Rheumatoid Arthritis
Rheumatoid Arthritis Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: Shared Mechanistic and Phenotypic Traits Suggest Overlapping Disease Mechanisms
... with rheumatoid arthritis is approximately ...tomography. Rheumatoid arthritis-interstitial lung disease patients have three times the risk of death compared to those with rheumatoid ...
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TítuloEvaluation of 12 GWAS drawn SNPs as biomarkers of rheumatoid arthritis response to TNF inhibitors A potential SNP association with response to etanercept
... Research in rheumatoid arthritis (RA) is increasingly focused on the discovery of biomarkers that could enable personalized treatments. The genetic biomarkers associated with the response to TNF inhibitors ...
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ANTI-CITRULLINE ANTIBODIES IN THE DIAGNOSIS AND PROGNOSIS OF RHEUMATOID ARTHRITIS: Evolving Concepts
... Rheumatoid arthritis (RA) is a common autoimmune disease with a prevalence of up to 1% of the population worldwide. Patients with RA follow a variable disease course and have different prognoses with regard ...
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Practical Approach to the Evaluation and Management of Rheumatoid Arthritis Interstitial Lung Disease Based on its Proven and Hypothetical Mechanisms
... with rheumatoid arthritis varies from 10 to 42%. Rheumatoid arthritis patients with interstitial lung disease have three times the risk of death compared with those without the ...in ...
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TítuloValidation study of genetic biomarkers of response to TNF inhibitors in rheumatoid arthritis
... Genetic biomarkers are sought to personalize treatment of patients with rheumatoid arthritis (RA), given their variable response to TNF inhibitors (TNFi). However, no genetic biomaker is yet sufficiently ...
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TítuloIdentification of patients at risk of non adherence to oral antirheumatic drugs in rheumatoid arthritis using the Compliance Questionnaire in Rheumatology: an ARCO sub study
... Data from a systematic review of the impact of medication regimen factors on adherence to chronic treatment showed that in most of the therapeutic areas evaluated (with the exception of asthma/pulmonary disease), there ...
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Association of IL4Rsingle nucleotide polymorphisms with rheumatoid nodules in African Americans with rheumatoid arthritis
... The Consortium for the Longitudinal Evaluation of African-Americans with Early Rheumatoid Arthritis (CLEAR) includes the following investigators: Univer- sity of Alabama at Birmingham: S. Louis Bridges, ...
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Oxidative Stress in Patients with Rheumatoid Arthritis
... groups. Rheumatoid arthritis, despite being a disease predom- inantly of the joints, can have different clinical patterns with severe extra-articular involvement; it is consid- ered a systemic disease with ...
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TítuloSenescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype
... such as rheumatoid arthritis (RA). Epidemiology of RA shows that its incidence increases with aging, with the sharpest incidence rise between the fourth and sixth de- cades of life [16]. Aging of the T-cell ...
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Genomic approaches for the identi cation of risk loci for Rheumatoid Arthritis
... TNFα cytokine were detected in RA synovial biopsies, only small amounts of IL2 or IFNγ could be found. Recent findings, however, are broadening our vision on the CD4+ subtype paradigm. In 1995, Sakaguchi and colleagues ...
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Comparison of drug survival rates for tumor necrosis factor antagonists in rheumatoid arthritis.
... Patients whose records were incorrect were excluded from the study. Five patients had a diagnosis other than RA: three had juvenile idiopathic arthritis and two had ankylosing spondylitis. Any patient who died ...
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Psychological variables and physical exercise in patients with rheumatoid arthritis
... ARTRITE REUMATÓIDE E SAÚDE MENTAL Há mais de 100 anos que a AR figura como um desafio para profissionais da área da saúde, sendo que as formas de prevenção, tratamento e cura não estão totalmente estabelecidas e parecem ...
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TítuloCardiovascular disease in immune mediated inflammatory diseases: a cross sectional analysis of 6 cohorts
... as rheumatoid arthritis, systemic lupus erythema- tosus, psoriasis, psoriatic arthritis, and inflammatory bowel disease, are associated with higher rates of cardiovascular morbidity and mortality, ...
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TítuloAll trans retinoic acid inhibits migration and invasiveness of rheumatoid fibroblast like synoviocytes
... Fibroblast-like synoviocytes (FLSs) are pivotal in inflammation and joint damage of rheumatoid arthritis (RA). They acquire an active and aggressive phenotype, displaying increased migra- tion and ...
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Tristetraprolina Proteína reguladora del TNF-α de importancia patogénica en artritis reumatoide
... erosive arthritis, autoimmunity and myeloid ...with rheumatoid arthritis a low TTP/TNF- α gene expression ratio could indicate failure to produce adequate amounts of TTP in response to increased TNF- ...
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14,15 The diagnosis cannot be established by a single laboratory test or procedure but is aided by the use of seven diagnostic criteria
... with rheumatoid arthritis benefit from early 2nd line therapy: 5-year followup of a prospective double blind placebo con- trolled ...in rheumatoid ar- thritis: a 3 year followup on the Hydroxy- ...
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Posible papel de Porphyromonas gingivalis en el desarrollo de la artritis reumatoide
... Various studies have suggested a link between severe periodontitis, the prevalence of Porphyromonas gingivalis, and the development of rheumatoid arthritis. As evidence of this relationship, P. gingivalis ...
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Antibody profiles in patients treated with tumor necrosis factor-alpha antagonists: new findings
... of rheumatoid arthritis (RA) patients with anti-tumor necrosis factor-alpha (anti–TNF- ␣ ) biologic agents has been associated with a reduction in the levels of specific autoantibodies, such as ...
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Genetic basis of Sjögren's syndrome. How strong is the evidence?
... (secondary), of which the most frequent are Hashi- moto’s thyroiditis and rheumatoid arthritis (RA). The spectrum of the disease may extend from an organ specific autoimmune disorder (autoimmune exocrino- ...
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Asociación de los polimorfismos 89 G>A, 90 T>C y 92 G>C del gen PADI4 con anticuerpos contra péptidos citrulinados cíclicos (anti-CCP) en pacientes con artritis reumatoide del Sur de México
... Rheumatoid arthritis is characterized by persistent synovitis, systemic inflammation, and presence of autoantibodies. To date, we know that approximately 60% of the risk for developing RA is attributable to ...
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