Elastin-like recombinamers
Engineering responsive and biomimetic material based on elastin like recombinamers for biomedical application
... on elastin were successfully obtained by using standard chemical processes as demonstrated by Urry, Prasad and others (11,12), but some problems arise when more complex structures or simply larger polymers want to ...
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Bone regeneration mediated by a bioactive and biodegradable ECM like hydrogel based on elastin like recombinamers
... and elastin-like polypeptides, have been developed over the last few decades with the aim of improving the features of traditional biomaterials in terms of ease of design and synthesis, biocompatibility and ...
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Recent Contributions of Elastin-Like Recombinamers to Biomedicine and Nanotechnology
... biomaterials, Elastin-like Recombinamers (ELRs) have demonstrated their enormous potential in the fields of biomedicine and nanoscience in the last few ...their elastin-based origin (mainly ...
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Novel Hydrogel forming elastin like recombinamers for biomedical applications
... find elastin-like polypeptides (ELPs), which have also been recently termed elastin-like recombinamers (ELRs), according to their recombinant ...
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Layer by layer biofabrication of coronary covered stents with clickable elastin like recombinamers
... The elastin-like recombinamers (ELRs) are a family of artificial polymers bioinspired by the pentapeptide VPGVG present in the natural elastin [18, ...
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Trends in the design and use of elastin-like recombinamers as biomaterials
... silk-elastin-like recombinamers (SELRs) that are able to form fibers and hydrogels, among other structures, whose stability relies on the β-sheet cross-linking between silk-like motifs [8, 71, ...
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Synthesis and characterization of amphiphilic elastin-like recombinamers: Development of self-assembling nanoparticles and hydrogels
... so-called elastin like recombinamers (ELRs), taking into account its recombinant nature this new nomenclature was proposed 6 in replacement of the more conventional terminology elastin- ...
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Nanogel Formation from Dilute Solutions of Clickable Elastin like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes
... Elastin-like recombinamers (ELRs) are proteinaceous bio- materials based on the repetition of certain sequences from natural elastin 1,2 ...
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Nanotechnological Approaches to Therapeutic Delivery Using Elastin Like Recombinamers
... particular, elastin-like recombinamers stand out due to the possibility of incorporating virtually any peptide-function present (or not) in any natural protein into their composition, thus making ...
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Stimuli-responsive systems based on elastin-like recombinamers for biomedical applications
... The main target of this work is to explore the feasibility of tuning and controlling the shape and topology of self-assembled nano-objects in recombinant LCST-based macromolecules, avoiding the use of rigid segments with ...
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Bioengineered dynamic systems based on elastin like recombinamers
... surface and ablated strips showed no major differences. Consequently, these strips were functionalized with the optimized mixture (75% CCCREDV- 25% CC-RGD). No topographic differences has been found among the ...
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FRET Paired Hydrogel Forming Silk Elastin Like Recombinamers by Recombinant Conjugation of Fluorescent Proteins
... Cloning and heterologous expression of the SELRs used in this work were performed as described elsewhere. 32 Briefly, their full-length DNA sequences, including FPs, were obtained by the iterative recursive method ...
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Elastin like recombinamers as smart drug delivery systems
... The aforementioned recombinant nature of ELRs permits a strict control over their physical and chemical properties, thus allowing the tailoring of their self-assembly into different structures, such as different types of ...
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Bicyclic RGD peptides with high integrin α<sub>v</sub>β<sub>3</sub> and α<sub>5</sub>β<sub>1</sub> affinity promote cell adhesion on elastin like recombinamers
... 2 adhesion and proliferation analysis using the PicoGreen® assay revealed a higher short-term adhesion and proliferative capacity of cells on ELR surfaces functionalized with high affi[r] ...
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Biofunctional hydrogels based on elastin like recombinamers as extracellular matrix analogues
... The presence of ELRs in these ELR-FGs was corroborated by Immunofluorescence staining with streptavidin TRIC (red stain) and Alexa Fluor 488 (green stain). Several samples of Fibrin gels, ELR- FGs and ovine carotid ...
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Elastin like recombinamers multilayered nanofibrous scaffolds for cardiovascular applications
... uncrosslinked mats were done for 1, 4 and 7 days. Results are shown in fi gure 9. Incubation of HUVECs on top of sterilized fiber mats show no cytotoxicity, regardless of the time. At 24 h there is a high prolifera- tion ...
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Aggregation behaviour of biohybrid microgels from elastin like recombinamers
... Microgels are intramolecularly cross-linked synthetic or bio- polymeric chains with colloidal dimensions that can be built from a large variety of different monomers or amino acids. 1,2 The presence of the hydrophilic and ...
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3D silicon doped hydroxyapatite scaffolds decorated with Elastin like Recombinamers for bone regenerative medicine
... ELRs are based on repeated sequences, namely “elastomeric domains”, found in an extracellular matrix (ECM) protein, the natural elastin [8,9][8,9]. ELRs retain the elastin mechanical properties, specially ...
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Accessing new biomedical applications by combining genetic design and chemical modification of elastin like recombinamers
... In CTA0, the hydrophobicity of the substrate only changed (from 72° to around 95°) when heating above 25°C. The cholesteryl-containing samples had three states of hydrophobicity, with the first at around 72° at 15°C ...
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Elastin like recombinamers with acquired functionalities for gene delivery applications
... How- ever, the death effect was visibly higher in cells treated with polyplexes containing LAELIK120CPP at ratios of 80/1 and 120/1 in comparison with IK120 polyplexes and untreated cont[r] ...
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