image Analysis Laboratory best practices. Facilitation of collaboration with groups outside Idi-PAZ as a result of recognition of the quality and PAZ as a result of recognition of the quality and diversity of techniques offered in the Laboratory of Immunohistochemistry and Image Analysis.

EQUIPMENT / FACILITIES

Training of research personnel within the VEN Training Programme of the La Paz University Hospital

Continuation and improvement of the services provided: expansion of the portfolio of techniques, implementation of the portfolio of techniques, implementation of computerized protocols, scientific and technical consulting, management of cooperation with other departments of IdiPAZ for joint use of various devices, management of purchases and distribution control of common consumables for immunohistochemical techniques and laboratory waste management. Training of technicians and researchers through participation in mentorship programs for students of participation in mentorship programs for students of the Community of Madrid, Universidad Autónoma, Universidad Complutense and La Paz University Hospital.

Collaboration with groups outside IdiPAZ (Dr. Javier Codesal of the Department of Anatomy and Histolo-

Collaboration with groups belonging to IdiPAZ

HULP Radiological Protection Department personnel perform radiological protection and periodically monitor laboratory contamination levels. They are also responsible for the removal and management of waste products and the management of users' personal dosimeters.

EQUIPAMENT

Flow Cytometry Laboratory

Radioisotope Laboratory

Laboratory of Molecular Biology

Biostatistics Section

Scientific Production

RETICs and CIBERs

IIS10/00010

ADE09-90014

MAD-IIS-25-C

Institutional Projects

ADE08/90052

MAD-BIO-19-C

MAD-EECC-05-C

Clinical Practice

1.12 Q4 Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (SEMICYUC)/Sociedad Española de Nutrición Parenteral y Enteral (SENPE). 1,12 Q4 Sociedad Española de Nutrición Parenteral y Enteral (SENPE)/Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica (SEGHNP)/Asociación Nacional de Enfermería Intensiva Pediátrica y Neonatal (ANECIPN)/Sociedad Española de Cirugía Pediátrica (SECP).

Collaboration with international institutions

Neuroscience Area
Cardiovascular Area
Infectious Diseases and Immunity Area
Large Systems Pathology Area
Cancer and Human Molecular Genetics Area
Surgery, Transplantation and Health Technology Area
Composition
Summary
Research Lines
Research Activity

Università di Milano Università di Parma Università di Perugia Università di Pisa Università di Torino Università di Verona GIAPPONE. Università dell'Alabama Università della California Università di Cincinnati Università del Kansas Università del Massachusetts Università del Missouri Università del North Carolina.

Author: Pablo Orgaz Barnier

Universidad Autónoma de Madrid Blanca Amador Sastre Médico Área Especialista en Psicología Clínica Hospital Universitario La Paz Carmen Bayón Pérez Médico Área Especialista en Psiquiatría. Universidad Autónoma de Madrid Consuelo de Dios Perrino Doctora Especialista de Área en Psiquiatría Hospital Universitario La Paz María Teresa González Salvador Doctora Especialista de Área en Psiquiatría Hospital Universitario La Paz Nieves González Suárez Médico Especialista de Área en Psiquiatría La Paz Ana Hospital de Moreno Médico Especialista Psicología Hospital Universitario La Paz Ángela Palao Tarrero Médico Especialista de Área de Psiquiatría Hospital Universitario La Paz Pau Pérez Sales Médico Especialista de Área de Psiquiatría Hospital Universitario La Paz.

Research Line - Biological, psychological and so- cial factors in the development, evolution and

Group 1

The activity of the Psychiatry and Mental Health group focuses on the study of the biological, psychological and social factors in the development, evolution and treatment of mental disorders. Biological, psychological and social factors in the development, evolution and treatment of mental disorders.

Psychiatry and Mental Health

Psychiatric disorders, and mental health disorders in general, are among the most common disorders among the general population (11% to 19% in Spain) and are cross-sectionally involved in a large number of medical pathologies.

Authors: Palao, A.; Rodríguez Vega, B

Authors: Pérez-Sales, P

Principal Inv.: María Fe Bravo Ortiz Group: Psychiatry and Mental Health

Principal Inv.: María Teresa González Salvador Group: Psychiatry and Mental Health

Principal Inv.: Pau Pérez Sales Group: Psychiatry and Mental Health

Principal Inv.: Consuelo de Dios Perrino

Principal Inv.: Rosa Villanueva Peña

Group 2

Neurology and

Cerebrovascular Diseases

Name Position Institution Marta María Martínez

The first line is aimed at the pathophysiology and development of diagnostic tests and new therapies for neurological diseases in general. The second is focused on translational studies of cerebrovascular diseases, increasing knowledge of pathophysiology and therapeutic development aimed primarily at protecting and restoring the brain, with a special emphasis on the development of cell therapy.

Research Line - Cerebrovacular diseases

Sociocultural study on the self-perception of stroke and an analysis of doctor-patient communication. Risk factors for cerebral venous thrombosis influence the development of an associated venous infarction.

Research Line - Developmental disorders and neurological maturation (TRADESMA)

A cluster of four membrane-spanning domains subfamily A (MS4A) genes harbors a common variant associated with Alzheimer's disease. The MTHFD1L gene marker rs11754661 is not associated with Alzheimer's disease in a Spanish Po- sample.

Research Line – Neuromuscular diseases and spinocerebellar ataxias. Motor neuron diseases

Review of the news presented at the 26th Congress of the European Committee for Treatment. Review of the news presented at the 26th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (II).

Amyotrophic lateral sclerosis

Macular structure on optical coherence tomography after lamellar macular hole surgery and its correlation with visual outcome.

