Opinions and beliefs of the Spanish population about serious mental illnesses (schizophrenia and bipolar disorder). Low sensitivity of echocardiography compared with contrast-enhanced transcranial Doppler in the right left shunt.
Bases Neurológicas del Sueño y del Procesamiento Sensorial
Publicaciones
Estrategias Neuroprotectoras en Enfermedades Neurodegenerativas
Signaling pathways activated by the phytochemical nordihydroguaiaretinoic acid contribute to a Keap1-independent regulation of Nrf2 stability: role of glycogen synthase kinase-3. Structural and functional characterization of Nrf2 degradation of the glycogen synthase kinase 3/beta-TrCP axis.
Proteostasis celular y enfermedades conformacionales
Estructura, Neuroquímica y Plasticidad de los Circuitos Neuronales de la Corteza Cerebral
Neuroinmunología Básica y Aplicada
Grupo 8 – Investigación en Cardiología Clínica e Invasiva - ICCI-PAZ
Efficacy of apixaban compared to warfarin on renal function in patients with atrial fibrillation: insights from the ARISTOTLE study. A therapeutic option in patients with atrial fibrillation and esophageal varices and a high risk of bleeding.
Epidemiología Clínica y Prevención de Enfermedades Cardiometabólicas
Insulin secretion and its determinants in the progression from impaired glucose tolerance to type 2 diabetes in impaired glucose tolerant individuals The Finnish Diabetes Prevention Study. Family history of diabetes and effectiveness of lifestyle counseling on the cardio-metabolic risk profile in individuals at high risk of type 2 diabetes: 1-year follow-up of the FIN-D2D project.
Epidemiología Cardiovascular y Nutrición
Dietary habits of the hypertensive population of Spain: in accordance with the DASH diet and the Mediterranean diet. Prevalence of generalized and abdominal obesity in the adult population of Spain, the ENRICA study.
Unidad Metabólico-Vascular
Antihypertensive efficacy and safety of olmesartan and ramipril in elderly patients with mild to moderate systolic and diastolic hypertension.
Investigación en Nutrición y Alimentos Funcionales – NUTRINVEST
Coagulopatías y Alteraciones de la Hemostasia
Iatrogenic fracture of the proximal tibia as a complication of knee manipulation under anesthesia in a hemophilia patient with an ipsilateral stiff knee secondary to a supracondylar nonunion of the femur. Late avascular necrosis of the femoral head (anfh) after percutaneous fixation of a nondisplaced fracture of the femoral neck in a hemophiliac patient with inhibitors: an unreported association.
Fisiología y Farmacología Vascular
SIDA y Enfermedades Infecciosas
Evaluation of the BinaxNOW PBP2a assay for direct detection of methicillin resistance in Staphylococcus aureus from positive blood culture vials. Cost-effectiveness analysis of GESIDA/National AIDS Plan-preferred treatments for initial antiretroviral therapy in human immunodeficiency virus (HIV)-infected adult patients in 2012. Estimating the costs of Transient Elastography ( FibroScan (R)) in the diagnosis of liver fibrosis in HIV patients with hepatitis C virus.
Detectable viral load impairs immunosenescence features of CD8 T-cell subsets in vertically HIV-infected children. Robust and sustained antiviral response to raltegravir-based highly active antiretroviral therapy in HIV-type 1-infected children and adolescents. Incidence of rash in the 96-week analysis of the combined randomized double-blind Phase III trials ECHO and THRIVE.
Registry of the Spanish network for systemic sclerosis: clinical pattern according to cutaneous subsets and immunological status.
Microbiología Molecular
Isolation, Characterization, and Lipid Properties of the FtsA Cleavage Protein from Escherichia coli.
Inmuno-Reumatología
Lack of association between TLR4 rs4986790 polymorphism and risk of cardiovascular disease in patients with rheumatoid arthritis. Lack of association between CXCL12 rs501120 polymorphism and cardiovascular disease in Spanish patients with rheumatoid arthritis. Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients.
Association of methionine sulfoxide reductase A gene rs10903323 polymorphism with cardiovascular disease in patients with rheumatoid arthritis. Association study of BAK1 gene polymorphisms in Spanish rheumatoid arthritis and systemic lupus erythematosus cohorts. Replication of the association of interleukin 23 receptor variant rs1343151 with rheumatoid arthritis in Caucasian sample groups.
