Effect of transcription factor NRF2 in modulating autophagy on TAU and beta-amyloid pathology in a combined mouse model of Alzheimer's disease. Effect of the transcription factor NRF2 on tau and beta-amyloid pathology in a combined mouse model of Alzheimer's disease.
Estructura, Neuroquímica y Plasticidad de los Circuitos Neuronales de la Corteza
Publicaciones
Neurobiología de la Respuesta Inflamatoria
A prognostic score to identify low-risk outpatients with acute deep vein thrombosis in the lower extremities. The impact of disseminated intravascular coagulation on the outcome of cancer patients with venous thromboembolism.
Grupo 8 – Investigación en Cardiología Clínica e Invasiva - ICCI-Paz
Should beta-blockers remain first-line treatment for patients with atrial fibrillation and heart failure? Long-term impact of blood pressure and serum glucose control in patients with type 2 diabetes.
Epidemiología Cardiovascular y Nutrición
Impact of ambulatory blood pressure monitoring on reclassification of hypertension prevalence and control in older people in Spain. Impact of ambulatory blood pressure monitoring on the control of untreated, undertreated and resistant hypertension in older people in Spain.
Unidad Metabólico Vascular
Investigación en Nutrición y Alimentos Funcionales - NUTRINVEST
Coagulopatías y Alteraciones de la Hemostasia
The pharmacokinetics of a B-domain truncated recombinant factor VIII, turoctocog alfa (NovoEight (R)), in patients with hemophilia A. Correlation between ABR and PK parameters in patients with severe hemophilia A receiving Turoctocog alfa (NOVOEIGHT (R) ) for prophylaxis.
Fisiología y Farmacología Vascular
MAPK pathway activation by chronic lead exposure increases vascular reactivity through oxidative stress/cyclooxygenase-2-dependent pathways.
SIDA y Enfermedades Infecciosas
Costs and cost-effectiveness analysis of the 2014 GESIDA/Spanish National AIDS Plan recommended guidelines for initial antiretroviral therapy in HIV-infected adults. Executive summary of the diagnosis and antimicrobial treatment of invasive infections due to multidrug-resistant Enterobacteriaceae.
Disfunción y Fallo Orgánico en la Agresión
Micafungin at a standard dose of 100 mg/day achieves adequate plasma exposure in critically ill patients with severe burns.
Microbiología Molecular
Inmuno-Reumatología
PTGER4 gene variant rs76523431 is a possible risk factor for radiological joint damage in patients with rheumatoid arthritis: a genetic study of six cohorts. Lack of association between JAK3 gene polymorphisms and cardiovascular disease in Spanish patients with rheumatoid arthritis. Effect of infliximab dose escalation in rheumatoid arthritis at different trough concentrations: a cohort study under clinical practice conditions.
Assessment of global disease activity in rheumatoid arthritis by patients and physicians: differences across countries in the METEOR database. Comparison of tapering strategy with standard dosing regimen of tumor necrosis factor inhibitors in patients with spondyloarthritis in low disease activity. 2014 update of the consensus statement of the Spanish Society of Rheumatology on the use of biological therapies in rheumatoid arthritis.
Use and dosing patterns of tocilizumab in the treatment of patients with rheumatoid arthritis in routine clinical practice: the ACT-LIFE study. Consensus statement on a framework for the management of comorbidity and extra-articular manifestations in rheumatoid arthritis.
Respuesta Inmune Innata
Usefulness of nicotinic receptor alpha 7 messenger RNA levels in peripheral blood mononuclear cells as a marker for cholinergic antiinflammatory pathway activity in septic patients: results of a pilot study. Regulation of MicroRNA 183 by cyclooxygenase 2 in the liver is dependent on DEAD-Box Helicase p68 (DDX5): Role in insulin signaling. In vivo domestication and genetic evolution of an ST247-SCCmecl MRSA clone after 13 years of bronchopulmonary pathogen colonization in a patient with cystic fibrosis: implications for the innate immune response.
Reply to "In vivo attenuation and genetic evolution of an ST247-SCCmecI MRSA clone after 13 years of pathogenic bronchopulmonary colonization in a patient with cystic fibrosis: implications of the innate immune response".