Díez-Tejedor, E

Authors: Oreja-Guevara, C

Authors: Arcas, J

Authors: Martínez Bermejo, A.; Alarcón, H

Authors: Martínez Bermejo, A

Aire Salguero, L.; Cerdán, S

Fuentes Gimeno, B

Authors: Moraleda Pérez, S.; Martínez Moreno, M

Authors: Fernández Guinea, S

Authors: Arpa, J.; Cruz Martínez, A

Principal Inv.: Exuperio Díez Tejedor Group: Neurology and Cerebrovascular Diseases

Principal Inv.: Blanca Fuentes Gimeno Group: Neurology and Cerebrovascular Diseases

Research line: Cerebrovascular Diseases Start year - Final year Management Center: FIBHULP Principal Inv.: Exuperio Díez Tejedor. Research direction: Cerebrovascular diseases Initial year - Final year Management center: FIBHULP Main inv.: Exuperio Díez Tejedor.

Principal Inv.: Exuperio Díez Tejedor; Celia Oreja Guevara

Principal Inv.: Francisco Javier Rodríguez de Rivera Garrido

Principal Inv.: Francisco Javier Arpa Gutiérrez Group: Neurology and Cerebrovascular Diseases

Principal Inv.: Samuel Ignacio Pascual Pascual Group: Neurology and Cerebrovascular Diseases

Principal Inv.: Ana Cristina Guadaño Ferraz Group: Neurology and Cerebrovascular Diseases

Principal Inv.: Exuperio Díez Tejedor Group: Neurology and Cerebrovascular Disorders Group: Neurology and Cerebrovascular Disorders Center: Hospital Universitario La Paz. Principal Inv.: Francisco Javier Arpa GutiérrezGroup: Neurology and Cerebrovascular Diseases Group: Neurology and Cerebrovascular Diseases.

Principal Inv.: Vicente Ibañez Mora Group: Neurology and Cerebrovascular Diseases

Principal Inv.: Jesús María López Arrieta Group: Neurology and Cerebrovascular Diseases

Principal Inv.: Francisco Vivancos Matellano Group: Neurology and Cerebrovascular Diseases

Principal Inv.: Ana Frank García

Título: Ensayo de extensión de fase 3 multicéntrico de seguridad y tolerabilidad a largo plazo de Bapineuzumab (AAB-001) en sujetos con enfermedad de Alzheimer que son portadores de apolipoproteína e4 y han participado en el estudio 3133K1-3000 -WW. Título: Estudio internacional, multicéntrico, transversal del rendimiento diagnóstico de los kits Abtest40 y Abtest42 para la determinación de los niveles en sangre de Aβ40 y Aβ42 y un estudio longitudinal de 24 meses de los cambios en sangre de Aβ40 y Aβ42 y su valor para predecir la progresión de la función cognitiva deterioro del desarrollo y/o desarrollo de demencia debido a la EA en pacientes con probable deterioro cognitivo leve amnésico (DCL-A).

Principal Inv.: Vicente Iváñez Mora

Principal Inv.: Jesús María López Arrieta

Principal Inv.: Antonio Martínez Bermejo

Principal Inv.: Mercedes Martínez Moreno Susana Moraleda Pérez

Principal Inv.: Celia Oreja Guevara

Título: Estudio de extensión multicéntrico, ciego a la dosis, para determinar la seguridad y eficacia a largo plazo de una dosis única de BG00012 en pacientes con esclerosis múltiple recurrente-remitente. Título: Estudio multicéntrico, aleatorizado, doble ciego, controlado con placebo sobre la seguridad y eficacia de dexpramipexol en sujetos con esclerosis lateral amiotrófica.

Principal Inv.: Francisco Vivancos Matellano

Título: Estudio multicéntrico, doble ciego, aleatorizado, de grupos paralelos, monoterapia, con control activo para determinar la eficacia y la seguridad de daclizumab de alto rendimiento frente a avonex en pacientes con esclerosis múltiple remitente-recurrente. inversión Director: Samuel Ignacio Pascual PascualTítulo: Fase III, aleatorizado, doble ciego Título: Ensayo clínico de fase III, aleatorizado, doble ciego, controlado con placebo para evaluar la eficacia y seguridad de GSK2402968 en sujetos con distrofia muscular de Duchenne n. carpeta: 3345.

Principal Inv.: Rafael del Río Villegas

Authors: Montserrat Bernabeu Guuitart, Jose Mª Climent Barberá, Jesús Figueroa Rodríguez, Luis

Juan García, Ester Marco Navarro, Susana Moraleda Pérez, Agustín Torrequebrada Giménez

Pozueta Larios, J

Cerdán García-Esteller, S

Facultad de Medicina Universidad Autónoma de Madrid David Fernández de Sevilla García Investigador Universidad Autónoma de Madrid Miguel Garzón García Catedrático. Facultad de Medicina Universidad Autónoma de Madrid José Julio Rodríguez Arellano Técnico de Laboratorio Universidad Autónoma de Madrid.

Research Line - Hodological, ultrastructural, elec- trophysiological and neurochemical bases of ponti-

Group 3

Facultad de Medicina Universidad Autónoma de Madrid Cristina Bódalo Tejedor Investigadora Predoctoral Universidad Autónoma de Madrid Marta Callejo Móstoles Ayudante de Laboratorio Universidad Autónoma de Madrid Esther del Cid Pellitero Investigadora Predoctoral Universidad Autónoma de Madrid Gemma de la Fuente Calvo Ayudante de Laboratorio Universidad Autónoma de Madrid Carmen de la Roza Ruíz Profesor. Una aproximación multidisciplinar a los mecanismos neurobiológicos implicados en la generación del estado de vigilia y sueño y los implicados en el procesamiento sensorial.

Neurobiological Basis of Sleep and Sensory Processing

Principal Inv.: Miguel Garzón García

To accomplish these two objectives, we are studying the role of the neurotrophin-activated PI3K/Akt/GSK-3b pathway and its role in antioxidant defense. Using genetically modified rodent models as well as pharmacological approaches, we are studying the contribution of this transcription factor to the protection against oxidative damage and neuroinflammation induced by MPTP and the Parkinson's toxin 6-OHDA.

