Carotid artery intima-media thickness as a marker of small or large vessel disease in ischemic stroke. Lack of response to conventional glucose management in patients with acute ischemic stroke and the sequelae of stroke.
Estrategias Neuroprotectoras en Enfermedades Neurodegenerativas
Publicaciones
Estructura, Neuroquímica y Plasticidad de los Circuitos Neuronales de la Corteza
Classification of mild cognitive impairment and Alzheimer's disease with machine learning techniques using H-1 magnetic resonance spectroscopy data.
Medicina Interna y Enfermedades Sistémicas
Acute respiratory distress syndrome after recovery from plasma use: treatment of a patient with Ebola virus disease acquired in Madrid, Spain. The impact of disseminated intravascular coagulation on the outcome of cancer patients with venous thromboembolism.
Grupo 8 – Investigación en Cardiología Clínica e Invasiva - ICCI-Paz
Long-term effects of blood pressure and serum glucose control in patients with type 2 diabetes mellitus. Effects of a cardiac rehabilitation program in patients with severe left ventricular dysfunction: everyone can benefit from it.
Epidemiología Cardiovascular y Nutrición
Differences between classes of drugs and between drugs belonging to the same class .JOURNAL OF CLINICAL HYPERTENSION. Impact of ambulatory blood pressure monitoring on the reclassification of hypertension prevalence and control in the elderly in Spain.
Unidad Metabólico Vascular
Investigación en Nutrición y Alimentos Funcionales - NUTRINVEST
Hormonas Sexuales y Función Vascular
Coagulopatías y Alteraciones de la Hemostasia
The pharmacokinetics of a truncated recombinant factor VIII in the B domain, turoctocog alfa (NovoEight (R)), in patients with hemophilia A. Correlation between ABR and PK parameters in patients with severe hemophilia A receiving Turoctocog alfa (NOVOEight (R) )) to get.
Fisiología y Farmacología Vascular
MAPK pathway activation by chronic lead exposure increases vascular reactivity through oxidative stress/cyclooxygenase-2-dependent pathways. The intimate alteration of human varicose veins is associated with oxidative stress and cyclooxygenase-2 dependent mechanisms.
SIDA y Enfermedades Infecciosas
Cost and cost-effectiveness analysis of the 2014 GESIDA/Spanish National AIDS Plan recommended guidelines for initial antiretroviral therapy in HIV-infected adults. Summary of the diagnosis and antimicrobial treatment of invasive infections due to multidrug-resistant Enterobacteriaceae. Summary of the GESIDA/National AIDS Plan Consensus Document on Antiretroviral Therapy in Adults Infected with Human Immunodeficiency Virus (updated January 2015).
Dual treatment with atazanavir-ritonavir plus lamivudine versus triple treatment with atazanavir-ritonavir plus two nucleosides in virologically stable patients with HIV-1 (SALT): 48-week results from a randomized, open-label, non-inferiority study ( vol. 15, p. 775, 2015).
Disfunción y Fallo Orgánico en la Agresión
Continuous tissue glucose monitoring correlates with intermittent capillary glucose measurement in patients with distributive shock. Micafungin at a standard dose of 100 mg/day achieves adequate plasma exposure in critically ill patients with severe burn injuries.
Microbiología Molecular
Human papillomavirus mRNA testing for the detection of anal high-grade squamous intraepithelial lesions in men who have sex with men infected with HIV. Development of a reference database for the identification of Histoplasma capsulatum by MALDI-ToF mass spectrometry.
Inmuno-Reumatología
Lack of association between JAK3 gene polymorphisms and cardiovascular disease in Spanish patients with rheumatoid arthritis. Assessment of global disease activity in rheumatoid arthritis by patients and physicians: differences between countries in the METEOR database. A truncated variant of ASCC1, a novel inhibitor of NF-kappa B, is associated with disease severity in patients with rheumatoid arthritis.
Consensus statement on a framework for the management of comorbidity and extra-articular manifestations in rheumatoid arthritis.
Respuesta Inmune Innata
Usefulness of nicotinic receptor alpha 7 messenger RNA levels in peripheral blood mononuclear cells as a marker for cholinergic antiinflammatory pathway activity in septic patients: results of a pilot study. Regulation of MicroRNA 183 by cyclooxygenase 2 in the liver is dependent on DEAD-Box Helicase p68 (DDX5): Role in insulin signaling. In vivo domestication and genetic evolution of an ST247-SCCmecl MRSA clone after 13 years of bronchopulmonary pathogen colonization in a patient with cystic fibrosis: implications for the innate immune response.
Response to "In vivo attenuation and genetic evolution of a ST247-SCCmecI MRSA clone after 13 years of pathogenic bronchopulmonary colonization in a patient with cystic fibrosis: implications of the innate immune response".
