Clinical trials

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Rare diseases and the assessment of intervention: What sorts of clinical trials can we use?

Rare diseases and the assessment of intervention: What sorts of clinical trials can we use?

... randomized trials of treatment (versus no treatment) of ...`Randomized trials or observational tribulations' (Pocock and Elbourne, 2000) and commented on two articles showing no di¡erence in estimated ...

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HOPE Desarrollo de una metodología piloto para vinculación a Clinical Trials como herramienta de medicina basada en evidencias, para proporcionar medicina centrada en el paciente

HOPE Desarrollo de una metodología piloto para vinculación a Clinical Trials como herramienta de medicina basada en evidencias, para proporcionar medicina centrada en el paciente

... de clinical trials. Con la colaboración de médicos especialistas de Chihuahua, México se obtuvo información clínica de pacientes reales en tratamiento paliativo. Con el apoyo de Ingeniera de España, Europa ...

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Liver safety assessment: required data elements and best practices for data collection and standardization in clinical trials.

Liver safety assessment: required data elements and best practices for data collection and standardization in clinical trials.

... in clinical trials of agents being developed to treat non-malignant conditions, the presence of tumor-associated hyperbiliru- binemia with or without AT elevations would not neces- sarily disqualify study ...

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Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials

Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials

... the clinical use of MSCs as an opportunity for tissue repair and regeneration in several neurodegeneratives ...of clinical trials for drugs in development can be divided into four ...first ...

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Composite endpoints in clinical trials : computational tools, practical guidelines and methodological extensions

Composite endpoints in clinical trials : computational tools, practical guidelines and methodological extensions

... Composite endpoints, consisting of the union of two or more outcomes, are often used as the primary endpoint in time-to-event randomized clinical trials. Previously, G ´omez and Lagakos provided a method to ...

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An Ontology Based Method to Solve Query Identifier Heterogeneity in Post-Genomic Clinical Trials

An Ontology Based Method to Solve Query Identifier Heterogeneity in Post-Genomic Clinical Trials

... Clinico-Genomic Trials on Cancer (ACGT) is a European Commission- supported project that aims to develop a set of ontology-driven technologies to support the development of treatment and research within ...

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Artificial Pancreas: first clinical trials in Argentina

Artificial Pancreas: first clinical trials in Argentina

... animal trials (Kovatchev et al., 2008, 2009). Very recently, clinical trials were per- formed in different countries of the EU, USA, Israel and Australia (Hovorka et ...

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Efficacy of cryotherapy for the treatment of cutaneous leishmaniasis: meta analyses of clinical trials

Efficacy of cryotherapy for the treatment of cutaneous leishmaniasis: meta analyses of clinical trials

... for clinical, demo- graphic and parasitological ...controlled clinical trials and to improve local evi- dence, adjusted for the clinical, parasitological, and therapeutic characteristics ...

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Protective role of carvedilol to prevent left ventricular systolic dysfunction in patients under chemotherapy: a systematic review and meta analysis of randomized clinical trials

Protective role of carvedilol to prevent left ventricular systolic dysfunction in patients under chemotherapy: a systematic review and meta analysis of randomized clinical trials

... longitudinal strain in half of the patients immediately after anthracyclines treatment, without left ventricular ejection fraction deterioration. Chemotherapy is in fact, the clinical stage where left-ventricular ...

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PEDro or Cochrane to assess the quality of clinical trials? A meta-epidemiological study

PEDro or Cochrane to assess the quality of clinical trials? A meta-epidemiological study

... for trials to be included in sys- tematic reviews and ...of trials, Greenland [10], Colle [70], and Juni and colleagues [11] showed that using different tools for evaluating quality of primary research in ...

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Responsability of sponsors after clinical trials are finished

Responsability of sponsors after clinical trials are finished

... Abstract: This paper describes some ethical problems derived from multi center studies in developing countries, specifically those referred to the role of sponsors after the clinical trial is concluded. After ...

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Long term randomized clinical trials of pharmacological treatment of obesity: Systematic review

Long term randomized clinical trials of pharmacological treatment of obesity: Systematic review

... The authors (LMCG and RCS) conducted a review of the articles registered in PUBMED, SCIELO, and EBSCOHOST published in English and Spanish with the following search data: «1999/01/01»: «2008/12/31» and «Obesity ...

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Ensayos clínicos, Estado y sociedad: ¿dónde termina la ciencia y empieza el negocio?

Ensayos clínicos, Estado y sociedad: ¿dónde termina la ciencia y empieza el negocio?

... of clinical trials are related to the control of chronic diseases or pre-morbid states (such as diabetes, asthma, dyslipidemia and hypertension) generates a generally captive market, with business stability ...

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Intravenous immunoglobulin plus corticosteroid to prevent coronary artery abnormalities in Kawasaki disease: a meta-analysis

Intravenous immunoglobulin plus corticosteroid to prevent coronary artery abnormalities in Kawasaki disease: a meta-analysis

... Several clinical trials have been performed to investigate the ef fi cacy of corticosteroid in Kawasaki disease 11–27 ; however, the role of a corticosteroid in the initial treatment of Kawasaki disease has ...

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Vol. 90, Núm. 6 (2019)

Vol. 90, Núm. 6 (2019)

... controlled clinical trials, analytical (cases and controls, and cohorts), and non- analytical (prevalence) with diagnosis of CD and DS with keywords in English (celiac disease and Down syndrome) and in ...

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Amyloid beta immunotherapy: the hope for Alzheimer disease?

Amyloid beta immunotherapy: the hope for Alzheimer disease?

... Alzheimer disease (AD) is the most prevalent form of dementia of adult-onset, characterized by progressive impairment in cognition and memory. There is no cure for the disease and the current treatments are only ...

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Disponibilidad y barreras a la adopcin de prcticas basadas en la evidencia para el tratamiento del uso de sustancias en Mxico

Disponibilidad y barreras a la adopcin de prcticas basadas en la evidencia para el tratamiento del uso de sustancias en Mxico

... We would like to specially thank the site principal investigators of the first trial implemented in the Mexican Clinical Trials Network, Ricardo Sánchez Huesca, Ph.D.; Carlos Lima Rodriguez Rodríguez, M.D.; ...

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Papel del consejo intensivo para la cesacin de fumar  Estudio prospectivo multicausal en centros de Atencin Primaria de Salud

Papel del consejo intensivo para la cesacin de fumar Estudio prospectivo multicausal en centros de Atencin Primaria de Salud

... randomized clinical trials reported differing results for effectiveness of medication (bupropion SR) and nicotine replacement therapy (NRT) (patch, gum, inhaler) as first- line treatment of smoking ...

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Estimulacin cerebral no invasiva en las enfermedades neurolgicas y psiquitricas

Estimulacin cerebral no invasiva en las enfermedades neurolgicas y psiquitricas

... included clinical trials with scientific evidence on the use of transcranial stimulation with direct current and repetitive transcranial magnetic stimulation in neurological and psychiatric diseases, until ...

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Cuatro palabras sobre ensayos clínicos: ciencia/negocio, riesgo/beneficio

Cuatro palabras sobre ensayos clínicos: ciencia/negocio, riesgo/beneficio

... conducting clinical trials with vioxx in order to confirm its supposed benefits and to test its efficacy for the treatment of other diseases such as colon ...from clinical trials? once it was ...

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