Research Line - Role of oxidative stress in neuronal death and neuroinflammation in neurodegenerati-

An important finding of this group was the observation that this survival pathway regulates the transcription factor Nrf2, guardian of cellular redox homeostasis.

Research Line - The transcription factor Nrf2 as a new therapeutic target in Parkinson’s disease

Principal Inv.: Antonio Cuadrado Pastor

Group 4

Neuroprotective Strategies in Neurodegenerative Diseases

Beatriz Álvarez Castelao Investigador Predoctoral Universidad Autónoma de Madrid Fernando Losada Urzaiz Investigador Predoctoral Universidad Autónoma de Madrid Sergio Martín González Investigador Postdoctoral Universidad Autónoma de Madrid Tania Ramos Moreno Investigadora Postdoctoral Universidad Autónoma de Madrid. Estudiar las bases cuantitativas para comprender los mecanismos de regulación del recambio de proteínas propensas a la agregación.

Research line – Study of the quantitative basis for understanding the mechanisms of protein turnover

Recently, but not exclusively, we have worked on protein turnover and transcription factors involved in Parkinson's disease as a reference cellular stress disease caused by defective proteostasis involving chaperones and protein degradation pathways. This research may shed light on the possible therapeutic targets in these types of conformational diseases due to cellular proteostasis disorders, which include neurodegenerative diseases.

Principal Inv.: José González Castaño

Group 5

Cellular Proteostasis and Conformational Diseases

Facultad de Medicina Universidad Autónoma de Madrid Begoña Rodríguez Menéndez Técnico de Laboratorio Universidad Autónoma de Madrid Pablo Rubio Garrido Profesor Asociado. Facultad de Medicina Universidad San Pablo-CEU Rosa Sánchez Lozano Técnico de Laboratorio Universidad Autónoma de Madrid.

Research Line - Structure of neural systems and models of human neurological diseases

Facultad de Medicina Universidad Autónoma de Madrid Juan Álvarez-Linera Prado Especialista en Radiodiagnóstico Universidad Autónoma de Madrid Carlos Avendaño Trueba Catedrático. Facultad de Medicina Universidad Autónoma de Madrid Marina Cabrizo Alonso Técnico de Laboratorio Universidad Autónoma de Madrid Guadalupe Camarero Calderón Investigador Postdoctoral IIB Alberto Sols.

Parkinson’s and Alzheimer’s) in the brains of primates and rodents

Group 6

Especialista en anatomía patológica Universidad Autónoma de Madrid María García-Amado Sancho Investigadora predoctoral Universidad Autónoma de Madrid María José García-Miguel Piedras Ayudante de cátedra. Facultad de Medicina Universidad Autónoma de Madrid Agnieszka Krzyanowska Investigadora Predoctoral Universidad Autónoma de Madrid Raquel Márquez López Ayudante de Laboratorio Universidad Autónoma de Madrid Yasmina Martín Martínez Investigadora Predoctoral Universidad Autónoma de Madrid Marta Miró Murillo Ayudante de Laboratorio Universidad Autónoma de Madrid César Porrero Calzado Investigador Predoctoral Universidad Autónoma de Madrid Lucía Sepúlveda Profesora de Prensa.

Structure, Neurochemistry and Plasticity of Neural Circuits of the

Our project aims to identify and quantify the cellular microcircuitry, neurochemistry and plasticity of neural networks connecting the cerebral cortex and the thalamus, as well as a number of systems afferent to the thalamus and its modification by stimulation or injury . Structure of neural systems and models of human neurological diseases (Parkinson's and Alzheimer's) in the brain of primates and rodents.

Cerebral Cortex and Thalamus

Although our goal is to advance understanding of the human brain, the implementation of the experimental techniques with the greatest problem-solving capacity must be performed largely in animal, primate, and rodent models.

Research Line - Inhibitory mechanisms involved in neuropathic pain in animal models

Principal Inv.: Carlos Avendaño Trueba

Facultad de Medicina Universidad Autónoma de Madrid Jaime Renart Pita Investigador Científico IIB Alberto Sols. Facultad de Medicina Universidad Autónoma de Madrid Gema Atienza Toledo Técnico de Laboratorio Universidad Autónoma de Madrid José Luis Cedillo Mireles Investigador Predoctoral Universidad Autónoma de Madrid Ana María de Lucas Cerrillo Investigador Predoctoral Universidad Autónoma de Madrid Verónica Lagos Lagos Investigadora Predoctoral Universidad Autónoma de Madrid Constanza Maldifasi Gatica CONICYT Investigador Predoctoral, Gobierno de Chile.

Group 7

It is well known that cell-free plasma DNA released after cell death can trigger a systemic inflammatory response in patients with autoimmune diseases such as systemic lupus erythematosus and can even predict mortality in critically ill patients. For example, neurons in the central nervous system (CNS) can synthesize and express tumor necrosis factor (TNF) and interleukin-1, and these cytokines can participate in neuronal communication.

Neurobiology of the Inflammatory Response

Another interesting line of research is the molecular characterization of several signaling pathways in different dysplastic cell lines in experimental neoplasia. Identification and characterization of different signaling pathways in experimental cellular models of dysplasia and neoplasia.

Research Line - Molecular mechanisms involved in the innate immune response

Research Line - Functional and pharmacological characterisation of various subtypes of neuronal

Principal Inv.: Francisco Arnalich Fernández Group: Neurobiology of the inflammatory response

Principal Inv.: Carmen Montiel López Group: Neurobiology of the inflammatory response

Principal Inv.: Francisco Arnalich Fernández Exuperio Díez Tejedor

Principal Inv.: Almudena Castro Conde Francisco Arnalich Fernández

DOCUMENTS IF CITATIONS

Group 30

Involvement of Glycinergic and Glutamatergic Systems in Central

Nervous System Pathologies

Molecular basis of the differential interaction with lithium of glycine transporters GLYT1 and GLYT2. Endocytosis of the Neuronal Glycine Transporter GLYT2: Role of Membrane Rafts and Protein Kinase C-Dependent Ubiquitination.