Diagnóstico y Tratamiento de
Heterogeneity but individual constancy of epitopes, isotypes, and avidity of factor H autoantibodies in atypical hemolytic uremic syndrome. Mutations of the Cl-inhibitor gene (SERPING1) associated with hereditary angioedema: Impact on biological parameters associated with the target proteases. Eculizumab treatment in de novo atypical hemolytic uremic syndrome after renal transplantation associated with complete deficiency of factor-h-related proteins 1 and 3.
Zarauza-Santovena, A.; Fernández-Camblor, C.; Peña-Carrion, A.; Ruiz-Hernández, F.; Hernández-Zúñiga, L.; Melgosa-Hijosa, M.; Alonso-Melgar, A.; García-Meseguer, C.; Espinosa-Román, L.
Fisiopatología Linfocitaria en Inmunodeficiencias
Enfermedades Respiratorias
Effects of weight loss after bariatric surgery on pulmonary function tests and obstructive sleep apnea in morbidly obese women. Prognostic value of six-second spirometry in patients with chronic obstructive pulmonary disease: a cohort study. Effectiveness of single-channel nasal pressure at home in recommending continuous positive airway pressure therapy in sleep apnea.
Prospective validity of prognostic classifications in patients (pts) progressing on first-line chemotherapy in metastatic transitional cell carcinoma (mTCC).
Regulación de la Expresión Génica por Hipoxia
Nefrología
Bioimpedance vector analysis as a tool for determining and adjusting dry weight in patients undergoing hemodialysis. An increase in plasma levels of advanced oxidation protein products is associated with cardiovascular risk in incident peritoneal dialysis patients: a pilot study. The evaluation of the efficacy and safety of three dosing regimens of agalsidase alpha enzyme replacement therapy was underpowered.
Early leukocyte activation antigen cd69 limits peritoneal fibrosis by regulating helper 17/regulatory t cell balance.
Neonatología
Evaluation of cytomegalovirus infection in breast milk-fed low-birth-weight infants using a real-time polymerase chain reaction assay. Bacteriological, biochemical and immunological characteristics of colostrum and mature milk from mothers of extremely preterm infants. Effects of different arachidonic acid supplementation on psychomotor development in very preterm infants; a randomized controlled trial.
Envejecimiento y Fragilidad de las Personas Mayores
Consumption trends for specific drugs used to treat dementia in the Madrid region (Spain) from 2002 to 2012. Trends in the prevalence of depression in patients hospitalized with type 2 diabetes in Spain: analysis of hospital discharge data from 2001 to 2011. Standardized nursing Care plans in patients with type 2 diabetes mellitus: Are they effective in the long term.
Variations in parathyroid hormone concentration in patients with low 25 hydroxyvitamin D and its correction in patients with hip fracture.
Hepatología Molecular
Efficacy and safety of sebelipase alfa in children and adults with lysosomal acid lipase deficiency: results of a phase 3 trial. Patterns of lymphocyte subsets and plasma cytokine levels reflect immune system adaptation after pediatric liver transplantation - first results from the epltn network.
Instituto de Genética Médica y Molecular (INGEMM)
Specific variants in WDR35 cause a characteristic form of Ellis-van Creveld syndrome by disrupting the recruitment of the EvC complex and SMO into the cilium. Profiling of conserved non-coding elements upstream of SHOX and functional characterization of the SHOX cis-regulatory landscape. Identification of the fourth duplication of upstream IHH regulatory elements, in a family with craniosynostosis Philadelphia type, helps to define the phenotypic characterization of these regulatory elements.
Genetic and phenotypic characterization of families with familial pancreatic cancer and screening of high-risk individuals.
Implicación de los Sistemas Glicérgico y Glutamatérgico en Patologías del Sistema Nervioso
Oncología Traslacional
Correlation of hypertension and proteinuria with outcome in elderly patients with metastatic colorectal cancer treated with bevacizumab. Efficacy and safety of temsirolimus in patients with metastatic renal cell carcinoma: Final results of the Spanish experience. Final results of a phase II study evaluating oral vinorelbine as a single agent as first-line chemotherapy in patients with metastatic breast cancer with bone metastases (NorBreast-228 trial).
Simulation and comparison of progression-free survival in patients with non-squamous non-small cell lung cancer receiving sequential therapy.
Terapias Experimentales y Biomarcadores en Cáncer
Investigación en Otoneurocirugía
Impact on prognosis of regional distribution of MGMT methylation in relation to CpG island methylator phenotype and age in glioma patients. Pros and cons of round window vibroplasty in open cavities: audiological, surgical, and quality of life outcomes. Epigenetic regulation of human hedgehog-interacting protein in glioma cell lines and primary tumor samples.
