p38 Mitogen-Activated Protein Kinases
Papel de las cascadas de las MAPKS (Mitogen Activated Protein Kinases) en la transducción de señales de estrés ambiental en macrófitos intermareales y árticos.
... Está ampliamente aceptado que las MAPKs constituyen el núcleo central de la red de señalización de estrés de las células animales, y más recientemente su estudio está siendo extendido a las plantas vasculares. Sin ...
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Mitogen activated protein kinases are involved in hepatocanalicular dysfunction and cholestasis induced by oxidative stress
... and p38 MAPK , and panspecific PKC inhibition with bisindolylmaleimide-1 (100 nM) or selective cPKC inhibition with Gö6976 (1 μM) prevented the latter two ...and p38 MAPK (SB203580) partially prevented ...
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Dual specificity phosphatase 1 expression inversely correlates with NF κB activity and expression in prostate cancer and promotes apoptosis through a p38 MAPK dependent mechanism
... the mitogen-activated protein kinases (MAPK) family (Dhillon et ...ular, p38 MAPK has been previously shown to be involved in prostate cancer cells, where it controls diverse cellular ...
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Modulation of interferon gamma induced glial cell activation by transforming growth factor beta 1: A role for STAT1 and MAPK pathways
... is activated by a Janus-activated kinase (JAK)-dependent phosphorylation on tyrosine Y701 (pSTAT1 tyr ) to translocate into the nucleus and induce gene expression (Platanias 2005; Gough et ...pathways ...
11
Novel indole based tambjamine analogues induce apoptotic lung cancer cell death through p38 mitogen activated protein kinase activation
... receptors, protein kinases, topoisomerases, to name a ...metabolism, protein kinases, transcription factors, cathepsins and heat shock proteins (Table ...
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Estudio de la nucleasa EndoG en el protozoo "Leishmania infantum": caracterización e implicaciones en la supervivencia y muerte del parásito
... Apoptosis, one of the most important mechanisms of pro- grammed cell death (PCD), is present in all multicellular organisms and participates in processes such as development, aging, immu- nity and tissue homeostasis ...
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Endoplasmic reticulum stress independent activation of unfolded protein response kinases by a small molecule ATP mimic
... is activated by binding directly to unfolded polypeptides (Credle et ...global protein synthesis is attenuated, while a few mRNAs, including that encoding the transcription factor ATF4, are preferentially ...
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Resistencia a la proteína C activada
... and activated protein C (APC)-resistant individuals dur- ing clotting: an insight into the APC-resis- tance ...(activated protein C ...
6
Estudi de la regulació transcripcional del gen de CD69
... Hypersensitive sites (HSs) are genomic regions that present increased sensitivity to cleavage by DNase I as a result of altered nuclesomal structure and commonly correspond to cis-acting regulatory elements (Gross and ...
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Interacción de los receptores dopaminérgicos D4 y opioides tipo [micra] en el estriado: implicación en la fase inicial del consumo de morfina
... Calmodulin-dependent protein kinase) fosforila a la proteína en el residuo serina 142 (Ser-142), promoviendo la disociación del dímero de CREB y reduciendo así la transcripción de genes mediada por este factor de ...
249
Estudi dels mecanismes moleculars implicats en l’associació entre inflamació i alteracions metabòliques en cèl∙lules cardíaques
... PGC-1a binds nuclear receptors through the leucine-rich LXXLL motifs designated L2 and L3, which are located within the N terminus of the coactivator. 24 In contrast, NF-kB requires the binding to specific LXXLL motifs ...
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Estudio de los mecanismos moleculares involucrados en las propiedades anticancerosas y antimetastásicas de las prodigininas. Identificación de mTOR como diana molecular en células de melanoma
... a protein kinase ubiquitously expressed within cells that regulates cell growth and survival by integrating nutrient and hormonal ...mTOR protein has been linked to development of cancer, raising mTOR as an ...
183
Abscisic Acid Supplementation Rescues High Fat Diet Induced Alterations in Hippocampal Inflammation and IRSs Expression
... In this study, we have made use of a well-established model of neuroinflammation – feeding rats a HFD for three months – to study its effects on the insulin-signalling pathway. In addition, we have evaluated the effects ...
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TítuloInfluence of ghrelin and growth hormone deficiency on AMP activated protein kinase and hypothalamic lipid metabolism
... metabolism, protein and activity levels of enzymes involved in the synthesis and oxidation of lipids were measured in wild-type Lewis rats ...SREBP1c protein levels in the hypothalamus ...
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Regulacin gnica apoptosis va p38 en procesos de neuroexcitotoxicidad
... the p38 pathway, in neurototoxicity; which could be associated with possible changes in the levels of expression of early genes correlationated with the apoptotic process of neuronal death; throughout the ...
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Cycling Dof Factors: Molecular and functional characterization of Arabidopsis thaliana AtCDF3 and tomato (Solanum lycopersicum L.) SlCDF3 in response to abiotic stress
... DOF protein has been identified in maize (ZmDOF1) and enhances transcription from C4 Phospho-Enol-Pyruvate Carboxylase (PEPC) promoter (Yanagisawa and Sheen, 1998; Yanagisawa, ...
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Sndrome de las plaquetas pegajosas en un paciente con isquemia cerebral transitoria y en sus familiares Informe de un caso
... III, protein C, protein S), scree- ning tests for antiphospholipid syndrome, DNA analysis of gene polymorphisms – factor V Leiden, factor II 20210A, glycoprotein III and aggregometry after stimulation with ...
6
Functional study of potential sHSPs in Arabidopsis and tomato under environmental stress
... an important role in the transcription initiation. Furthermore, numerous stress-related elements were located in the identified BDPs. The low responsive LTREATLTI78 and LTRECOREATCOR15 elements were predicted in the ...
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TítuloExpression of epicardial adipose tissue thermogenic genes in patients with reduced and preserved ejection fraction heart failure
... temperature for 20 min and then centrifuged at 1500 g for 10 min at 4ºC. In the hospital laboratory, fasting glucose, glycated hemoglobin (HbA1c), total cholesterol, low-density lipoprotein (LDL), high-density ...
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IP3 production in the hypersensitive response of lemon seedlings against Alternaria alternata involves active protein tyrosine kinases but not a G protein
... Protein kinases are also described as part of the signaling pathways that lead to the development of defensive responses in ...tyrosine kinases (Koch et ...the protein substrate(s) correspond ...
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