T-CELLS

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Targetless T cells in cancer immunotherapy.

Targetless T cells in cancer immunotherapy.

... activate T cell mediated anti-tumor ...regulating T-cell cytotoxicity has achieved impressive clinical responses, as has adoptive cell transfer (ACT) using expanded tumor infiltrating lymphocytes (TIL) or ...

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Virulent Salmonella Enterica Serovar Typhimurium Evades Adaptive Immunity by Preventing Dendritic Cells From Activating T Cells

Virulent Salmonella Enterica Serovar Typhimurium Evades Adaptive Immunity by Preventing Dendritic Cells From Activating T Cells

... and T cells were evalu- ated at day 5 ...by T cells specific for OVA- or flagellin-derived peptides could only be measured in mice challenged with ⌬ SPI-2, ⌬ SpiA, or ⌬ SpiC mutant Sal- ...

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Statins increase the frequency of circulating CD4+ FOXP3+ regulatory T cells in healthy individuals

Statins increase the frequency of circulating CD4+ FOXP3+ regulatory T cells in healthy individuals

... Statins have been shown to modulate the number and the suppressive function of CD4 + FOXP3 + T cells (Treg) in inlammatory conditions. However, it is not well established whether statin could also afect ...

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Interacciones entre los linfocitos T y el microambiente de la metástasis ósea de cáncer de mamaInteractions between T cells and the microenvironment of bone metastases of breast cancer

Interacciones entre los linfocitos T y el microambiente de la metástasis ósea de cáncer de mamaInteractions between T cells and the microenvironment of bone metastases of breast cancer

... of T cells against cancer cells. However it is known that T lymphocytes have osteoclastogenic activity in rheumatoid arthritis, which could increase the development of bone metastases, and ...

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Integrin avB3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells

Integrin avB3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells

... and T-cell acute lymphoblastic leukemia cells, in the later through a mammalian target of rapamycin–dependent reg- ulation of cell-cycle ...Malignant T cells produce and express VEGF ...

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3BP2 Deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation

3BP2 Deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation

... results in protein tyrosine phosphorylation that includes phos- phorylation of ZAP-70, Vav, and PLC- ␥ 1. Total protein ty- rosine phosphorylation and phosphorylation of ZAP-70, Vav, and PLC- ␥ 1 were normal in 3BP2 ⫺/⫺ ...

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Short Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control

Short Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control

... The study of mechanisms involved in resistance to HIV-1 infection or to AIDS progression is important to clarify viral pathogenesis to facilitate the development of new immunological therapies. Here, we evaluated the ...

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Carbon monoxide decreases endosome lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells

Carbon monoxide decreases endosome lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells

... + T cells in response to soluble antigens, both OVA and the Ag85B antigen from Mycobacterium tuberculosis ...to T cells when DCs were loaded either with antigens as large particles or small ...

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Caracterización del efecto de linfocitos T de metástasis ósea en la formación de osteoclastosCharacterization of the effect of bone metastasis T cells in osteoclast formation

Caracterización del efecto de linfocitos T de metástasis ósea en la formación de osteoclastosCharacterization of the effect of bone metastasis T cells in osteoclast formation

... and T cells can increase osteoclast formation and bone ...of T cells on the formation of osteoclasts in vivo and in ...of T cells on osteoclasts in vivo, Balb/C mice were ...

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Assessment of intrahepatic regulatory T cells in children with autoimmune hepatitis

Assessment of intrahepatic regulatory T cells in children with autoimmune hepatitis

... Background. T-cell populations regulate the balance of immune ...regulatory T cells (Tregs) are crucial for maintaining negative control of various immune ...different T-cell subpopulations ...

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Determinants of differential functions of galectin 8 on T cells and tumoral cells : interplay of galectin 8 isoforms, integrin and growth factor signaling pathways

Determinants of differential functions of galectin 8 on T cells and tumoral cells : interplay of galectin 8 isoforms, integrin and growth factor signaling pathways

... in cells as distinct as smooth muscle, rheumatoid synovial, endothelial and T cells (Arencibia et ...re-stimulated T cells (van den Brink et ...Jurkat T cells that Gal-8S ...

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Human metapneumovirus keeps dendritic cells from priming antigen specific naive T cells

Human metapneumovirus keeps dendritic cells from priming antigen specific naive T cells

... specifically, T-cell ...superantigen-induced T-cell activation by infect- ing conventional dendritic cells ...+ T cells (OT-II), which not only display reduced pro- liferation, but also ...

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Regulatory T cells but not NKT I cells are modulated by a single low dose cyclophosphamide in a B cell lymphoma tumor model

Regulatory T cells but not NKT I cells are modulated by a single low dose cyclophosphamide in a B cell lymphoma tumor model

... of T regulatory (Treg) and natural killer T (NKT) I cells, two cell populations of the innate immune response with opposing effects on the tumors, in a rat B cell lymphoma ...of T regulatory ...

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Thyroid hormones induce doxorubicin chemosensitivity through enzymes involved in chemotherapy metabolism in lymphoma T cells

Thyroid hormones induce doxorubicin chemosensitivity through enzymes involved in chemotherapy metabolism in lymphoma T cells

... In this work, in addition to THs involvement in CYP3A4 expression and activation, we also demonstrate a THs role in response to chemotherapeutic drugs. Both Doxo and VCR are metabolized by enzymes of the CYP3A family, ...

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MOLECULAR MECHANISMS OR T CELLS COSTIMULAION AND COINHIBITION

MOLECULAR MECHANISMS OR T CELLS COSTIMULAION AND COINHIBITION

... to T Con cells and positive signals to T Reg ...on T Con cells, but on T Reg cells it can interact with B and T lymphocyte attenuator (BTLA) or CD160 to deliver ...

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Profound CD4+ T lymphocytopenia in human immunodeficiency virus negative individuals, improved with anti human herpes virus treatment

Profound CD4+ T lymphocytopenia in human immunodeficiency virus negative individuals, improved with anti human herpes virus treatment

... CD4+ T lymphocytopenia with clinical immunodeficiency and opportunistic infections in per- sons without immunodeficiency history and no other cause of ...CD4+ T lymphocytopenia with treatment of chronic ...

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TH17 CELLS IN AUTOIMMUNE AND INFECTIOUS DISEASES

TH17 CELLS IN AUTOIMMUNE AND INFECTIOUS DISEASES

... CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed ...IL-17-producing T cells uncovered a new subset of Th cells designated Th17 ...

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Tolerancia inmunológica y trasplante renal

Tolerancia inmunológica y trasplante renal

... 31. Lopez M, Clarkson MR, Albin M, Sayegh MH, Najafian N. A novel mechanism of action for anti-thymocyte globulin: induction of CD4 CD25 Foxp3 regulatory T cells. J Am Soc Nephrol 2006;17:2844-53. 32. ...

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Assessment of allergen specific response in humans

Assessment of allergen specific response in humans

... of T-cells specific for minimally-cross- reactive epitopes did not cross-recognize the Phl p 1 derived epitopes in the corresponding ...of T cells, capable of cross-recognizing these epitopes ...

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T helper cells plasticity in inflammation

T helper cells plasticity in inflammation

... CD41 T cells can be subdivided from a functional point of view into two main subsets: effector cells, which provide protection against exogenous offending agents, and regula- tory T (Treg) ...

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