Pathophysiology of glutamatergic neurotransmis- sion

Unidad de Investigación de Arritmias/Electrofisiología Robótica Hospital Universitario La Paz José Raúl Moreno Gómez Jefe de Sección de Hemodinámica Hospital Universitario La Paz Mar Moreno Yangüela Jefe de Sección de Imagen Cardíaca Hospital Universitario La Paz Fernando Olías de la Cruz Médico Especialista de Área de Cardiología Hospital Universitía La Paz Oliver Ruiz Jefe Unidad de Cardiopatías Congénitas del Adulto Hospital Universitario La Paz Elena María Refoyo Salicio Médico Especialista de Área en Cardiología Hospital Universitario La Paz Juan Ramón Rey Blas Médico Especialista de Área en Cardiología Hospital Universitario La Paz José Ruiz Cantador Médico Especialista de Área en Cardiología Hospital Universitario La Paz Ángel Sánchez Recalde Médico Especialista de Área de Cardiología Hospital Universitario La Paz. El grupo está formado por varias unidades asistenciales del Servicio de Cardiología del Hospital La Paz: Clínica/Unidad de Crónicos, cardiología intervencionista, imagen cardiaca, electrofisiología, rehabilitación y cardiopatías congénitas del adulto.

Research Line - Myocardial ischaemia

Group 8

Hentschel Jefe de Servicio de Cardiología Hospital Universitario La Paz Eduardo Armada Romero Médico de Área Especialista en Cardiología Hospital Universitario La Paz Isabel Antorrena Miranda Médico de Área Especialista en Cardiología Hospital Universitario La Paz Luis Calvo Orbe Médico de Área Especialista en Cardiología Hospital Universitario La Paz Sergio Castrejon Castrejón Médico de Área Especialista en Cardiología Hospital Universitario La Paz Almudena Castro Conde Médico de Área Especialista en Cardiología Hospital Universitario La Paz Regina Dalmau Médico de Área Especialista en Cardiología Hospital Universitario La Paz Francisco Domínguez Melcón Médico de Área Especialista en Cardiología Hospital Universitario La Paz David Filgueiras Rama Médico de Área Especialista en Cardiología Hospital Universitario La Paz Jaime Fernández de Bobadilla Médico, Especialista en Cardiología Hospital Universitario La Paz Guillermo Galeote García, Médico, Especialista en Cardiología Hospital Universitario La Paz Ana González García, Médica, Especialista en Cardiología Universidad de La Paz Gabriela Guzmán Martínez, Médica, Especialista en Cardiología La Hospital Universitario de la Paz Santiago Jiménez Valero Médico, Especialista en Cardiología Hospital Universitario La Paz María Teresa López Fernández Médico, Especialista en Cardiología Hospital Universitario La Paz Esteban López de Sá Areses Jefe de Servicio de Cuidados Intensivos Cardiacos Hospital Universitario La Paz José Luis Merino Llorens Médico, especialista en la campo de la cardiología.

Research on Invasive Clinical Cardiology - ICCI-Paz

The SPIRIT V Study A Clinical Evaluation of the XIENCE V Everolimus-Eluting Coronary Stent System in the Treatment of Patients with De Novo Coronary Artery Lesions. Quantitative troponin and death, cardiogenic shock, cardiac arrest, and new heart failure in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS): insights from the Global Registry of Acute Coronary Events. López-Sendón J member of the Endpoint Validation Committee).

Hindricks, G

Evaluation of the Functional Status Questionnaire in Heart Failure: A Substudy of the Second Bisoprolol Heart Failure Survival Study (CIBIS-II). G.; Gómez-Bueno, M.; Ferrer, M.; Artigas, R.; Zapata, A.; Elosua, R.; (Guzman, G.) Validation of the Spanish Version of the Kansas City Cardiomyopathy Questionnaire.

Authors: Guzmán, G.; Gómez Rubin de Célix, M

Acute rheumatic fever in an adult with recovered tetralogy of Fallot: the role of acquired diseases in patients with congenital heart disease. Closure of ventricular septal defect after surgical septummyectomy by hybrid procedure in an adult patient.

C.; Refoyo, E

Principal Inv.: Esteban López de Sá Areses Group: Research on Invasive Clinical Cardiology - ICCI-Paz

Principal Inv.: José Luis Merino Llorens

Principal Inv.: Rafael Peinado Peinado

Principal Inv.: José Luis López-Sendón Hentschel Group: Research on Invasive Clinical Cardiology - ICCI-Paz

Principal Inv.: José Luis López-Sendon Hentschel Group: Research on Invasive Clinical Cardiology - ICCI-Paz

Principal Inv.: Santiago Jiménez Valero

Principal Inv.: Esteban López de Sá Areses

Principal Inv.: José Luis López-Sendón Hentschel Title: Estudio TITAN, de calidad de la anticoagulación oral en la

Principal Inv.: José Luis Merino Llorens Title: Estudio aleatorizado, doble ciego, con-

Título: Evaluación de los efectos antiarrítmicos de 3 dosis orales de S44121 versus placebo en pacientes con insuficiencia cardíaca crónica, disfunción sistólica del ventrículo izquierdo y riesgo de desarrollar arritmias ventriculares. Título: Estudio de fase II aleatorizado, doble ciego, doble ciego, controlado por palcebo, de rango de dosis que evalúa el efecto de la ranolazina en el mantenimiento del ritmo sinusal después de la cardioversión eléctrica en pacientes con fibrilación auricular no permanente.

Principal Inv.: José Raúl Moreno Gómez

Principal Inv.: Fernando Olías de la Cruz

Principal Inv.: Juan Ramón Rey Blas

Rafael Gabriel Sánchez Médico Especialista de Área Hospital Universitario La Paz Juan Carlos Abanades Herranz Subdirector Médico. Unidad de Diabetes Hospital Universitario La Paz Jesús Martínez de Dios Médico Especialista en Medicina Familiar y Comunitaria.

