Gene therapy
Gene therapy of liver cancer
... most gene therapy approaches is the cost and technical difficulties for the large scale production of the ...difficulties, gene therapy may play an important role as an adjuvant of other ...
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Axicabtagene ciloleucel, Gene Therapy against Non Hodgking Lymphoma pdf
... During that same month of June, a contractor from Florida, Eric Karlson, suffering from a non-Hodgkin lymphoma, became the first patient treated with what would become KTE-C19 gene therapy. Even though his ...
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Biocompatible ELR Based Polyplexes Coated with MUC1 Specific Aptamers and Targeted for Breast Cancer Gene Therapy
... in gene therapy is to use 906 the natural killer ability of cytotoxic agents or cell death 907 inducers to selectively eliminate undesirable cells, 75 the 908 expression of a ribosome inactivating protein ...
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Genetic manipulation of the pancreas: cell and gene therapy approaches for type 1 diabetes
... Gene therapy may provide new treatments for severe pancreatic ...However, gene transfer to the pancreas is difficult because of its anatomic location and structure, and pancreatitis is a serious ...
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A double safety lock tumor specific device for suicide gene therapy in breast cancer
... endocrine therapy available, which have been shown to improve the clinical outcome, the cure rate has not increased and mastectomy is often also required, thus causing significant psychological sequelae in ...
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Gene Therapy for Treatment of Chronic Hyperammonemia in a Rat Model of Hepatic Encephalopathy
... transduced with Bac-GS showed a specific sharp band with a molecular weight of 44 kDa, which corresponds to the size of GS (Figures 1A and 1B). HeLa cells were also efficiently transduced by Bac-GFP (Figure 1C). To ...
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Genomic medicine in Mexico Applications of gene therapy for cirrhosis reversion
... Genomic medicine represents a powerful armamentari- um to tackle down most of chronic diseases which have not, so far, defeated. Thus, this new and powerful bio- technologic set of weapons enable us to make use of mo- ...
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Towards autotrophic tissue engineering: Photosynthetic gene therapy for regeneration
... Compared to other eukaryotic cells, the use of microalgae as a vehicle could have an important impact on gene therapy, primarily because their survival does not depend on external oxygen supply. Besides, in ...
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Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long term mutant Huntingtin repression in mice
... safe gene therapy vec- tors, with reduced immunogenicity [1], low insertional capabilities [2], and new and more effective delivery strategies [3, 4], has led to several successful clinical tri- ...a ...
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First Gene Therapy Against Lymphoblastic Leukaemia pdf
... The Food and Drug Administration's "committee of experts" also heard the case of a child, Connor, who, like Emily is 12 years old. His father, Don McMahon, described how his son debuted with leukaemia at the age ...
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5-Fluorouracil-loaded poly(ε-caprolactone) nanoparticles combined with phage E gene therapy as a new strategy against colon cancer
... suicide gene E (combined ...of gene E from the phage φX174 was tested by generating a stable clone ...E gene expression sensitized colon cancer cells to the cytotoxic action of the 5-FU-based ...E ...
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Gene therapy: medical treatment, eugenics or inheritanceõs hygiene?
... tres continentes presentaron en Bruselas la primera secuencia genética completa de una planta (Proyecto Regia: Regulatory Gene Iniciative in Arabidopsis). Se trata de la oruga o Arabidopsis thaliana, que tiene en ...
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Amphiphilic Cationic Carbosilane PEG Dendrimers: Synthesis and Applications in Gene Therapy
... by gene therapy has grown as consequence of increased knowledge about the molecular pathways of diseases and the human ...genome. Gene therapy involves guiding functional genetic material, ...
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Immunotherapy for liver tumors: present status and future prospects
... of gene therapy strategies, allowing local production of IL-12 at the tumor milieu and resulting in high local levels with low systemic con- centrations ...IL-12 gene transfer for liver tumors ...
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Importancia de la polietilenimina en biomedicina y sus aplicaciones en terapia génica
... that gene therapy is currently one with most ...of therapy is based on using genetic material as an active substance against various pathologies and it is on which this literary review is ...
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Genetic susceptibility to hepatoxicity due to bosentan treatment in pulmonary hypertension
... Patient characteristics are summarized in table 1. The sex distribution between the groups of patients with and without elevation of transaminases during therapy with bosentan was slightly skewed. Age, body mass ...
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Genetic variation in Interleukin 28B predicts SVR in hepatitis C genotype 1 Argentine patients treated with PEG IFN and ribavirin
... 10. McCarthy JJ, Li JH, Thompson A, Suchindran S, Lao XQ, Patel K, et al. Replicated association between an IL28B gene variant and a sustained response to pegylated inter- feron and ribavirin. Gastroenterology ...
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Response to Infliximab in Crohn's Disease: Genetic Analysis Supporting Expression Profile.
... published gene expression signature regarding response to IFX in ulcerative colitis patients ...overlapping gene between the two predictive top-five gene sets in both clinical forms of ...
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TítuloA combined transcriptomic and genomic analysis identifies a gene signature associated with the response to anti TNF therapy in rheumatoid arthritis
... The set-based genetic association analysis is a powerful approach to test the association between groups of biologically-related genes and complex traits (59, 60). Using this analytical strategy we have successfully ...
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TítuloVariation at interleukin 6 receptor gene is associated to joint damage in rheumatoid arthritis
... efficacious therapy in RA, significantly reducing structural damage ...the gene encoding IL-6R is a strong candidate for association with the level of joint destruction in ...
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