Long-term functional results and quality of life after open partial laryngectomy and nonsurgical laryngeal preservation.
Patología Molecular del Cáncer y Dianas Terapéuticas
Laparoscopic Sentinel Node Biopsy Using Real-Time 3-Dimensional Single-Photon Emission Computed Tomographic Guidance in Endometrial Cancer. Dual therapy with atazanavir-ritonavir plus lamivudine versus triple therapy with atazanavir-ritonavir plus two nucleo(t)ides in virologically stable patients with HIV-1 (SALT): 48-week results of a randomized, open-label, non-inferiority trial. Intraoperative molecular assessment for sentinel lymph node metastasis in endometrial carcinoma using one-step nucleic acid amplification (OSNA) assay.
Mecanismos de Progresión Tumoral
A role for the transducer of the Hippo pathway, TAZ, in the development of aggressive types of endometrial cancer.
Modelos Animales y Celulares para la Detección y Caracterización de Células Madre
Clinical implications of the presence of mutations in patients with chronic myeloid leukemia (LMC) resistant to imatinib. Evaluation of the brenutximab vedotin regimen and eshap (BRESHAP) in primary resistant Hodgkin's lymphoma or at first relapse: results before a trial phase. Induced lymphocytosis after dasatinib intake is associated with the inhibition of lymphocytic migration and alteration of chemokine receptor expression, and such inhibition appears to be associated with an early response.
Oral anticoagulant therapy for the prevention of recurrent thrombosis in patients with polycythemia vera or essential thrombocythemia.
Cirugía de las Malformaciones Congénitas
Cirugía Experimental
Extraction of functional ingredients from spinach (Spinacia oleracea L.) using liquid solvent and supercritical CO2 extraction. ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage II colon cancer patients. High catechins/low caffeine powder from green tea leaves by pressurized liquid extraction and supercritical antisolvent precipitation.
Supercritical fluid extraction of heather (Calluna vulgaris) and evaluation of anti-hepatitis C virus activity of the extracts.
Fisiopatología Ósea y Biomateriales
Ingeniería Celular
Blatant cystic Mullerianosis of the testis: a new pathological entity originating from a distinct Mullerian differentiation of the testicular vaginal mesothelium. A 15-year review of renal tumors in native kidneys of patients with end-stage renal disease. A rare case of renal angiomyoadenomatous tumor/papillary clear cell (tubulo)carcinoma associated with secondary amyloidosis.
Eosinophilic variant of chromophobe renal cell carcinoma: clinical, macroscopic, histological and immunohistochemical data on five cases.
Farmacología Clínica
Grupo de Investigación sobre el Diagnóntico y Tratamiento de las Enfermedades
The icatibant outcome survey: more than 2200 icatibant-treated seizures in patients with type i or ii hereditary angioedema. The Icatibant Outcome Survey: More than 1500 Icatibant-treated seizures in patients with type I or II hereditary angioedema. The Icatibant Outcome Survey: Observational data in patients with angioedema due to acquired C1-inhibitor (C1-INH) deficiency.
The Icatibant Outcome Survey: Trigger Factors and Predisposing Symptoms of Angioedema Attacks in Patients with Hereditary Angioedema.
Investigación y Diagnóstico de Enfermedades Metabólicas Hereditarias
Carnitine-acylcarnitine translocase deficiency: experience with four cases in Spain and literature review. Functional characterization of the spf/ash splicing variation in otc deficiency in mice and humans.
Investgación de Cirugía OsteoArticular – GICOA
CORR Insights (R): recycling analysis of sequentially annealed highly cross-linked polyethylene used in total hip arthroplasty. CORR Insights (R): Revision of metal-on-metal hip prostheses results in marked reduction of blood cobalt and chromium ion concentrations. The paracrine relationships that mesenchymal stem cells establish with osteoblasts and endothelial cells are influenced by biomaterial characteristics.
Knee fusion or above-knee amputation after failed two-stage reimplantation Total knee arthroplasty.
Oftalmología
Ginecología y Obstetricia
Workplace educational climate in gynecologic oncology fellowships across Europe impact of accreditation. Effect of triple therapy on maternal anti-Ro/SS-A levels associated with fetal cardiac manifestations.
Urgencias y Emergencias
Dual therapy with lopinavir-ritonavir plus lamivudine versus triple therapy with lopinavir-ritonavir plus lamivudine or emtricitabine and a second nucleos(t)ide reverse transcriptase inhibitor for maintenance of HIV-1 viral suppression (OLE): a randomized, open-label, non-inferiority trial.
Hipersensibilidad a Medicamentos y Respuesta Inmune Innata