Research Line - Epidemiology and prevention of cardiovascular and metabolic diseases

Group 9

Víctor Aparicio Martín Investigador Predoctoral Área Única de Atención Primaria Rosa Ángeles Arnal Selfas Directora de Enfermería Área Única de Atención Primaria Natalia Hillman Gadea Especialista del Área Facultativa de Endocrinología y. Área Unificada de Atención Primaria Blanca Novella Arribas Medicina Familiar y Comunitaria Médico Especialista Agencia Laín Entralgo.

Clinical Epidemiology and

The group's portfolio includes services in epidemiological methods, study design, clinical study monitoring and statistical analysis. The group focuses on promoting new solutions to complex CV problems, creating new knowledge, transforming paradigms of CV health prevention, improving human CV health and generating wealth.

Cardiometabolic Disease Prevention

Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study. Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study.

Principal Inv.: Rafael Gabriel Sánchez

Group 10

Cardiovascular Epidemiology and Nutrition

Research Line - Epidemiology and prevention of obesity

Bedtime hypertension treatment response increases ambulatory blood pressure control and reduces cardiovascular risk in resistant hypertension. Clinical characteristics of 8295 patients with resistant hypertension classified on the basis of ambulatory blood pressure monitoring.

Research Line - Epidemiology and prognosis of chronic heart failure

The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis. Physician Perception of Blood Pressure Control and Treatment Behavior in High-Risk Hypertensive Patients: A Cross-Sectional Study.

Principal Inv.: Fernando Rodríguez Artalejo Group: Cardiovascular and Nutritional Epidemiology

Group 11

Metabolic-Vascular Unit

Research Line - Purine metabolism

Authors: Torres Jiménez, R.; García Puig, J

Principal Inv.: Juan García Puig Group: Metabolic-Vascular Unit

Principal Inv.: Pedro Luis Martínez Hernández Group: Metabolic-Vascular Unit

Principal Inv.: Juan García Puig

Group 13

Sex Hormones and Vascular Function

Research Line - Neuronal regulation of vascular tone

Authors: Ferrer, M

Principal Inv.: Mercedes Ferrer Group: Sex Hormones and Vascular Function

Group 14

Coagulopathies and Alterations of Haemostasis

Research Line - Haemophilia A and B

Research Line - Haemostasis disorders

Jiménez, V

Principal Inv.: Nora Viviana Butta Coll Group: Coagulopathies and Alterations of Haemostasis

Principal Inv. Nora Viviana Butta Coll Group: Coagulopathies and Alterations of Haemostasis

Principal Inv.: Elena García Arias-Salgado Group: Coagulopathies and Alterations of Haemostasis

Principal Inv.: María Teresa Álvarez Román Title: Estudio abierto no randomizado con escalada de do-

Principal Inv.: María Teresa Álvarez Román Title: Evaluacion abierta y multicentrica de la seguridad, la

Principal Inv.: María Teresa Álvarez Román Title: Estudio farmacocinético y de seguridad abierto, multi-

Principal Inv.: María Teresa Álvarez Román Title: Estudio de fase III, multicéntrico y abierto que investiga

Principal Inv.: Víctor Jiménez Yuste

Principal Inv.: Mónica Martín Salces

Group 15

Vascular Physiology and Pharmacology

Research Line - Oxidative stress, COX-derived products and vascular function and remodelling

Changes with hypertension and other cardiovascular pathologies

Research Line - Cardiovascular effects of heavy metals

Research Line - Adipose tissue and vascular alterations in cardiovascular pathologies

Principal Inv.: Mercedes Salaíces Sánchez Group: Vascular Physiology and Pharmacology

Infectious Diseases

Group 16

AIDS and Infectious Diseases

Research Line - Antiretroviral therapy & Resis- tance

Research Line - Liver Disease

Research Line - Optimisation of antibiotic therapy (ID no HIV)

Romero, M

Principal Inv.: Juan Julián González García Group: AIDS and Infectious Diseases

Title: East and Southern Africa Research Network for the Evaluation of Second-Line Therapy in HIV Infection.

Principal Inv.: José Ramón Arribas López Group: AIDS and Infectious Diseases

Principal Inv.: José Ignacio Bernardino de la Serna Group: AIDS and Infectious Diseases

Principal Inv.: Juan Julián González García Group: AIDS and Infectious Diseases

Principal Inv.: José Ramón Paño Pardo Group: AIDS and Infectious Diseases

Principal Inv.: Miriam Estébanez Muñoz Group: AIDS and Infectious Diseases

Principal Inv.: José Ramón Arribas López Juan González García

José María Peña Sánchez de Rivera Group: AIDS and Infectious Diseases

Principal Inv.: José Ramón Arribas López

Título: Estudio de fase III para demostrar la actividad antiviral y la seguridad de dolutegravir en sujetos adultos infectados por el VIH-1 que no han respondido a un régimen de tratamiento que contiene un inhibidor de la integrasa. Título: Estudio de fase 3, doble ciego, doble ciego, multicéntrico, aleatorizado de la seguridad y eficacia de Elvitegravir potenciado con ritonavir en comparación con Raltegravir, cada uno administrado como régimen de base en sujetos adultos infectados por el VIH. 1 que recibió tratamiento antirretroviral Expediente No.: Anexo-2 2711.

Principal Inv.: José Ignacio Bernardino de la Serna Title: Análisis epidemiológico transversal para describir las

Título: Estudio de fase III, aleatorizado, doble ciego de TMC278 25 mg una vez al día en comparación con efavirenz 600 mg una vez al día, en combinación con una terapia de base establecida que consiste en tenofovir disoproxil fumarato y emtricitabina en pacientes infectados por el VIH -1, sin tratamiento antirretroviral previo Archivo No. .: Anexo-1 2559. Título: Estudio de fase III, aleatorizado, doble ciego para evaluar la eficacia y seguridad de GSK1349572 50 mg una vez al día frente a raltegravir 400 mg dos veces al día, ambos administrados.

