Dopaminergic neurons
Relationship between the afferent innervation pattern and the spontaneous and aversive stimulus driven activity of individual VTA dopaminergic neurons
... of neurons) and the amount of tissue and thus, the number profiles that we could stereologically count, with the aim of improving the statistic power of our ...more neurons (12 neurons compared to ...
151
Generation of human dopaminergic neurons from induced pluripotent stem cells to model Parkinson's disease
... mDA neurons are born is characterized by the presence of two instructive signals: fibroblast growth factor 8 (FGF8) expressed at the midbrain-hindbrain border (isthmus) and sonic hedgehog (SHH) expressed in the ...
111
La atorvastatina protege las neuronas gabérgicas y dopaminérgicas del sistema nigroestriatal en un modelo experimental de isquemia cerebral focal transitoria en ratas
... GABAergic neurons and is located near the putamen, immediately outside the internal capsule; this region can be further divided into the globus pallidus lateral (GpL) and the globus pallidus medial (GpM) ...
11
The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism.
... of dopaminergic neurons (Ungerstedt, 1968; Schwarting and Huston, 1996) because this neurotoxin acts through the generation of reactive oxygen species (ROS) (Cohen et ...nigral dopaminergic ...
14
Adolescent cannabinoid exposure increases nigrostriatal dopaminergic transmission
... the dopaminergic transmission in the mesolimbic and nigrostriatal pathways are strongly associated with the reinforcing effects of drug of abuses and the development of addictive ...in dopaminergic ...
121
Enfermedad de parkinson: aspectos moleculares terapia restaurativa y neuroproteccin
... Figue 3. Mechanisms of neurodegeneration in Parkinson´s disease. The accumulation of misfolded proteins is likely to be a key event in PD neurodegeneration. Pathogenic mutations may directly induce abnormal protein ...
12
Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1
... a recently described AAV construct to overexpress XBP1s under the control of the CMV promoter (AAV XBP1s/EGFP) (36, 40). Unilateral injections of AAV XBP1s/EGFP into the SNpc led to high expression of xbp1s mRNA in this ...
6
Pleiotrophin overexpression regulates amphetamine induced reward and striatal dopaminergic denervation without changing the expression of dopamine D1 and D2 receptors: Implications for neuroinflammation / M Vicente Rodríguez [et al ]
... damages dopaminergic neurons, causing striatal dopaminergic denervation and dopaminergic cell death in the substantia nigra among other effects (Moratalla et ...and dopaminergic ...
28
Relevance of both type 1 and type 2 corticotropin releasing factor receptors in stress induced relapse to cocaine seeking behaviour
... noradrenergic neurons in the brain stem A1 (ventrolateral medulla, VLM) and A2 (nucleus of the solitary tract, NTS) noradrenergic neuronal ...ergic neurons have axon collaterals innervating the BNST and the ...
5
Angiotensin type 1 receptor antagonists protect against alpha synuclein induced neuroinflammation and dopaminergic neuron death
... of dopaminergic neurons and α -synuclein accumulation are major hallmarks of Parkinson ’ s disease (PD), and it has been suggested that a major mechanism of α-synuclein toxicity is microglial ...marked ...
19
An alarm pheromone increases the responsivity of amygdaline hippocampal neurons
... According to our results, amygdaline-hippocampal neurons seem to be sensitive to one-assay learning. Behav- ioral studies using 2-heptanone as alarm pheromone are scarce, but the use of predator odors, i.e., ...
6
Measuring mechanical properties of touch receptor neurons using optical tweezers
... Krieg, et. al. [2] summarize the sense of touch as follows: forces applied to the skin surface are transmitted quickly and reliably to Mechano-electrical Transduction (MeT) channels embedded within specialized sensory ...
65
Cholinergic abnormalities, endosomal alterations and up regulation of nerve growth factor signaling in Niemann Pick Type C disease
... To further elucidate the mechanism by which NPC1 -/- cholinergic neurons are sensitized to NGF signaling, we established a cell culture model of NPC by treating PC12 cells with the drug U18666A. PC12 cells are a ...
18
16643835
... To distinguish between D1 and D5 subtypes, the action of agonists in the D1/D5 receptor family was first investigated on rat subtha- lamic neurons. Single-cell reverse transcription-PCR profiling showed that ...
10
Phosphorylated tau potentiates A beta induced mitochondrial damage in mature neurons
... In its hyperphosphorylated form, tau appears to block mitochondrial transport, resulting in energy deprivation and oxidative stress (Ittner et al., 2010; Reddy, 2011). Further studies showed that overexpression of ...
10
PAPER BOLSA DE VALORES -IA.pdf
... The Architecture of the Artificial Neural Networks Model proposed in this work is MFNN (Multilayer Feedforward Neural Networks) and is shown in Figure 2.3. This consists of an input layer, an output layer, and at least ...
8
Dopaminergic stimulation of myeloid antigen presenting cells attenuates signal transducer and activator of transcription 3 activation favouring the development of experimental autoimmune encephalomyelitis
... the dopaminergic system in PBMCs obtained from MS patients (33, ...of dopaminergic alterations in MS patients confined to T-cells revealed an associa- tion of MS manifestation with the capability of Tregs ...
16
Frizzled Receptors in Neurons: From Growth Cones to the Synapse
... Wnt signaling is activated by the interaction of a Wnt ligand with members of the Frizzled (Fz) family of seven- pass transmembrane cell-surface receptors [Gordon and Nusse, 2006; Schulte, 2010]. In addition to the 10 Fz ...
7
Wnt 5a Modulates Recycling of Functional GABA(A) Receptors on Hippocampal Neurons
... The Wnt signaling pathway has been involved in various cel- lular processes, including functions in the neuronal development and maintenance of the nervous system (Lie et al., 2005; Ahmad- Annuar et al., 2006; Chen et ...
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