Mouse model
Physical Exercise and Mitochondrial Disease: Insights From a Mouse Model
... The promotion of mitochondrial biogenesis through either genetically or pharmacologically (bezafibrate administration) stimulation of PGC-1α, has been shown to increase OXPHOS capacity in cytochrome c oxidase-deficient ...
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Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1 Delta E9 mouse model of Alzheimer's disease
... transgenic mouse model, which coexpresses APPswe and the exon 9 deletion of the presenilin 1 (PSEN1) gene, was used to examine, in vivo, the effect of lithium and rosiglitazone on Ab ...
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Sheathless CE MS based metabolic profiling of kidney tissue section samples from a mouse model of Polycystic Kidney Disease
... Capillary electrophoresis-mass spectrometry (CE-MS) using a sheathless porous tip interface emerged as an attractive tool in metabolomics thanks to its numerous advantages. One of the main advantages compared to the ...
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Phenotype consequences of myophosphorylase dysfunction: insights from the McArdle mouse model
... although we measured the maximal endurance capacity of the mice and were able to document the marked exercise capacity limitation of the McArdle mice, we did not identify a unique feature of the disease in patients, that ...
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Low survival rate and muscle fiber-dependent aging effects in the McArdle disease mouse model
... Perinatal mortality. During the period from January 2013 to May 2018 a total of 139 matings of the McArdle mouse model colony were performed. From these, 19 were wild-type (WT) x heterozygous (HTZ), 47 HTZ ...
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Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease.
... Increased quantal content and strong synaptic depression We have found a gain-of-function phenotype in neurotransmit- ter release at the motor nerve terminals of R6/1 transgenic mice, a mouse model of ...
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Functional neuroimaging of amphetamine induced striatal neurotoxicity in the pleiotrophin knockout mouse model / M L Soto Montenegro [et al ]
... induced neurotoxicity are lacking. The aim of this study was to evaluate in vivo the changes in brain glucose metabolism caused by amphetamine in the pleiotrophin knockout mouse (PTN-/-), a genetic model ...
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Beneficial effect of fluoxetine and dertraline on chronic stress induced tumor crowth and cell dissemination in a mouse model of lymphoma : crucial role of antitumor immunity
... Clinical data and experimental studies have suggested a relationship between psycho- social factors and cancer prognosis. Both, stress effects on the immune system and on tumor biology were analyzed independently. ...
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PARP inhibition attenuates histopathological lesion in ischemia/reperfusion renal mouse model after cold prolonged ischemia.
... a model 2A S&T metallic clip (S&T Microlab AG, Rheinfall, Switzerland), maintaining the kidneys within the abdominal cavity under UW solution flow at 4 ∘ ...
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Smoking exacerbates amyloid pathology in a mouse model of Alzheimer's disease
... The effects of smoking on AD remain unclear. For many years, smoking was considered to be protective for the development of AD 6,7 . It was proposed that acute stimulation of neuronal nicotinic receptors may have ...
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Prenatal development of skull and brain in a mouse model of growth restriction
... E18.5 mouse faces tend to be projected and relatively larger in conigurations with larger brains, for very early prenatal stages Boughner and collabora- tors (2008) showed that more prognathic faces are ...
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Restoration of nNOS\03BC function in the MDX mouse model of Duchenne muscular distrophy
... from mouse skeletal muscle (mix of hind limb muscles) using the RNeasy Fibrous Tissue Mini Kit ...of mouse skeletal muscle using primers nnos5b and ...
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Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy
... Studies in brain cancer patients and rodent evidences that radiation-related neurofunctional sequelae are associated with a variety of anatomical changes that occur in the irradiated non-tumoral tissue (Makale et al., ...
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The urgent need to recover MHC class I in cancers for effective immunotherapy.
... transgenic mouse model based on the Trh4-specific CD8 + T cell clone, we observed an efficient thymic selection of these T cells, indicating that the TEIPP T cell repertoire is not affected by central ...
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Original Article Effects of brain-derived neurotrophic factor-pretreated neuron stem cell transplantation on Alzheimer’s disease model mice
... In this study, we tried to improve the traditional NSC transplantation methods to achieve a bet- ter effect. The AD mouse model was construct- ed and the brain-derived neurotrophic factor (BDNF) was used to ...
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DCE@urLAB: a dynamic contrast-enhanced MRI pharmacokinetic analysis tool for preclinical data
... cokinetic model) through the calculation of its jacobian ...Tofts model of the whole DCE dynamic slice (128 × 128 = 16384 pixels) and 40 dynamic frames, took about 5 minutes in the personal computer ...
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jhtp4_12.ppt
... right mouse button on a mouse with two or three ...one-button mouse, the user can press the Meta key on the keyboard and click the mouse ...
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Lauric acid is an inhibitor of Clostridium difficile growth in vitro and reduces inflammation in a mouse infection model
... approved by the IACUC of NCKU (approval NCKU-IACUC- 102-149) and the Biosafety and Radiation Safety Management Division of NCKU. The animal model of CDI was established as previously described (Chen et al., 2008; ...
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Homenaje biológico a Mickey Mouse
... En cualquier caso, los rasgos abstractos de la infancia humana producen en nosotros poderosas respuestas emocionales, incluso cuando aparecen en otros animales. Yo propongo que la ruta evolutiva de Mickey Mouse, ...
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Mitochondria and endocrine function of adipose tissue
... displayed increase insulin sensitivity and were resistant to high fat diet-induced obesity (42). Notably, white adipocytes from this mouse model had a significantly increased number of mitochondria were ...
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