Carbosilane dendrimers
Synthesis of chiral carbosilane dendrimers with L cysteine and N acetyl L cysteine on their surface and their application as chiral selectors for enantiomer separation by capillary electrophoresis
... Chiral carbosilane dendrimers have been obtained through the inclusion of chiral centers on the dendritic ...to dendrimers with terminal olefin functionalities as we have previously ...
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Polyanionic carbosilane dendrimers as a new adjuvant in combination with latency reversal agents for HIV treatment
... polyanionic carbosilane dendrimers in the context of latent HIV‑1 ...these dendrimers in combination with latency reversal agents (LRAs) against HIV‑1 ...
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Synthesis of degradable cationic carbosilane dendrimers based on Si O or ester bonds
... degradable carbosilane dendrimers, we have designed new cationic systems through two different strategies: with inner Si-O bonds or with peripheral ester ...of dendrimers has been prepared by ...
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Structure activity relationship study of cationic carbosilane dendritic systems as antibacterial agents
... on dendrimers, since a lower concentration value means a higher activity of this cationic function, also reflecting the importance of multivalency in the overall activity of the ...cationic carbosilane ...
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Fluorescein labelled cationic carbosilane dendritic systems for biological studies
... of carbosilane dendrimers and water-soluble cationic derivatives have been used as delivery vectors, 48-52 binding oligonucleotides and siRNA and transporting them to the interior of a range of cell ...
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Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity
... 20 since dendron aggregates cannot be formed. But also Signal 2 disappears in the nanocomposites 8b and 9b. This effect may arise from two sources. First, the binding of the dendron to Au in the AuNPs subtracts binding ...
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Self Assembly behavior of amphiphilic janus dendrimers in water: a combined experimental and coarse grained molecular dynamics simulation approach
... all dendrimers (Figure ...[G-2] dendrimers, probably because of the size of their structure that difficult the rapid arrangement of the dendrimer molecules into more stable ...phases. Dendrimers 5A, ...
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Self Assembly Behavior of Amphiphilic Janus Dendrimers in Water: A Combined Experimental and Coarse Grained Molecular Dynamics Simulation Approach
... Janus dendrimers (JDs) are repetitively branched molecules with hydrophilic and hydrophobic components that self-assemble in water to form a variety of morphologies, including vesicles analogous to liposomes with ...
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Antibacterial Effect of Carbosilane Metallodendrimers in Planktonic Cells of Gram Positive and Gram Negative Bacteria and Staphylococcus aureus Biofilm
... The results indicate that carbosilane metallodendrimers are also effective inhibitors of the formation of S. aureus biofilms. Copper metallodendrimer 2, with nitrate ligands, kept the potent bacteriostatic and ...
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Amphiphilic Cationic Carbosilane PEG Dendrimers: Synthesis and Applications in Gene Therapy
... amphiphilic dendrimers composed of two types of dendrons, one based on the carbosilane moiety and the other on a PEG scaffold, both decorated with ammonium groups at their ...these dendrimers was ...
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Strategies for penicillin V dendronization with cationic carbosilane dendrons and study of antibacterial properties
... for dendrimers and generation two for dendrons with six and four ammonium groups, respectively) against both gram-positive and gram-negative bacteria and also against resistant ...
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In Vitro anticancer properties of copper metallodendrimers
... of dendrimers on the cell membrane, the degree of haemolysis was ...[13]. Carbosilane copper dendrimers caused haemolysis after 24 h of incubation, the intensity of haemolytic effect depended on ...
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Controlled drug delivery strategies: Advances on the synthesis and molecular dynamics of dendrimers, and optimization of liposomes preparation by Dual Asymmetric Centrifugation
... site-specific dendrimers as an alternative of drug delivery systems, with potential use as carriers of highly active drugs like ...site-specific dendrimers with bis-MPA as branching precursor and three key ...
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Self Assembly of Amphiphilic Dendrimers: The Role of Generation and Alkyl Chain Length in siRNA Interaction
... G2-13C dendrimers are not able to form micelles that efficiently bind to siRNA due to shorter alkyl chains that promote the formation of less stable Figure ...
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Nanomaterials and Nanosystems for Biomedical Applications – M. Reza Mozafari
... PAMAM-based dendrimers that selectively target cancer ...polyamidoamine dendrimers conjugated to different biofunctional moieties (fluorescein and folic acid), and then linked them together using ...
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Synthesis and electrochemical characterization of donor-acceptor phenylazomethine dendrimers
... The synthesis of the first donor–acceptor phenylazomethine dendrimers (4 and 5) is described. A convergent method is used via the condensation of aromatic ketones with an appropriately functionalized ...
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Effect of Terminal Groups of Dendrimers in the Complexation with Antisense Oligonucleotides and Cell Uptake
... PAMAM-OH dendrimers do not have toxic effects in in vitro and in in vivo applications ...of dendrimers, and at the same time, to build effective nucleic-acid car- ...PAMAM dendrimers have been also ...
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Mesoporous Silica Nanoparticles Decorated with Carbosilane Dendrons as New Non viral Oligonucleotide Delivery Carriers
... However, the delivery of foreign nucleic acids into the interior of a cell is not an easy task and needs to overcome several biological obstacles that prevent the therapeutic delivery of DNA/siRNA. For instance, the ...
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Carbosilane cationic dendrimers synthesized by thiol ene chemistry and their use as antibacterial agents
... The combination of QAS with macromolecules generates polycations that present high superficial charge. Different types of these macromolecules such as polymers, 14 dendrimers, 15 and hyperbranched polymers 16 have ...
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Function Oriented Molecular Design: Dendrimers as novel antimicrobials
... that dendrimers have shown the ability to inhibit biofilm ...Antimicrobial dendrimers have been shown to be capable of preventing bacterial adhesion to surfaces, therefore, limiting subsequent biofilm ...
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