Signalling pathways
The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice.
... whole-body impact on glucose homeostasis (see Fig. 8). However, additional extra-pancreatic effects of rimonabant on glucose homeostasis cannot be ruled out and those of rapamycin are evident. In fact, rapamycin at the ...
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Wnt signalling in neuronal differentiation and development
... secreted signalling molecules that activate signalling cascades involved in different aspects of embryonic develop- ment including cell fate specification, polarity and migration (Clevers and Nusse 2012; ...
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TítuloNotch signalling in cancer stem cells
... critical signalling pathways that govern stem cells such as Notch, Wnt, BMP (Bone Morphogenic Protein) and Hedgehog signalling pathways would allow stem cells to become independent of growth ...
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T CELL RECEPTOR SIGNALLING NETWORKS BRANCHED DIVERSIFIED AND BOUDEND
... CSK recruitment to the plasma membrane. We do not fully understand how CSK is normally recruited to the plasma membrane in T cells. Various transmembrane adaptor molecules with the potential to interact with Figure 1 | ...
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TítuloBiology of BMP signalling and cancer
... of signalling pathways involved in normal embryonic development and in tissue homeostasis in ...these signalling pathways are Wnt, Hedgehog, Notch and BMP ...BMP signalling as well as ...
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TítuloWnt signalling and cancer stem cells
... Wnt signalling pathways, such as with transcription factor 7-like 2 gene (TCF7L2), may impart increased risk for type 2 DM in some populations [106] as well as have increased association with obesity ...
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An update on sugar transport and signalling in grapevine
... Protein kinases are major components of intracellular signal transduction enabling plant cells to respond rapidly to envi- ronmental cues. VvSK1 was identified as a sugar- (and ABA-) inducible protein kinase affecting ...
12
TítuloHedgehog signalling as a target in cancer stem cells
... Hh signalling on fate and proliferative capacities of distinct sets of embryonic stem ...Hh signalling can regulate cell proliferation through the activation of the cell cycle regulatory proteins cyclin D ...
12
De novo assembly and functional annotation of Myrciaria dubia fruit transcriptome reveals multiple metabolic pathways for L-ascorbic acid biosynthesis
... metabolic pathways reconstructed from the annotated unigenes of ...KEGG pathways with the M. dubia transcriptome. The well represented pathways discovered in this study in- cluded L-ascorbic acid ...
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Pathways to citizenship: Generational reproduction of mother’s legal status
... complex pathways to citizenship, presenting the stories of several mothers and their mixed status families, their experiences and restrictions on access to citizenship ...research pathways that are being ...
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Signaling pathways involved in colorectal cancer progression
... The first report on the crosstalk between Wnt and Notch signaling was reported in fruit fly which showed NICD can bind to disheveled one and the subsequent Notch signaling and regulate the Wnt pathway. Wnt/β-catenin ...
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Complex fluctuations and robustness in stylized signalling networks
... simple signalling units. We analyse networks of simple signalling units where the type of scaling of the fluctuations is associated with (i) a complex topology with a discrete and sparse number of random ...
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TítuloRelevant networks involving the p53 signalling pathway in renal cell carcinoma
... critical pathways and interactions associated with alterations in renal function and renal tumour properties is ...among pathways. Regulation of metabolic pathways is an important role of ...
10
Ecosystem impacts of hypoxia: thresholds of hypoxia and pathways to recovery
... Coastal hypoxia is increasing in the global coastal zone, where it is recognized as a major threat to biota. Managerial efforts to prevent hypoxia and achieve recovery of ecosystems already affected by hypoxia are ...
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Integration of local and systemic signaling pathways for plant N responses
... tissues and plant organs. An illustrative example of both local and systemic regulatory pathways at work can be found in the nitrate modulation of root system architec- ture (RSA). A local supply of nitrate ...
7
A Longitudinal Examination of Different Etiological Pathways to Alcohol Use and Misuse
... etiological pathways involved in different alcohol consumption patterns and alcohol misuse could help to develop more reliable and efficient prevention and treatment programs (Conrod et ...3 pathways in which ...
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SPECIALIZATION AUDITORY PATHWAYS IN THE MOLE
... To get morphological substrates for sensory specialization in the subterranean mammals, we investigate both auditory and visual pathways in the mole. The inferior colliculus (IC), an auditory relay, projects not ...
6
TítuloBacterial consortia utilizaing volatile organic compounds: mapping genomic determinants of essential biodegradation pathways
... whole pathways of VOC consumption by polymerase chain reaction ...lower pathways are virtually identical in either degrading microorganisms (Amann et ...
7
Hepatitis B virus and Hepatocarcinogenesis
... HBV DNA integration into the cellular genes is frequent- ly detected in HBV positive HCC. This viral integration leads to target gene transcription. Analysis of HBV DNA site in liver cancer enabled researchers to ...
5
Effects of AMP activated kinase modulators on intracellular Ca2+ signalling and C elegans lifespan
... However, several authors have recently tried to test this theory directly, studying the effect of oxidative damage and antioxidants on aging and half-life in several animal species, and the results have been negative ...
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