Drug-Induced
Drug induced liver injury: do we still need a routine liver biopsy for diagnosis today?
... of drug induced liver injury (DILI) is challenging, because histopathologi- cal features mimic all primary hepatic and biliary diseases, lacking changes that are specific for ...herb induced liver ...
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Drug induced liver injury secondary to interferon beta (IFN β) in multiple sclerosis
... of drug induced hepatic injury, care should be taken when switch- ing from one IFN β to another, or from one disease-modi- fying drug to ...offending drug in moderate to severe hepatitis could ...
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Drug induced liver injury in hospitalized HIV patients: high incidence and association with drugs for tuberculosis
... Background. The evaluation of liver disease in HIV patients is cumbersome because may result from a num- ber of different causes. The aim of this retrospective study was to estimate the incidence of severe drug ...
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Drug induced liver injury: accuracy of diagnosis in published reports
... We searched the Medline database in March 2013 with the following terms: drug hepatotoxicity, drug induced liver injury, and hepatotoxic drugs. For each term, we used the first 100 publications ...
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Association of GST null genotypes with anti tuberculosis drug induced hepatotoxicity in Western Indian population
... This case-control study in Western Indian popula- tion analyzed the association between GSTM1 and GSTT1 homozygous null mutations and anti-TB drug induced hepatotoxicity. The homozygous GSTM1 null genotype ...
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NAT2 genetic polymorphisms and anti tuberculosis drug induced hepatotoxicity in Chinese community population
... Before anti-tuberculosis therapy, serum hepatitis B virus surface antigen, serum alanine transamina- se (ALT), aspartate amino transaminase (AST), di- rect and total bilirubin levels, renal function, blood and urine ...
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Drug Induced Liver Injury at a Tertiary Hospital in India: Etiology, Clinical Features and Predictors of Mortality
... The comparison of clinical features between survivors and non-survivors is shown in table 4. Jaundice, dark colored urine, encephalopathy, acute kidney injury and as- cites were significantly associated with higher ...
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The influence of drug properties and host factors on delayed onset of symptoms in drug induced liver injury
... factors, drug properties and their interactions influencing a DILI phenotype by using a large DILI data set from the Spanish DILI ...factors, drug properties and their specific interactions play a role in ...
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LncRNA Regulated Autophagy and its Potential Role in Drug Induced Liver Injury
... damage induced by different drugs may have varied pathways, the central factors are the reactive metabolites, resulting in abnormal proteins or organelles interfering with the normal physiological ...stress- ...
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Profile of idiosyncratic drug induced liver injury in Latin America An analysis of published reports
... A literature search was performed using the online version of MEDLINE, EMBASE, Scopus, Google Scholar and specific data bases from LA (Scielo, Lilacs) to identify any case report or case series of published DILI from ...
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Drug induced fatty liver disease: An overview of pathogenesis and management
... in hepatocytes without causing appreciable hepatic inflammation, liver cell death, or scarring. At the midrange of the severity spectrum is steatohepatitis (nonalcoholic steatohepatitis, or NASH), which is an ...
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Overview on the mechanisms of drug induced liver cell death
... that it is the number of mitochondria developing MPT that activates the necrotic or the apoptotic death process in the presence of an uncoupling effect of the drug on the mito- chondrial oxidative phosphorylation. ...
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Hepatoprotective Role of Thymol in Drug Induced Gastric Ulcer Model
... may be the reason of Indo-induced harmful effects on the liver. Thymol treatment decreased eNOS level, indicating that Thymol could attenuate Indo-induced liver injury (Figure 1D). This was also confirmed ...
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A concise and structured review of drug induced toxic hepatic disease
... particular drug is another adverse effect but in this case it is not related to the dose ...particular drug generating it and the adverse reaction deals with the point of view of the pa- tient to whom it is ...
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Drug-induced autoimmune liver disease: A diagnostic dilemma of an increasingly reported disease.
... 18 Weiler-Normann C, Schramm C. Drug induced liver injury and its relationship to autoimmune hepatitis. J Hepatol 2011; 55: 747-749 [PMID: 21396413 DOI: 10.1016/j.jhep.2011.02.024] 19 Lucena MI, Molokhia M, ...
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Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America
... fixed drug eruption (FDE), a positive PT or IDT would not change management recommendations, and would therefore probably not be incorporated into ...manifestation, drug to PT, and PT materials to make PTs ...
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Evidencia de la exposición a fármacos citostáticos del personal sanitario: revisión de la literatura reciente
... provides a less accurate description of the places from which samples were taken, there is a reference to selec- ting the settings so that the whole work circuit was re- presented, from drug unpacking, preparation ...
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Ketorolac pharmacokinetics in experimental cirrhosis by bile duct ligation in the rat
... oral drug bioavailability in liver damage can be explained by an impaired drug transfer from the gastrointestinal lumen to the splachnic circulation, by drug transfer to ascitis fluid before arrival ...
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Sndrome DRESS
... El síndrome DRESS (drug reaction with eosinophilia and systemic symptoms), también llamado síndrome de hipersensibilidad inducido por fármacos (drug-induced hyper- sensitivity syndrome, DiHS), es una ...
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Reaccin por drogas con eosinofilia: Sndrome DRESS, un gran simulador
... o drug re- action with eosinophilia and systemic symptoms ( DRESS ) treated with pulse intravenous ...of Drug Rash with Eosinophilia and Systemic Symptoms and Stevens-Johnson ...
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