Mitochondrial dysfunction
Top PDF Mitochondrial dysfunction:
Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin expressing cells Possible role of peroxisome proliferator activated receptor gamma (PPAR gamma) in the pathogenesis of Huntington disease
... drial dysfunction in mutant huntingtin-expressing cells chal- lenged with a calcium ...the mitochondrial potential loss, oxida- tive stress, and mitochondrial calcium deregulation in the thap- ...
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Melatonin in mitochondrial dysfunction and related disorders
... and Mitochondrial Dysfunction in ...of mitochondrial com- plex ...the mitochondrial dysfunction as major cause of the disease, with respiratory chain impairment relegated to a late ...
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Calcium Release from Intra Axonal Endoplasmic Reticulum Leads to Axon Degeneration through Mitochondrial Dysfunction
... et al., 2004; Fujimoto and Hayashi, 2011). It will be interesting to determine whether such MAMs are also present in the axonal do- main. Mutations in proteins responsible for maintaining the ER structure were ...
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TítuloiTRAQ based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis
... that mitochondrial dysfunction and disorganization of the cyto- skeleton were characteristic of the adipose tissue in ZMPSTE24 null mice, which mimic some but not all of the symptoms associated with ...
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Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease.
... Autophagy is a regulated lysosomal pathway involved in the degradation and recycling of cytoplasmic materials [38- 42]. During autophagy, cytoplasmic materials are seques- tered into double-membraned vesicles, ...
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Liver mitochondrial dysfunction is reverted by insulin like growth factor II (IGF II) in aging rats
... which mitochondrial dysfunction is one of the most relevant endpoint as an intracellular source of free radicals perpetuating oxidative cellular damage and causing ATP ...
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Melatonin and mitochondrial dysfunction in the central nervous system
... the mitochondrial dysfunction as major cause of the disease, impairment of ETC appears to be a late secondary event (Oliveira, ...defective mitochondrial calcium handling and impaired ATP ...with ...
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Amyloid B Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the AB peptide Implications for the pathogenesis of Alzheimer's disease
... Previous studies from our laboratory indicated that lithium protects hippocampal neurons against Ab pep- tide and Ab-AChE complex neurotoxicity [22,38]. Addi- tionally, we found that pre-incubation with Wnt-7a ligand ...
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Estrs oxidativo en la epilepsia resistente a frmacos
... ABSTRACT Pharmacoresistant epilepsy is a phenomenon increasingly affecting a substantial proportion of patients treated with current anti-epileptic drugs, who became refractive to therapy. Coincidently, anti-epileptic ...
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TítuloThe mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint
... mitochondrial dysfunction. Oligomy- cin is a specific inhibitor of mitochondrial complex V; however, a great number of findings suggest a role for impairment of other mitochondrial respiratory ...
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Canonical Wnt signaling protects hippocampal neurons from A beta oligomers: role of non canonical Wnt 5a/Ca2+ in mitochondrial dynamics
... of mitochondrial dynamics, preventing the changes induced by A β oligomers (A β o) in mitochondrial fission-fusion dynamics and modulates Bcl-2 increases induced by ...modulates mitochondrial ...
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Synthetic tambjamine analogues induce mitochondrial swelling and lysosomal dysfunction leading to autophagy blockade and necrotic cell death in lung cancer
... Nevertheless, mitochondrial dysfunction along with a defect in autophagy catabolism due to lysosomal deacidification might be detrimental to tumor cells since they produce low rates of ATP and impaired ...
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Low doses of insulin like growth factor I induce mitochondrial protection in aging rats
... the mitochondrial dysfunction associated with aging in this ex- perimental model in ...peroxidation, mitochondrial dysfunction, and depletion of ATP (13, 27, 30 ...with mitochondrial ...
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Trimetazidine prevents palmitate induced mitochondrial fission and dysfunction in cultured cardiomyocytes
... between mitochondrial dynamics, metabo- lism and cardiac mechanical efficiency has become an interesting subject of ...the mitochondrial fission protein DRP-1, and mitochondrial dysfunction in ...
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Diabetes and the brain: oxidative stress, inflammation, and autophagy
... Figure 1: Scheme summarizing the involvement of oxidative stress (mitochondrial dysfunction and ER stress), inflammation, and autophagy in the diabetic brain. GSH: reduced glutathione; GSSG: glutathione ...
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TítuloMitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts: a meta analysis and functional study
... Transmitochondrial cybrids are cell lines consisting of mito- chondria from different sources in a de fi ned and uniform nuclear background. They constitute an interesting model and allow the study of the real role of ...
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Modulation of mitochondrial Ca2+ uptake by estrogen receptor agonists and antagonists
... that mitochondrial ATP synthase binds estradiol conjugated to bovine serum albumin (Zheng & Ramirez, 1999a) and that several estrogens and polyphenolic phytochemicals inhibit mitochondrial ATP synthase ...
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Pathophysiological basis of albumin use in cirrhosis
... circulatory dysfunction in type-1 hepatore- nal syndrome is very fast, intense and frequently associated with failure in the function of other or- gans including the brain, adrenal glands, lungs, and ...
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CFTR activity and mitochondrial function
... the mitochondrial abnormalities found in CF cells or ...regulating mitochondrial functions, in particular de OXPHOS pathway, and the role of mitochondria in modulating the inflammatory process, and their ...
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EL TRATAMIENTO CON EL ANTICUERPO ANTI-PROTEOGLICANO CHP3R99 NO AFECTA LA BIOENERGÉTICA MITOCONDRIAL EN RATONES / The anti-proteoglycan antibody chP3R99 treatment does not affect mitochondrial bioenergetic in mice
... and mitochondrial redox status have not been studied ...liver mitochondrial function from C57BL6 mice subcutaneously treated with 50 µg of chP3R99 (weekly during 3 ...The mitochondrial NAD(P)H status ...
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