Connexin hemichannels
Cell membrane permeabilization via connexin hemichannels in living and dying cells
... express connexin hemichannels (Cx HCs) at their ...form hemichannels and increase the cell membrane permeability but are not addressed in this ...showing connexin, cell and cell stage ...via ...
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Hunting for connexin hemichannels
... of hemichannels present in the cell ...homomeric connexin hemichannels were identified and found to have approx- imately twice the conductance of the corresponding gap junction channels ...
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FGF 1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels
... express pannexin 1 (Px1) and purinergic receptors. Fibroblast growth factor 1 (FGF-1), which is released in spinal cord injury, acti- vated spinal astrocytes in culture, induced secretion of ATP, and per- meabilized them ...
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Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca2+ signaling in HeLa cells
... Gap junction channels (GJCs) and hemichannels (HCs) are composed of protein subunits termed connexins (Cxs) and are permeable to ions and small molecules. In most organs, GJCs communicate the cytoplasm of adjacent ...
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Connexin and pannexin hemichannels in inflammatory responses of glia and neurons
... these hemichannels is not connected with a hemichannel in another membrane and opens to the exterior, is it still a hemichannel? Or has it become a channel? Clearly it is a channel, but we prefer not to change the ...
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Pannexin channel and connexin hemichannel expression in vascular function and inflammation
... through connexin hemichannels [78, ...of hemichannels formed by the vascular connexins Cx37, Cx40 and Cx43, probably through S-nitrosylation, as demonstrated in the case of Cx43 hemichannels ...
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Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases
... astroglial hemichannels and pannexons characterizes the last few ...Although hemichannels and pannexons initially appeared to be one of the many cellular mechanisms used by astrocytes to share their ...
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The Neuroglial Dialog Between Cannabinoids and Hemichannels
... that hemichannels and pannexons play pivotal roles at the normal CNS, including the establishment of adhesive interactions, tolerance to ischemia, fear memory consolidation, glucose and redox sensing, ...
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Hemichannels; from the molecule to the function
... Cx43 hemichannels by the actin/myosin contractile systems may be considered, including a direct or indirect link between Cx43 hemichannels and the actin/myosin cytoskeleton (Ponsaerts et ...of ...
123
Glial hemichannels and their involvement in aging and neurodegenerative diseases
... glial hemichannels as potential regulators of the beginning and maintenance of homeostatic imbalances observed in diverse brain ...glial hemichannels on neuro- degenerative ...glial hemichannels, ...
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Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes
... Figure 2. HIV increases the activity of Panx1 hemichannels in human primary CD4 ⴙ T lymphocytes. (A) Total levels of Panx1 in CD4 ⫹ T lymphocytes under control conditions (Ctrl) or after transfection for 48 h with ...
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Role of gap junctions and hemichannels in parasitic infections
... Panx-formed hemichannels, since they are present in erythrocytes, are permeable to molecules such a purines, and exhibit anion-like channel activity when expressed in mammalian cells [91, ...Panx1 ...
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Regulation of intercellular calcium signaling through calcium interactions with connexin based channels
... In the last decade, a new pathway for exchange of ions and molecules between the intra and extracellular milieu constituted by connexin HCs has received progres- sive attention [ 11 ] . For a long time, the HC ...
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Regulation of Hemichannels and Gap Junction Channels by Cytokines in Antigen Presenting Cells
... Copyright © 2014 Pablo J. S´aez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
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HIV increases the release of dickkopf 1 protein from human astrocytes by a Cx43 hemichannel dependent mechanism
... Human immunode fi ciency virus-1 (HIV) is a public health issue and a major complication of the disease is NeuroAIDS. In vivo , microglia/macrophages are the main cells infected. However, a low but signi fi cant number of ...
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Regulation of pannexin and connexin channels and their functional role in skeletal muscles
... Abstract Myogenic precursor cells express connexins (Cx) and pannexins (Panx), proteins that form different membrane channels involved in cell-cell communication. Cx channels connect either the cytoplasm of adjacent ...
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TítuloMecanismos de comunicación celular en cartílago articular y su implicación en el desarrollo de la artrosis
... Single hemichannels allow cells to interchange components with the matrix, and Cx43 has been reported to form functional hemichannels in a wide variety of mammalian cell ...Cx43 hemichannels were ...
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Amyloid beta Induced Death in Neurons Involves Glial and Neuronal Hemichannels
... Astroglial Cx43 expression is increased at amyloid plaques from patients with AD (Nagy et al., 1996; Mei et al., 2010), whereas connexin-mediated astroglial networks and in vivo intercellular calcium waves are ...
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Connexin43 hemichannels in satellite glial cells, can they influence sensory neuron activity?
... After the experimental procedure, increased neuronal activity and dye transfer between SGCs was observed. The higher increment in neuronal activity triggered by the procedure was suppressed by three different GJC ...
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S Nitrosylation and Permeation Through Connexin 43 Hemichannels in Astrocytes: Induction by Oxidant Stress and Reversal by Reducing Agents
... are hemichannels formed of wild-type Cx43, and this permeability is decreased by PKC-mediated phosphorylation (36), suggesting that those amino acid residues are not relevant for the normal activity of Cx43 ...of ...
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