DNA damage

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Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition

Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition

... damaged DNA has remained enigmatic until ...lowing DNA damage, each ATM molecule phosphorylates the other on a serine residue at position 1981 within the FAT domain, a phosphorylation that releases ...

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Use of the comet test to assess DNA damage in children with ataxia-telangiectasia and their relatives.

Use of the comet test to assess DNA damage in children with ataxia-telangiectasia and their relatives.

... cell damage can be estimated using various techniques ...assess DNA damage in lymphocytes from children with ataxia-telangiectasia, and to measure chromosomal instability within the ...of DNA ...

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Radiation induced apoptosis and initial DNA damage are inversely related in locally advanced breast cancer patients.

Radiation induced apoptosis and initial DNA damage are inversely related in locally advanced breast cancer patients.

... residual DNA damage ...radiation-induced DNA damage suggests that variation in cell radiosensitivity can be detected in vitro using radiosensitivity assays on PBLs from normal tissues of ...

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Acute aerobic exercise does not cause DNA damage in trained individuals after a running session

Acute aerobic exercise does not cause DNA damage in trained individuals after a running session

... Villañoa et al., 2015). On the other hand, continuous practice with progressive intensities can induce adaptive responses by increasing the efficiency of endogenous antioxidant systems. In addition, it has been shown ...

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Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes

Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes

... the damage inflicted directly by radiation, producing irreversible changes during DNA replica- tion or cell division or during the processing of DNA damage by enzymatic repair processes ...

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Environmental polycyclic aromatic hydrocarbon (PAH) exposure and DNA damage in Mexican children

Environmental polycyclic aromatic hydrocarbon (PAH) exposure and DNA damage in Mexican children

... of organic matter [1]. Exposure to these ubiquitous environmen- tal contaminants is a public health problem in cities with high industrial activity and heavy vehicular traffic, and also in some rural communities, due to ...

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ADN daado y capacidad de reparacin en pacientes con neurofibromatosis tipo 1

ADN daado y capacidad de reparacin en pacientes con neurofibromatosis tipo 1

... oxidation-induced DNA damage, and repair capacity in lymphocytes of NF1 patients compared to healthy control ...in DNA damage were observed between controls and patients (p > ...but ...

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Evaluacin del dao inmediato al DNA en trabajadores ocupacionalmente expuestos a bajas dosis de radiacin ionizante mediante ensayo cometa

Evaluacin del dao inmediato al DNA en trabajadores ocupacionalmente expuestos a bajas dosis de radiacin ionizante mediante ensayo cometa

... of DNA damage, detectable within the first hours after exposure of the ...early DNA lesions caused by exposure to low doses of ionizing radiation in 41 workers from the departments of Radiology, ...

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TítuloEarly Genotoxic and Cytotoxic Effects of the Toxic Dinoflagellate Prorocentrum lima in the Mussel Mytilus galloprovincialis

TítuloEarly Genotoxic and Cytotoxic Effects of the Toxic Dinoflagellate Prorocentrum lima in the Mussel Mytilus galloprovincialis

... oxidative DNA damage. In addition, the DNA damage observed in gill cells seems to be mainly influenced by exposure time and ...oxidative damage found in hemocytes exposed in vitro to ...

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Comet Assay, a New in vivo

Comet Assay, a New in vivo

... that DNA damage in the SEpC located on the luminal surface occurred due to the effects of the 2,6- ...though DNA damage has occurred in the SEpC, taking into account that the life- time of ...

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The X ray repair cross complementing protein 1 (XRCC1) rs25487 polymorphism and susceptibility to cirrhosis in Brazilian patients with chronic viral hepatitis

The X ray repair cross complementing protein 1 (XRCC1) rs25487 polymorphism and susceptibility to cirrhosis in Brazilian patients with chronic viral hepatitis

... Introduction. The progression of hepatic disease in chronic viral hepatitis is accompanied by an increased production of reactive oxygen species (ROS), as well as an accumulation of oxidative DNA damage, ...

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Combinatorial antitumor effect of HDACs and the PI3K Akt mTOR pathway inhibition in a Pten deficient model of prostate cancer

Combinatorial antitumor effect of HDACs and the PI3K Akt mTOR pathway inhibition in a Pten deficient model of prostate cancer

... in DNA damage we observed in PC3-AR cells in response to ...induce DNA damage via double strand breaks (DSBs) to mediate their transcriptional ...by DNA repair machinery such as poly ...

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Protective effect of a phytocompound on oxidative stress and DNA fragmentation against paracetamol induced liver damage

Protective effect of a phytocompound on oxidative stress and DNA fragmentation against paracetamol induced liver damage

... mitochondrial damage can lead to direct or indirect oxida- tive DNA damage and it has been found that a significant accumulation of the potentially mutagenic DNA lesion ei- ther at sub-toxic ...

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The balance between fumarate and malate plays an important role in plant development and postharvest quality in tomato fruit

The balance between fumarate and malate plays an important role in plant development and postharvest quality in tomato fruit

... It has been indeed proposed that the associated accumulation of fumarate competitively inhibits the 2-oxoglutarate-dependent dioxygenases that regulate hypoxia-inducible factor (HIF), thus activating oncogenic hypoxia ...

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Rat DNA polymerase beta substitutes the repairing activity of DNA polymerase I in the lethal effect of UV light

Rat DNA polymerase beta substitutes the repairing activity of DNA polymerase I in the lethal effect of UV light

... for DNA polymerase I during DNA replication in Escherichia ...rat DNA polymerase beta replace both the replicative and repair (BER) functions of DNA polymerase I in Escherichia coli (Sweasy ...

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Mutacion del dna y traduccion del dna

Mutacion del dna y traduccion del dna

... Es muy común encontrar en los libros las definiciones de gen, muchas veces leerán, secuencia de DNA que codifica una proteína, eso es parcialmente falso. Porque hay genes que no codifican proteínas, algunos genes ...

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Environmental liability

Environmental liability

... concerning damage caused by nuclear activities, as well as in the field of oil pollution at ...with damage caused by maritime transport of hazard- ous and noxious substances and also by transboundary ...

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Periimplantitis: Checkerboard DNA-DNA Hybridization Método para la Identificación de Bacterias Patógenas

Periimplantitis: Checkerboard DNA-DNA Hybridization Método para la Identificación de Bacterias Patógenas

... 1998). DNA Checkerboard method offers the ability to include more potential periodontal pathogens in large-scale studies with a single analysis than is usually practicable with cultural ...

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Estudio de proteínas recombinantes usando como modelo de expresión ovocitos de xenopus laevis

Estudio de proteínas recombinantes usando como modelo de expresión ovocitos de xenopus laevis

... de DNA foráneo en células de cultivo, el empleo de uno u otro método depende en gran medida de tipo celular que se emplee, del objetivo del estudio, el tamaño y naturaleza del gen a introducir, la economía del ...

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La hematologa en la era de la medicina aeroespacial: cambios hematolgicos en los astronautas

La hematologa en la era de la medicina aeroespacial: cambios hematolgicos en los astronautas

... There are metabolic changes like weight, fluid and electrolyte loss. There could be certain endocrine disorders, such as sleep disturbances and disrup- ted circadian rhythm. Most astronauts experience problems with ...

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