Principal Inv.: José Ignacio Bernardino de La Serna Title: Estudio multicéntrico, observacional, transversal, para

Título: Estudio abierto, aleatorizado y de fase 3B para evaluar la seguridad y la eficacia de un régimen de un solo comprimido de emtricitabina/rilpivirina/tenofovir disoproxil fumarato en comparación con un régimen de un solo comprimido de efavirenz/emtricitabina. Título: Estudio de fase IIB aleatorizado, controlado y parcialmente ciego para investigar la seguridad, la eficacia y la relación dosis-respuesta de bms-663068 en el tratamiento de sujetos infectados por el VIH-1 con tratamiento previo, seguido de un período de tratamiento.

Principal Inv.: María Isabel de José Gómez Title: Calidad de vida, Función neurocognitiva y característi-

Título: Ensayo clínico aleatorizado, abierto, de no inferioridad con un seguimiento de 96 semanas de la eficacia de atazanavir/ritonavir + lamivudina como terapia de mantenimiento en pacientes con carga viral reducida. Título: Un estudio de selección de dosis diaria de fase Iib de GSK1349572 en combinación con abacavir/.

Principal Inv.: María Isabel de José Gómez Title: KONCERT: estudio sobre la farmacocinética, la seguri-

Título: Estudio para evaluar la actividad y tolerabilidad de la terapia combinada con Lopinavir/ritonavir y 3TC en reemplazo de una terapia triple que incluye Lopinavir/rRtonavir y 3TC o FTC en pacientes con infección por VIH y supresión virológica: un ensayo clínico controlado abierto, abierto por asignación aleatoria, con una duración de 48 semanas.

Principal Inv.: María Isabel de José Gómez Title: Calidad de vida, función neurocognitiva y característi-

Principal Inv.: Juan González García

Título: Estudio abierto de fase III para evaluar la seguridad, tolerabilidad y eficacia de T MC435 en terapia triple con Peginterferón-2A y Ribavirina en pacientes con infección crónica por el genotipo 1 del virus de la Hepatitis C VHC coinfectados con VIH tipo 1 (VIH- 1) está infectado. . Título: Estudio de fase III aleatorizado, doble ciego para evaluar la seguridad y eficacia de GSK1349572 50 mg una vez al día frente a raltegravir 400 mg dos veces al día, ambos administrados en combinación con una terapia de base seleccionada por el investigador: tigador durante 48 semanas en sujetos adultos que están infectados por el VIH-1, que hayan recibido previamente tratamiento antirretroviral, a excepción de un inhibidor de la integrasa.

Principal Inv.: María Luisa Montes Ramírez

Título: Prevalencia y factores asociados a la esteatosis hepática en la población de pacientes infectados por el VIH en España Comparación entre sexos. Título: Estudio de costo-efectividad de las estrategias terapéuticas actuales para simplificar el tratamiento antirretroviral de gran actividad (TARGA) contra el virus de la inmunodeficiencia humana (VIH) No. Expediente: PI-1178.

Principal Inv.: José Ramón Paño Pardo

Título: Estudio observacional, retrospectivo, multicéntrico para determinar el perfil de seguridad y eficacia de las diferentes combinaciones de targa en pacientes de 50 años o más (cohorte española TRIP). Título: Calidad de vida, función neurocognitiva y características clínicas de mujeres adultas VIH+ en España.

Principal Inv.: Juan José Ríos Blanco

Ángel Julián Robles Marhuenda Title: Prevalencia y manejo clínico de pacientes hospitalizados

Principal Inv.: Paloma Jara Vega José Ramón Paño Pardo

Group 18

Molecular Microbiology

Research Line - Molecular epidemiology

Research Line - Molecular methods for diagnostics of infectious diseases

Research Line - Biochemistry and molecular biology of bacterial cell division

Research Line - Clinical Microbiology

Principal Inv.: Jesús Mingorance Cruz Group: Molecular Microbiology

Principal Inv.: Silvia García Bujalance Group: Molecular Microbiology

Principal Inv.: Julio García Rodríguez Group: Molecular Microbiology

Principal Inv.: María Pilar Romero Gómez Group: Molecular Microbiology

Group 19

Immuno-Rheumatology

Influence of immunogenicity on the efficacy of long-term infliximab treatment in rheumatoid arthritis. Association of the acid phosphatase locus 1*C allele with risk of cardiovascular events in patients with rheumatoid arthritis.

Principal Inv.: María Eugenia Miranda Carús

Lack of association of NAMPT rs9770242 and rs59744560 polymorphisms with disease susceptibility and cardiovascular risk in patients with rheumatoid arthritis. Lack of association between IL6R rs2228145 and IL6ST/gp130 rs2228044 gene polymorphisms with cardiovascular disease in patients with rheumatoid arthritis.

Principal Inv.: María Eugenia Miranda Carús Group: Immuno-Rheumatology

Principal Inv.: Alejandro Balsa Criado Group: Immuno-Rheumatology

Principal Inv.: Dora Pascual Salcedo Group: Immuno-Rheumatology

Principal Inv.: Eugenio de Miguel Mendieta Title: Prevalencia de espondiloartritis axial y periférica en

Principal Inv.: Eugenio de Miguel Mendieta Title: Validez de distintas medidas en la evaluación de la ac-

Principal Inv.: Emilio Martín Mola

Título: Estudio abierto, multicéntrico y de fase 3B para evaluar la seguridad y eficacia a largo plazo de LY2127399 en pacientes con artritis reumatoide (AR). Título: Ensayo aleatorizado, doble ciego, controlado con placebo, de grupos paralelos para evaluar la eficacia y la seguridad de Sbi-087 en sujetos seropositivos con artritis reumatoide activa en tratamiento estable con metotrext.