Diagnóstico y Tratamiento de
Zarauza-Santovena, A., ha ambuekuéra. Fernández-Camblor, C., ha ambuekuéra. Rock-Carrion, A., ha ambuekuéra. Ruiz-Hernández, F., ha ambuekuéra. Hernández-Zuniga, L., ha ambuekuéra. Melgosa-Ta’ýra, M., ha ambuekuéra. Alonso-Melgar, A., ha ambuekuéra. García-Meseguer, C., ha ambuekuéra. Spinosa-Romano, L. Zarauza-Santovena, A., ha ambuekuéra. Fernández-Camblor, C., ha ambuekuéra. Rock-Carrion, A., ha ambuekuéra. Hernández-Zuñiga, L., ha ambuekuéra. Ruiz-Hernández, F., ha ambuekuéra. Melgosa-Ta’ýra, M., ha ambuekuéra. Alonso-Melgar, A., ha ambuekuéra. García-Meseguer, C., ha ambuekuéra. Spinosa-Romano, L. (1999) Ñe’ẽ reko ha rekosã’ỹ rehegua.
Fisiopatología Linfocitaria en Inmunodeficiencias
Enfermedades Respiratorias
Efficacy of home single-channel nasal pressure to recommend continuous positive airway pressure treatment for sleep apnea. Prospective validation of prognostic classifications in patients (pts) progressing to first-line chemotherapy for metastatic transitional cell carcinoma (mTCC).
Regulación de la Expresión Génica por Hipoxia
Nefrología
Early leukocyte activation antigen cd69 limits peritoneal fibrosis by regulating helper 17/regulatory t cell balance.
Neonatología
Bacteriological, biochemical and immunological properties of colostrum and mature milk from mothers of extremely preterm infants. Effects of different arachidonic acid supplements on psychomotor development in very preterm infants; a randomized controlled trial.
Envejecimiento y Fragilidad de las Personas Mayores
Consumption trends for specific drugs used to treat dementia in the Madrid region (Spain) from 2002 to 2012. Five-year incidence of chronic kidney disease (stages 3-5) and associated risk factors in a Spanish cohort: the MADIABETES study. Health-related quality of life of Latin American immigrants and Spanish-born individuals receiving Spanish primary health care: Socio-demographic and psychosocial factors.
Trends in the prevalence of depression in hospitalized patients with type 2 diabetes in Spain: analysis of hospital discharge data from 2001 to 2011. Common mental disorders in primary care: differences between Latin American-born and Spanish-born residents in Madrid, Spain . Standardized nursing care plans in patients with type 2 diabetes mellitus: are they effective in the long term.
Variations in parathyroid hormone concentration in patients with low 25 hydroxyvitamin D and its correction in patients with hip fracture.
Hepatología Molecular
Efficacy and safety of sebelipase alfa in children and adults with lysosomal acid lipase deficiency: results of a phase 3 study. Patterns of lymphocyte subsets and plasma cytokine levels reflect the adaptation of the immune system after pediatric liver transplantation - first results of the epltn network.
Instituto de Genética Médica y Molecular (INGEMM)
Specific variants in WDR35 cause a characteristic form of Ellis-van Creveld syndrome with impaired recruitment of the EvC and SMO complex to the cilium. The identification of a fourth duplication of upstream IHH regulatory elements in a family with Philadelphia-type craniosynostosis helps define the phenotypic characterization of these regulatory elements. Genetic and phenotypic characterization of families with familial pancreatic cancer and screening of high-risk individuals.
Implicación de los Sistemas Glicérgico y Glutamatérgico en Patologías del Sistema Nervioso
Oncología Traslacional
Role of surgery in patients with recurrent, metastatic or unresectable locally advanced gastrointestinal stromal tumors sensitive to imatinib: a retrospective analysis of the Spanish group for research on sarcoma (GEIS). Evaluation of the efficacy and safety of lanreotide in combination with targeted therapies in patients with neuroendocrine tumors in clinical practice: a retrospective cross-sectional analysis. Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer.
Biomarker testing in advanced non-small cell lung cancer: a national consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology. Correlation of hypertension and proteinuria with outcome in elderly bevacizumab-treated patients with metastatic colorectal cancer. Efficacy and safety of Temsirolimus in patients with metastatic renal cell carcinoma: final results of the Spanish experience.
