... The diagnostic criteria are the presence of morning stiffness, arthritisof three or more joint areas, arthritisof the hand joints, symmetric arthritis, rheumatoid ...
... (secondary), of which the most frequent are Hashi- moto’s thyroiditis and rheumatoidarthritis ...spectrum of the disease may extend from an organ specific autoimmune disorder (autoimmune ...
... number of subjects in the house- hold [24]), history of RA in a first-degree relative, smoking history (self-reported ever or never), disease duration, the ACR core set of variables (number of ...
... prevalence of clinically evident interstitial lung disease in patients with rheumatoidarthritis is approximately ...33% of undiagnosed patients have interstitial lung abnormalities that can ...
... limitation of the present study is the small sample ...none of the patients were followed up from the beginning of treatment with one anti-TNF until a change to a different one; as such, there may ...
... region of highly similar sequence among certain HLA-DR class II alleles, is the best-known genetic factor as- sociated with ...region of DR chains, especially amino acids 70–74, encoding a conserved amino ...
... maintenance of inflammation in multiple autoimmune and 13 nonautoimmune ...number of large placebo-controlled trials have shown that infliximab, a chimeric monoclonal 14 antibody against TNF-a, is effective ...
... review of the impact of medication regimen factors on adherence to chronic treatment showed that in most of the therapeutic areas evaluated (with the exception of asthma/pulmonary disease), ...
... to develop TB when using these agents, especially with Infliximab, as demonstrated in a Meta- analysis. Guidelines proposing the screening of latent tuberculosis infection risk before initiation of ...
... levels of ACPAs, and this finding may explain the association with less severe disease ...progression of joint damage has been related to levels of ACPAs, both in RA patients [39,40] and in animal ...
... Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis.. Zimmerli W, Trampuz A, Ochsner P.[r] ...
... (Department of Dermatology, Hospital Universitario Infanta Leonor, Madrid, Spain), Alba Erra (Hospital Sant Rafael, Barcelona, Spain), Carlos M González (Hospital General Universitario Gregorio Marañón, Madrid, ...
... influence of autoantibody status on the asso- ciation of the five IL6R tagSNPs with joint damage (Table S2 in Additional file ...significance of IL6R SNPs with this disease severity ...
... El diagnóstico de la AR es una combinación de signos, síntomas, pruebas biológicas y pruebas de imagen. Existen criterios de clasificación de la AR que han mostrado buena sensibilidad y especificidad para diagnosticar ...
... failure of remyelination in patients with MS is poorly understood, it has been suggested that (i) oligodendrocyte precursor cells may be destroyed or (ii) the pool of these precursor cells is exhausted or ...
... damage ofrheumatoidarthritis ...destruction of cartilage and bone. The main current therapies of RA are focused against inflammatory factors and immune cells; however, a significant ...
... time of evolution, seropositivity, erosions and smoking. Reproducibility of the association across these differences suggests that it is robust and that could be confirmed in additional ...applicability ...
... ARTRITE REUMATÓIDE E SAÚDE MENTAL Há mais de 100 anos que a AR figura como um desafio para profissionais da área da saúde, sendo que as formas de prevenção, tratamento e cura não estão totalmente estabelecidas e parecem ...
... American RheumatoidArthritis Con- sortium I (NARAC-I)) for significant heterogeneity of PTPN22 association in function of the SNP ...subset of the NARAC-I sample with a more uniform ...
... activity of the disease and the GSSG ...possibility of a higher GR ac- tivity in ...presence of high concentra- tions of the substrate while GPx acts at low concen- trations, which suggests an ...