Principal Inv.: Antonio Torrijos Eslava

Título: Estudio de fase 3, multicéntrico, aleatorizado, doble ciego, controlado con placebo que evalúa la eficacia y la seguridad de LY2127399 en pacientes con artritis reumatoide (AR) de moderada a grave que no han respondido adecuadamente a uno o más TNF-ALFA diferentes inhibidores Título: Ensayo clínico de no inferioridad para evaluar la eficacia y seguridad de la combinación de condroitín sulfato y clorhidrato de glucosamina frente a celecoxib en pacientes con artrosis de rodilla.

Polo

Título: Ensayo clínico aleatorizado, doble ciego, multicéntrico para evaluar la seguridad y eficacia de la combinación de tocilizumab y metotrexato frente al cambio a tcz en pacientes con artritis reumatoide activa que han tenido una respuesta inadecuada al tratamiento previo con MTX y baja actividad de la enfermedad se logró con la combinación de TCZ y MTX. Título: Estudio aleatorizado, doble ciego, controlado con placebo para evaluar la eficacia y seguridad de NKTR-118 en pacientes con dolor no oncológico y estreñimiento causado por opioides OIC.

Principal Inv.: Antonio Torrijos Eslava Teresa Gallardo Domenech

Principal Inv.: Antonio Torrijos Eslava Javier González Polo

Group 20

Innate Immune Response

Research Line – Molecular mechanisms of endotoxin tolerance in several clinical contexts: respira-

Research Line – Role of TREM-1 as a marker of lung diseases

A human multi-epitope recombinant vaccinia virus as a universal T-cell vaccine candidate against influenza virus. The host range restriction of the Vaccinia Virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein.

Research Line – Role of IRAK-M pseudokinase and TREM-1 receptor in endotoxin tolerance in

Cooperation between adenosine and macrophage Toll-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of the PFKFB3 gene.

Principal Inv.: Eduardo López Collazo Group: Innate Immune Response

Principal Inv.: Lisardo Boscá Gomar Group: Innate Immune Response

Principal Inv.: Susana Guerra García Group: Innate Immune Response

Component defects that are isolated, associated with infectious processes or autoimmune; 2) disorders in re-

First, the group seeks to understand the molecular mechanisms of diseases related to the complement system, the majority of which are rare diseases.

Research Line – Biochemical and functional studies of Complement regulatory proteins in renal patho-

Group 21

Diagnosis and Treatment of Diseases Associated with

Abnormalities of the Complement System

Research Line – Diagnosis, molecular studies and screening for disease-modifying genes in Hereditary

Principal Inv.: Margarita López Trascasa

Principal Inv.: Pilar Sánchez-Corral Gómez

Principal Inv.: Antonia Peña Carrión

Principal Inv.: Marta Melgosa Hijosa

Principal Inv.: Marta Melgosa Hijosa Carlos Jiménez Martín

Name: Complementest Registration No.: 009658791

Group 22

Lymphocyte Pathophysiology in Immunodeficiencies

Research Line – Bases for lymphoid function de- ficiency in immunodeficiencies

Research Line – Role of TLRs and signalling pathways

Authors: López-Granados, E

Authors: del Castillo Martín, F.; Méndez Echevarría, A

Authors: Méndez Echevarría, A

Principal Inv. : Eduardo López Granados

Principal Inv.: Ángel Robles Marhuenda

Authors: Méndez Echevarría A

Large System Pathology

Area

3.4.4.: Group 26 Neonatology

Group 23

Respiratory Diseases

Research Line – Cardiovascular morbidity of sleep-disordered breathing

Romera Cano, D

Authors: García Río, F

Authors: Villasante Fernández-Montes, C

Authors: García Río, F.; Gómez Mendieta, M.A

Principal Inv.: Francisco García Río Group: Respiratory Diseases

Principal Inv.: Francisco García Río

Principal Inv.: Juan José Cabanillas Martín Carlos Villasante Fernández-

The fundamental objective of our group is to deepen the understanding of the molecular machinery of the hypoxia response. Implication for the variability of the clinical course of patients suffering from hypoxic gait pathology.

Laura Gómez Maldonado Researcher Predoctoral Universidad Autónoma de Madrid Olga Roche Losada Researcher Postdoctoral IIB Alberto Sols. In addition to providing a general view of the response to hypoxia, this line of research may help identify genes that are useful markers for the diagnosis and monitoring of diseases that progress with the development of tissue hypoxia, such as neoplasms and respiratory and cardiovascular diseases.

Principal Inv.: Luis del Peso Ovalle

Group 24

Specifically, we aim to identify, using a combination of bioinformatic and molecular biology techniques, the complement of genes induced by hypoxia through HIF and to characterize their function in the response to hypoxia. Identification of genes regulated by HIF and their involvement in adaptation to hypoxia and potential in diagnosis.

Regulation of Gene Expression and by Hypoxia

Group 25

Nephrology

A mouse model for peritoneal dialysis: investigating the effects of dialysis fluids, pharmacological interventions and genetic manipulation (KO, transgenic). Ultrasound contrast analysis of the renal microvasculature in renal transplantation - Involvement of CMV in the renal graft.

Research Line – Adult Renal Polycystosis. Family Studies and treatment proposals

Research Line – Incorporation of a psychologist into the department of nephrology: criteria and

Research Line – Establishment of normal perito- neal functional in humans

Low-GDP peritoneal dialysis fluid ('balance') has less in vitro and ex vivo influence on epithelial-to-mesenchymal transition (EMT) of mesothelial cells than a standard fluid. Outcome and prognostic factors in HIV-1-infected patients on dialysis in the cART era: a GESIDA/SEN cohort study.

Principal Inv.: Rafael Selgas Gutiérrez Group: Nephrology

Title: Evaluation of a psychoeducational program to promote compliance in patients with end stage renal disease.