Tocilizumab use patterns and dosing among patients with rheumatoid arthritis in clinical practice.
Respuesta Inmune Innata
Diagnóstico y Tratamiento de
Development in nutrition of children diagnosed with chronic kidney disease in the first two years of life. Renal transplantation in a patient with atypical hemolytic uremic syndrome with high levels of antifactor h antibodies.
Fisiopatología Linfocitaria en Inmunodeficiencias
Characterization of gamma-delta t-lymphocytes in Tab(-)T Gamma Delta plus B plus NK plus SCID DUE TO LEAKE CD3D MUTATIONS. Multicenter Study (EMPATHY) to Evaluate the Antibody Response to Salmonella Typhi for the Diagnosis of Anti-Polysaccharide Antibody Production Deficiency in Patients with Primary Immunodeficiency.
Enfermedades Respiratorias
Regulación de la Expresión Génica por Hipoxia
Nefrología
Medical therapy with tranexamic acid in patients with autosomal dominant polycystic kidney disease with severe haematuria. Creation of a platform for processing, storage and management of clinical samples: organization and development of the REDinREN Biobank. Effect of self-administered intraperitoneal bemiparin on peritoneal transport and ultrafiltration capacity in peritoneal dialysis patients with membrane dysfunction.
Effect of bicarbonate/low gdp peritoneal dialysis fluid (BICAVERA) on in vitro and ex vivo epithelial-to-mesenchymal transition of mesothelial cells. Effect of baseline characteristics of peritoneal transport, inflammation, and high glucose exposure on the prognosis of peritoneal membrane function. Inhibition of transforming growth factor-activated kinase 1 (TAK1) blocks and reverses the epithelial-to-mesenchymal transition of mesothelial cells.
Biological role, clinical significance and therapeutic potential of the recently discovered metabolic hormone fibroblastic growth factor 21.
Neonatología
Envejecimiento y Fragilidad en las Personas Mayores
Hepatología Molecular
Instituto de Genética Médica y Molecular (INGEMM)
Development of a disease-specific quality of life questionnaire for adult patients with hereditary angioedema due to C1 inhibitor deficiency (HAE-QoL): Spanish multi-center research project. Mutations in PLOD2 Cause autosomal recessive connective tissue disorders within the Bruck syndrome-osteogenesis imperfecta phenotypic spectrum. A novel dominant hyperekplexy mutation Y705C alters trafficking and biochemical properties of the presynaptic glycine transporter GlyT2.
Identification of the first PAR1 recurrent deletion in Leri-Weill dyschondrosteosis and idiopathic short stature reveals the presence of a novel SHOX enhancer. Acenocoumarol dosing algorithm using clinical and pharmacogenetic data in Spanish patients with thromboembolic disease. Functional characterization of MODY2 mutations highlights the importance of fine-tuning glucokinase and its role in glucose sensing.
RAS-MAPK gene alterations in 200 Spanish patients with Noonan and other neuro-cardio-facio-cutaneous diseases.
Implicación de los sistemas Glicérgico y Glutamatérgico en patologías del Sistema Nervioso
Genética molecular de las Distroglinopatías
Oncología Traslacional
Erlotinib versus standard chemotherapy as first-line treatment for European patients with EGFR mutation-positive advanced non-small cell lung cancer (EURTAC): a multicentre, open-label, randomized phase 3 trial. Intermarket cost comparison of erlotinib versus pemetrexed for first-line maintenance treatment of patients with locally advanced or metastatic non-small cell lung cancer. PTRF/Cavin-1 and MIF proteins identified as non-small cell lung cancer biomarkers by label-free proteomics.
Anemia-related fatigue in patients with solid tumors: a multicenter, observational, and prospective study (PACS study). Clinicopathological characteristics of non-smoking women's lung cancer (WLC): a review of the Spanish world07 database. Efficacy and safety of temsirolimus in patients with metastatic renal cell carcinoma: results from the Spanish experience.
Long-term survivors of advanced non-squamous non-small cell lung cancer (NSNSCLC) treated with first-line (1L) (CT) plus bevacizumab (B) and maintenance (MTC) B chemotherapy.
