INGENIERÍA VIAL
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Synthesis, biological evaluation and molecular modeling of arylfurans as potential trypanothione reductase inhibitors.
... POTENTIAL TRYPANOTHIONE REDUCTASE ...enzyme trypanothione reductase (TR) is considered a validated molecular target for the development of new drugs against this ...
Arylfurans as potential Trypanosoma cruzi trypanothione reductase inhibitors
... The natural lignans veraguensin and grandisin have been reported to be active against Trypanosoma cruzi bloodstream forms. Aiming at the total synthesis of these and related compounds, we prepared three 2-arylfurans and ...
Trypanothione reductase: a target protein for a combined in vitro and in silico screening approach.
... With the goal to identify novel trypanothione reductase (TR) inhibitors, we performed a com- bination of in vitro and in silico screening approaches. Starting from a highly diverse com- pound set of 2,816 ...
A potent trypanocidal component from the fungus Lentinus strigosus inhibits trypanothione reductase and modulates PBMC proliferation
... The fungus Lentinus strigosus (Pegler 1983) (Polyporaceae, basidiomycete) was selected in a screen for inhibitory activity on Trypanosoma cruzi trypanothione reductase (TR). The crude extract of L. ...
A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity.
... trypanosome. These include a phenotypic screen that interrogat- ed a library of FDA-approved drugs for anti-trypanosomal activity [16], as well as screens developed to identify inhibitors of essential parasite enzymes. A ...
MATERIAL AND METHODS Sample collection
... Fungal crude extracts active ( 90%) against the recombinant enzyme trypanothione reductase (TryR) and tested against amastigote forms of Trypanosoma cruzi.. b TryR = recombinant enzyme[r] ...
ISSN 0100-879X BIOMEDICAL SCIENCES AND CLINICAL INVESTIGATION
... Trypanothione reductase (TR) is an essential enzyme specific for the parasitic protozoa of the order ...glutathione/glutathione reductase system is replaced by trypanothione and ...of ...
4- Sulfide Bridged Tetranuclear CuZ Cluster in N2 O Reductase: pH
... DFT calculations, which include the lysine residue near the Cu I Cu IV edge support this model, since the calculations yield a similar SD distribution for the Cu Z cluster (as observed[r] ...
EFFECTS OF SALICYLIC ACID ON THE ANTIOXIDANT ENZYMES ACTIVITY IN SUNFLOWER
... The plants treated with salicylic acid increased the activity of enzymes such as catalase, peroxidase, superoxide dismutase, ascorbate peroxidase, glutathione reductase etc (Mano[r] ...
Activity of the Respiratory Chain Enzymes of Blood Leucocytes’ Mitochondria Under the Conditions of Toxic Hepatitis Induced Against the Background Alimentary Deprivation of Protein
... NADH-ubiquitin reductase, a marker of the Complex I of respiratory chain activity, and succinate dehydrogenase, key enzyme of the Complex II of respiratory ...NADH-ubiquitin reductase and succinate ...
Electron transfer biochemistry: metal reductase activity of triheme cytochrome C3
... Understand the mechanism of electron transfer of cytochromes with few hemes is the starting point for further studies with cytochromes with more heme groups, like[r] ...
Lepidopteran HMG-CoA reductase is a potential selective target for pest control
... HMG-CoA reductase (HMGR) revealed differences between lepidopteran pests and other organisms, which suggested insect HMGR could be a selective insecticide target ...
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and susceptibility for cervical lesions: a meta-analysis.
... drofolate reductase (‘‘MTHFR’’ or ‘‘methylenetetrahydrofolate reductase’’ or Methylenetetrahydrofolate Reductase AND (NADPH2)) with terms for genetic variations (‘‘polymorphism’’ or ‘‘variation’’ or ...
Activation of nitrate reductase of cashew leaf by exogenous nitrite
... Kaplan D, Mayer AM, Lips SH (1978) Nitrite activation of nitrate reductase in higher plants. Planta 138:205-209. Kaplan D, Mayer AM, Lips SH (1979) Effect of cyanide and nitrite on the activity of nitrate ...
Anaerobic bacteria: an investigation of metabolic important enzymes
... Sulphate reducing bacteria of the Desulfovibrio genus are able to use a large diversity of inorganic compounds as electron acceptors ( 1 ). Although considered for many years as strict anaerobes, several Desulfovibrio ...
Rev. bras. farmacogn. vol.27 número5
... Catharanthus roseus (L.) G. Don, Apocynaceae, is an immensely important medicinal plant, produces a variety of anticancerous compounds. The yield of two most investigated alkaloids vinblastine and vin- cristine is ...
Nitrite Biosensing via Selective Enzymes—A Long but Promising Route
... A novel nitrite biosensor based on conductometric electrode modified with cytochrome c nitrite reductase composite membrane. Optical biosensing of nitrite ions using cy[r] ...
Estudo do polimorfismo C677T do gene da metilenotetrahidrofolato redutase (MTHFR)...
... metilenetetrahidrofolate reductase (MTHFR - C677T and A1298C) have been described as having opposite effects on cancer patients, reducing cancer susceptibility and increasing drug-related toxicities, when ...
Aspectos moleculares de nitrato redutase da macroalga marinha Gracilaria tenuistipitata...
... Molecular Characterization of the assimilatory nitrate reductase gene and its daily expression in the marine red algae Gracilaria tenuistipitata (RHODOPHYTA). (em preparação)[r] ...
Prevalence of resistance associated polymorphisms in Plasmodium falciparum field isolates from southern Pakistan
... dihydrofolate reductase (pfdhfr A16V, N51I, C59R, S108N, I164L) and dihydropteroate synthetase (pfdhps A436S, G437A and E540K) genes and pfmdr1 gene copy numbers were determined using PCR based ...