Tyrosine kinase
Role of Fms like tyrosine kinase 3 ligand as a potential biologic marker of lymphoma in primary Sjögren's syndrome
... Fms-like tyrosine kinase 3 ligand (Flt-3L) and lymphoma development in patients with primary Sjögren’s syndrome (pSS) from the French Assessment of Systemic Signs and Evolution of Sjögren’s Syndrome ...
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Astemizole, an Inhibitor of Ether Go Go 1 Potassium Channel, Increases the Activity of the Tyrosine Kinase Inhibitor Gefitinib in Breast Cancer Cells
... Background: Expression and activity of the potassium channel ether-à-go-go-1 (EAG1) are strongly related to carcinogenesis and tumor progression, which can be exploited for therapeutic purposes. EAG1 activity may be ...
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TítuloTyrosine kinase inhibitors reprogramming immunity in renal cell carcinoma: rethinking cancer immunotherapy
... that tyrosine kinase inhibitors (TKIs) modulate hematopoiesis and immune functions [9], and their effect on myelopoiesis depends on their different selectivity for c-kit and FLT3 receptors, expressed on ...
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Perfil mutacional por secuenciacin de nueva generacin en cncer de pulmn de clulas no pequeas en poblacin mexicana
... The clinical-pathological characteristics of the patients are the following: female gender in 76.7% of the cases, median age of 64.5 years with a range of 33-81 years, and 66.7% of 60 years or older (table I). Smokers ...
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2019.04.02.3
... Lymphoma Kinase (ALK) inhibitor is given orally in the treatment of non-small cell lung cancer ...Protein-Tyrosine Kinase, Tropomyosin receptor kinase B and Aurora kinase B having ...
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Commuting within the cell mind the GAPs Workshop on Systems Dynamics of Intracellular Communication: overcoming Distance in Signalling Networks
... body, various growth factors, such as NGF and EGF, trigger the activation of the MAPK pathway. After the activation of TrkA (shown in blue) several positive feedback loops induce persistent MAPK signalling, causing cell ...
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Glypican 1 regulates myoblast response to HGF via Met in a lipid raft dependent mechanism: Effect on migration of skeletal muscle precursor cells
... threonine kinase transforming growth factor β [65] and tyrosine kinase epidermal growth factor receptors, which are activated in lipid rafts, but rapidly relocalized to non– lipid rafts to ...
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Leucemia mieloblstica aguda: una perspectiva
... FLT3 kinase in experimental tumor xenograft models of human acute myelogenous ...receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase ...VEGFR-2 tyrosine ...
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UTP Controls Cell Surface Distribution and Vasomotor Activity of the Human P2Y(2) Receptor through an Epidermal Growth Factor Receptor transregulated Mechanism
... triggering tyrosine kinase activity that results in the activation of several signaling proteins, such Ras, phosphatidylinositol 3-kinase, and phospholipase C ␥ pathways, leading to mitogenic events ...
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her2 hyper-activation through the production of carboxy-terminal fragments
... therefore, tyrosine kinase activity ...HER2 tyrosine kinase mutation have been reported in lung cancer [54, 61] and a very recent multicenter study showed that mutated HER2 is a driver in 2% ...
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Osteonecrosis of the jaw in the era of targeted therapy and immunotherapy in oncology
... VEGF is an endothelial cell-specific mitogen in vitro and an angiogenic inducer in vivo. Its action is mediated by inter- action with two high affinity receptors, VEGFR-1 (tyrosine kinase Flt-1) and VEGFR-2 ...
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Metstasis cutneas de carcinoma renal de clulas claras
... case report and review of the literature. Emerging role of tyrosine kinase inhibitors in the treatment of advanced renal cell cancer: a review. Ann Oncol [Revista en línea]. Saeed S, K[r] ...
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Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation
... selective tyrosine kinase inhibitor ration- ally designed as a substitute for Imatinib (Gleevec/STI- 571®; Novartis) to overcome resistance and intolerance in patients with chronic myelogenous leukemia ...
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Umbilical cord blood transplantation from unrelated donors in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.
... Post-transplant tyrosine kinase inhibitor therapy The characteristics of the 19 patients who received TKI therapy after UCBT are summarized in Table ...
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IP3 production in the hypersensitive response of lemon seedlings against Alternaria alternata involves active protein tyrosine kinases but not a G protein
... Protein kinases are also described as part of the signaling pathways that lead to the development of defensive responses in plants. DHMC has been described as a competitive inhibitor of the peptide substrate of ...
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Clinicopathologic features of dual chronic hepatitis B and C infection: A comparison with single hepatitis B, C and delta infections
... signal-regulated kinase; MEK, extracellular signal-regulated kinase; HBV, hepatitis B virus; HCV, hepatitis C virus; TKRs, tyrosine kinase receptors; GEFs, guanine nucleotide exchange factors; ...
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TítuloNew insights into molecular mechanisms of sunitinib associated side effects
... FMS-like tyrosine kinase 3 (FLT3); colony-stimulating factor 1 receptor (CSF-1R); and glial cell line–derived neurotrophic factor receptor [RE arranged during transfection (RET); ...
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Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition
... ATM kinase assays were conducted using the protocol described by Sarkaria et ...with kinase buffer (10 mM HEPES pH = ...NaCl). Kinase reactions were initiated with the addition of an equal volume of ...
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Regulation of Placental Leptin Expression by Cyclic Adenosine 5 '-Monophosphate Involves Cross Talk between Protein Kinase A and Mitogen-Activated Protein Kinase Signaling Pathways
... The cAMP/PKA pathway and the MAPK cascades mod- ulate common processes in the cell and multiple levels of cross talk between these signaling pathways have been de- scribed (85– 88). In some cell types, and under certain ...
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