Principal Inv.: María Elena González García Group: Nephrology

Principal Inv.: Carlos Jiménez Martín Marta Melgosa Hijosa

Principal Inv.: Fernando Escuín Sancho

Principal Inv.: Carlos Jiménez Martín

Principal Inv.: Maria Ovidia López Oliva

Principal Inv.: Teresa Olea Tejero

Principal Inv.: Rafael Sánchez Villanueva

Principal Inv.: Rafael Selgas Gutiérrez

Principal Inv.: Maximino Alberto Torre Carballada

Group 26

Neonatology

Título: Estado de la tiroides y hemodinámica en recién nacidos de muy bajo peso al nacer: evaluación sistemática de la influencia de la función tiroidea y la suplementación hormonal temprana en la circulación sistémica y cerebral. Título: Evaluación del tratamiento farmacológico convencional para el cierre del conducto arterioso permeable en recién nacidos prematuros: impacto de nuevas líneas terapéuticas.

Research Line – Neonatal pulmonary and cardiovas- cular pathology

Bardhë, D.; García-Alix, A.; Valverde, E.; Tenorio, V.; Vento, M.; Cabaña, F.; Comisión de Normas de la Sociedad Española de Neonatología (SEN).

Authors: Cabañas, F.; Pellicer, A

Authors: Cabañas, F.; Valverde, E

Authors: Pellicer, A.; López-Ortego P

Principal Inv.: Eva Valverde Núñez Group: Neonatology

Principal Inv.: Fernando Cabañas González

Principal Inv.: Fernando Cabañas González Group: Neonatology

Principal Inv.: Adelina Pellicer Martínez Group: Neonatology

Principal Inv.: Félix Omeñaca Terés

Principal Inv.: Miguel Sáenz de Pipaón Marcos Title: Estudio de fase 3 prospectivo, aleatorizado, doble ciego

Principal Inv.: Sofía Salas Hernández

Group 27

Aging and Fragility in the Elderly

Research Line – Intervention strategies for the prevention and functional reintegration of frail

Hospitalizations for sensitive conditions for ambulatory care and quality of primary care their relationship with socioeconomic and health care variables in the Madrid Regional Health Service (Spain). Activities of daily living after hip fracture: profile and rate of recovery during 2 years of follow-up.

Principal Inv.: Ángel Otero Puime Group: Aging and Fragility in the Elderly

An assessment of its impact on the clinical course of patients with hip fracture and an assessment of the financial impact.

Principal Inv.: Juan Ignacio González Montalvo Group: Aging and Fragility in the Elderly

Group 28

Molecular Hepatology

Research Line – Molecular basis of paediatric liver diseases

Principal Inv.: Luis Álvarez García Group: Molecular Hepatology

Principal Inv.: María de los Ángeles Pajares Tarancón

Authors: Martínez-Fernández P, Martínez-Glez V, Álvarez L

Group 44

Diagnosis and Treatment of Allergic Diseases

Research line - Food allergy (milk, egg, fruit, grain): Molecular diagnosis (for allergenic components): Molecular diagnosis (for allergenic components) and treatment with oral desensitization.

Research Line - Epidemiology, physiopathology, diagnosis and treatment of angioedema and urticaria

Research Line – Studies on bronchial hyperrespon- siveness to direct and indirect agents and airway in-

Research Line - Eosinophilic diseases of the respi- ratory tract (eosinophilic bronchitis) and digestive

Comparison of Budesonide/Formoterol maintenance and sedation therapy versus conventional best practice in asthma management in Spain. Prevalence of Severe Uncontrolled Persistent Asthma in Hospital Pneumology and Allergy Units in Spain.

Research Line - Aspirin-exacerbated respiratory disease (AERD): Inflammatory markers and des-

Prevalence and characteristics of rhinitis in adult asthmatic patients attending allergist, primary care and pulmonologist facilities in Spain (AIR study). Overall asthma control is achieved with budesonide/formoterol maintenance and sedation therapy for patients at various stages of treatment.

Research Line - Adverse immunologic reactions

Hexamethylene diisocyanate-induced asthma is associated with genetic polymorphisms of CD14, IL-13, and IL-4 receptor alpha.

Principal Inv.: María Teresa Caballero Molina Group: Diagnosis and Treatment of Allergic Diseases

Principal Inv.: Pilar Barranco Sanz

Principal Inv.: María Pilar Encarnación Barranco Sanz Title: Estudio transversal epidemiológico y descriptivo sobre

Principal Inv.: Irina Diana Bobolea

Principal Inv.: María Teresa Caballero Molina Title: La carga humanística y económica del angioedema

Principal Inv.: Santiago Eugenio Quirce Gancedo

Group 47

Ophthalmology

Research Line - Intravitreal therapy

Principal Inv.: Félix Armadá Maresca Group: Ophthalmology

Principal Inv.: David Antolín García

Principal Inv.: Félix Armadá Maresca

Principal Inv.: Cosme Lavín Dapena

Group 48

Gynecology and Obstetrics

We focus on several aspects related to clinical and experimental research on the female genital tract and pregnancy and childbirth. Our goal is to create a research group dedicated to all aspects related to gynecology and obstetrics.

Author: Silvina Kazlauskas

Research Line - Evaluation and treatment of on- cologic diseases in gynecology

Research Line - Molecular disorders in preeclam- sia and other obstetrical diseases

Periovulatory follicular volume and vascularization determined by 3D and Power Doppler ultrasonography as pregnancy predictors in intrauterine insemination cycles.

Authors: Zapardiel I

Principal Inv.: Ignacio Zapardiel Group: Gynecology and Obstetrics

Principal Inv.: Ramón Usandizaga Elio

Group 49

Emergency

Título del capítulo: Disnea súbita = tromboembolismo pulmonar Título del libro: Jornada sobre casos clínicos de infecciones en urgencias Editorial: Edicomlet, S.L.: ISBN. Título del capítulo: Varón de 47 años con infección por el VIH consulta por fiebre de las agujas durante dos días tras volver del Trópico Título del libro: Jornada sobre casos clínicos de infecciones en urgencias Editor: Edicomlet, S.L.: ISBN.

Authors: Quintana Díaz, M