Terapias Experimentales y Biomarcadores en Cáncer
Cost-effectiveness analysis of cetuximab and panitumumab as first-line treatments for metastatic colorectal cancer in Spain. Cost effectiveness analysis per life years gained based on predictors of response for first-line treatment in metastatic colorectal cancer in Spain. Year-on-year budget impact analysis of biological therapies for first-line treatment of metastatic colorectal cancer in Spain.
Analysis of concordance in EGFR pathway status between primary tumors and related metastases of colorectal cancer patients: implications for cancer therapy.
Investigación en Otoneurocirugía
Drug delivery to the inner ear: Strategies and their therapeutic implications for sensorineural hearing loss.
Anatomía Patológica. Cáncer de Mama y Ginecológico
AHRR and NCOA2 gene fusion via a t(5;8)(p15;q13) recurrent translocation in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes. Soft tissue angiofibroma: Clinicopathologic characterization of a distinctive benign fibrovascular neoplasia in a series of 37 cases.
Mecanismos de Progresión Tumoral
Characterization of the SNAG and SLUG Domains of Snail2 in the Suppression of E-Cadherin and EMT Induction: Modulation by Serine 4 Phosphorylation. A role for the TGF beta/BMP co-receptor Endoglin in the regulation of epidermal stem cell function.
Modelos Animales y Celulares para la Detección y Caracterización de Células Madre
Clinical significance of CD81 expression by clonal plasma cells in patients with high-risk smoldering and symptomatic multiple myeloma. Clinical significance of JAK2V617F allele burden quantification in classic Ph-negative myeloproliferative neoplasms. RYBP represses endogenous retroviruses and preimplantation- and germline-specific genes in mouse embryonic stem cells.
Faecal calprotectin in allogeneic stem cell transplantation for the diagnosis of acute intestinal graft versus host disease. Non-canonical residues of the marginally stable monomeric ubiquitin conjugase of goldfish are involved in binding to the C-terminus of Ring 1B.
Cirugía de las Malformaciones Congénitas
Cirugía Experimental
Testing edible mushrooms to inhibit the pancreatic lipase activity by an in vitro digestion model. Supercritical carbon dioxide extraction of antioxidants from rosemary (Rosmarinus officinalis) leaves for use in edible vegetable oils. Comprehensive characterization of the functional activities of pressurized liquid and ultrasound-assisted extracts of Chlorella vulgaris.
Fisiopatología Ósea y Biomateriales
Terapia Celular y Genometástasis
Ingeniería Celular
Farmacología Clínica
Evaluation of the appropriate use of blood component transfusion in emergency departments: results of the first phase. Improving the appropriateness of linezolid use decreases the incidence of linezolid resistance among Gram-positives.
Grupo de Investigación sobre el Diagnóntico y Tratamiento de las Enfermedades
Clinical features and burden of hereditary angioedema: results of the Hereditary Angioedema Burden of Disease Study in Europe. Retrospective epidemiological study of angioedema attacks in patients with hereditary angioedema due to C1-INH deficiency. Burden of suspected allergy to beta-lactam antibiotics in a tertiary care hospital and the role of the allergist: a pilot study.
The economic burden of hereditary angioedema: results from the Hereditary Angioedema Burden of Disease Study in Europe. The hereditary angioedema burden of disease study in Europe, an innovative and comprehensive study from the patient perspective: background and methods. Clinical characteristics and human burden of hereditary angioedema (HAE): results from the European Burden of Disease Study (HAE-BOIS-EUROPE).
Evidence-based recommendations for the therapeutic management of angioedema due to hereditary C1 inhibitor deficiency: consensus report of an international working group.
Investigación y Diagnóstico de Enfermedades Metabólicas Hereditarias
Genetic analysis of congenital disorders of glycosylation (CDG) patients using candidate gene genomic capture and next generation sequencing.
Investgación de Cirugía OsteoArticular – GICOA
In vitro evaluation of adhesion of Staphylococcus epidermidis and Staphylococcus aureus to TiO2 nanotubes in Ti-6Al-4V alloy. Ligament histomorphometry using a general-purpose image processing software, a new strategy for semi-automated measurements. Mullins influence on compressive behavior in micelle-templated silica and micelle-templated silica/agarose systems.
Identification of an extracellular o-n-acetyl-glycosylase responsible for an increased level of o-linked modified n-acetylglucosamine proteins in the cartilage of patients with osteoarthritis.
Oftalmología
Ginecología y Obstetricia
Urgencias y Emergencias
