T cell
A stochastic T cell response criterion
... different cell types to provide fast and coordinated responses, characterized by recognition of pathogenic challenge, extensive cellular prolifer- ation and differentiation, as well as ...death. T cells are ...
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Differential role of SLP-76 domains in T cell development and function
... peripheral T cells (8, 9). SLP-76 plays an important role in T cell receptor signal transduction and T cell ...human T cell line (Jurkat) results in marked augmentation of ...
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Trypanosoma cruzi Experimental Infection Impacts on the Thymic Regulatory T Cell Compartment
... regulatory T cells in the course of Trypanosoma cruzi infection is still ...murine T . cruzi infection results in an impaired peripheral CD4 + Foxp3 + T cell differentiation due to the ...
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Receptor pre-clustering and T cell responses: insights into molecular mechanisms
... We implement these reactions as a Markov process, and solve them numerically using the standard Gillespie algorithm (49), and with the parameters summarized in Table 1. We have made use of three different ligands: 4A, ...
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T CELL RECEPTOR SIGNALLING NETWORKS BRANCHED DIVERSIFIED AND BOUDEND
... Classically, T cell signalling is described as going down from the TCR, via LAT, to activate the transcription fac tors that are required for T cell proliferation and for the differentiation ...
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T CELL TOLERANCE AND MULTIFUNTIONAL ROLE OF il-2R
... cells. T-cell growth, optimal induction of IL-2- dependent effector molecules, such as perforin and granzyme B, and terminal differentiation of CD8 + Teff cells all depend on high IL-2R signaling (54, 92, ...
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Solving constrained optimization using a T-Cell artificial immune system
... The main motivation of the work presented in this paper is to explore the capabilities of a new AIS model in the context of constrained global optimization. The proposed model is based on the process that suffers the ...
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T cell exhaustion process during chronic infection caused by intracellular trypanosomatids
... different T-cell popula- tions during the course of Leishmania and ...the T cells, achieving a less exhausted immune response and a great- er propensity to optimal control of the ...+ T ...
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Telaprevir may induce adverse cutaneous reactions by a T cell immune mediated mechanism
... The HCV protease inhibitor telaprevir associated with peginterferon–alpha and ribavirin, was widely used in the recent past as standard treatment in HCV genotype-1 infected patients. Telaprevir improves the sus- tained ...
5
NADþ protects against EAE by regulating CD4þ T cell differentiation
... þ cell development remain ...importantly, T-bet and GATA3, two transcription factors that regulate CD4 þ T cell Th1/Th2 fate decision were downregulated by NAD þ , whereas Foxp3, the master ...
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Hepatitis C virus strategies to evade the specific T cell response: a possible mission favoring its persistence
... CD8+ T cells in the context of HLA class II and HLA class I, ...helper T cells activate both CD8+ T cells and B cells through production of Th1 (IFN-γ IL-2) and Th2 (IL-4, IL-5, IL-6) cytokines, ...
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Desialylation of T lymphocytes overcomes the monocyte dependency of pokeweed mitogen induced T cell activation
... mouse T-cell from different donors are ...vated T cells ( 0·5 × 105/round-bottomed well ) generated by stimulation PNA failed to induce HA–IL-2 binding capacity in BDMC, of Nase-treated purified ...
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Class modeling analysis reveals T cell homeostasis disturbances involved in loss of immune control in elite controllers
... Despite the persistent control of HIV replication to un- detectable levels, several alterations related to a state of sys- temic inflammation have been recognized in ECs compared to seronegative subjects and to HIV ...
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Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity
... define T cell subset differentiation and the nature of effector adaptive immunity, the complexity of DC function is underscored by the existence of at least 2 DC subsets, with distinctive functional ...
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T Cell Based Immunosuppressive Therapy Inhibits the Development of Natural Antibodies in Infant Baboons
... is T-cell ...⫹ T cells in ␣ 1,3-galactosyltransferase gene-knockout mice, anti-Gal IgM increased significantly, indicating that the natural devel- opment of Abs was not inhibited by the absence of ...
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Angioimmunoblastic T Cell lymphoma: a diagnostic challenge
... Angioimmunoblastic T-cell lymphoma (AITL) accounts for 15–20% of all peripheral T-cell ...CD4 T-cell peripheral lymphoma that affects aged in- dividuals, causing B symptoms, ...
5
CD50 (Intercellular Adhesion Molecule 3) Stimulation induces calcium mobilization and tyrmine phosphorylation through p59b and p56 in jurkat T cell line
... To characterize the role of CD50 in leukocyte interactions, the different molecular events induced after cross-linking of CDS0 on T cell-derived Jurkat cell line have been analyzed.. [r] ...
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Fate of a naive T cell: a stochastic journey
... of T cell populations depends on migration, division and death of individual cells ...(1). T cells migrate between spatial compartments (spleen, lymph nodes, lung, liver, ...fluorescence-activated ...
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Retinoic acid as a modulator of T cell immunity
... on T cells were discovered few years ...instruct T cells to migrate to different ...+ T cells ...+ T cells [27] (Figure 1), CD8 + T cells [28] and IgA-secreting B cells ...on T ...
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Functional Diversity of T-Cell Subpopulations in Subacute and Chronic Hypersensitivity Pneumonitis
... of T cells in chronic HP is the principal reason for the inability of the host to eliminate the persisting ...of T-cell exhaustion in chronic lymphocyte choriomeningitis virus (LCMV), which ends in a ...
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