Final results of a phase II study evaluating oral vinorelbine as a single agent as first-line chemotherapy for metastatic breast cancer patients with bone metastases (NorBreast-228 trial). Simulation and comparison of progression-free survival among patients with non-squamous non-small cell lung cancer receiving sequential therapy.
Terapias Experimentales y Biomarcadores en Cáncer
Investigación en Otoneurocirugía
Impact on prognosis of regional distribution of MGMT methylation in relation to CpG island methylator phenotype and age in glioma patients. Pros and cons of round window vibroplasty in open cavities: audiologic, surgical, and quality-of-life outcomes. Epigenetic regulation of human hedgehog-interacting protein in glioma cell lines and primary tumor samples.
Long-term functional outcomes and quality of life after open partial laryngectomy and nonsurgical laryngeal preservation.
Anatomía Patológica. Cáncer de Mama y Ginecológico
Dual therapy with atazanavir-ritonavir plus lamivudine versus triple therapy with atazanavir-ritonavir plus two nucleo(t)ides in virologically stable patients with HIV-1 (SALT): 48-week results of a randomized, open-label, non-inferiority trial.
Mecanismos de Progresión Tumoral
Modelos Animales y Celulares para la Detección y Caracterización de Células Madre
Efficacy and safety of dasatinib in early chronic phase CML patients with a late suboptimal response to first imatinib. Oral anticoagulant therapy for the prevention of recurrent thrombosis in patients with polycythemia vera or essential thrombocythemia.
Cirugía de las Malformaciones Congénitas
Cirugía Experimental
Extraction of functional components from spinach (Spinacia oleracea L.) by liquid solvent and supercritical CO2 extraction. High catechin/low caffeine powder from green tea leaves by pressurized liquid extraction and supercritical solvent precipitation. Supercritical fluid extraction of heather (Calluna vulgaris) and evaluation of anti-hepatitis C virus activity of extracts.
Fisiopatología Ósea y Biomateriales
Ingeniería Celular
Florida cystic mullerianosis of the testes: a new pathologic entity arising from a distinct Mullerian differentiation of the testicular vaginal mesothelium. A 15-year review of renal tumors in native kidneys of patients with end-stage renal disease. A rare case of renal angiomyoadenomatous tumor/clear cell (tubular) papillary carcinoma associated with secondary amyloidosis.
Eosinophilic variant of chromophobe renal cell carcinoma: Clinical, macroscopic, histological and immunohistochemical data on five cases.
Farmacología Clínica
Grupo de Investigación sobre el Diagnóntico y Tratamiento de las Enfermedades
Treatment of HAE attacks in the Icatibant Outcome Survey: an analysis of Icatibant self-administration versus administration by healthcare professionals. Component-free diagnosis of baker's allergy based on specific IgE to recombinant wheat flour proteins. Aspirin desensitization achieved after omalizumab treatment in a patient with aspirin-exacerbated urticaria and respiratory disease.
Occupational allergic bronchial asthma caused by Lallzyme EX-V, an enzyme mixture derived from Aspergillus niger used as an additive in the wine industry. Icatibant Outcomes Study: More than 2,200 attacks treated with icatibant in patients with hereditary angioedema type i or ii. Icatibant Outcome Survey: Triggering factors and predictive symptoms of angioedema attacks in patients with hereditary angioedema.
Icatibant Outcome Survey: observational data in patients with angioedema due to acquired C1 inhibitor (C1-INH) deficiency. Icatibant Outcome Survey: more than 1500 attacks treated with icatibant in patients with hereditary angioedema type I or II.
Investigación y Diagnóstico de Enfermedades Metabólicas Hereditarias
Investgación de Cirugía OsteoArticular – GICOA
CORR Insights (R): recycling analysis of sequentially annealed highly cross-linked polyethylene used in total hip arthroplasty. CORR Insights (R): Revision of metal-on-metal hip prostheses results in marked reduction of blood cobalt and chromium ion concentrations. The paracrine relationships that mesenchymal stem cells establish with osteoblasts and endothelial cells are influenced by biomaterial characteristics.
Knee fusion or above-knee amputation after failed two-stage reimplantation of total knee arthroplasty.
Oftalmología
Ginecología y Obstetricia
The effect of a triple therapy on maternal anti-Ro/SS-A levels associated with fetal cardiac manifestations.
Urgencias y Emergencias
Hipersensibilidad a Medicamentos y Respuesta Inmune Innata
