... for methylation (n = 44) and gene expression analysis (n = 36) were collected at the time of primary surgery and banked at ...a breastcancer pathologist and microdissected to obtain ...
... Breastcancer is the most frequently diagnosed cancer and the leading cause ofcancer death among females worldwide, with an estimated ...deaths in 2012, It alone ...
... to the other cell lines. Re-expression of claudin 1 protein on the surface of treated HCC1569 and MDA‑MB‑453 cells was confirmed by flow ...increase in claudin 1 signal in both ...
... Brain metastasisofbreastcancer is an important clinical problem, with few therapeutic options and a poor ...(MLK3) in controlling thein vitro migratory capacity ...
... levels of ICAM-1 inbreast tumors are associated with a more aggressive phenotype [30], and by studies highlighting the importance of vascular cell adhesion molecules in ...
... staging of patients with early-stage breastcancer is essential inthe treatment ...times in association with fine-needle aspiration biopsy or core needle ...However, the ...
... Background: Breastcancer is the most common malignant neoplasm inthe female ...for metastasis, and can show up many years after initial diagnosis and treatment of ...
... Thebreast tumor was classified as clinical stage IV, with metastasis to the lungs (lymphangitis carcinomatosa identified on CT) and bones, and surgery for thebreast lesion was ...
... characterization of crucial gene target(s) that will allow focused therapeutics development remains a ...interrogated the putative therapeutic targets associated with the transcription factor Grainy ...
... but the last is preferred by breast tumor ...involved in cell adhesion and proteolysis, causing metastasis, such as ADAMs, a family of multi-domain and multi-functional proteins that ...
... Loss of Rb expression promotes metastatic behavior in human breastcancer cell ...quantification of mammosphere-forming potency of MCF7ras and T47D cells with Rb ...Morphology ...
... examination ofthe tumor revealed an undifferentiated carcinoma (T3N0Mx). The lack of dysplasia and atypia ofthe intestinal epithelium and the normal glands surrounding ...
... expression of CDKN2A and MTAP; however. the MTAP promoter was partially ...deletion of CDKN2A in this cell line but not a deletion of CDKN2B or INK4A genes, which are closely located on ...
... purpose of this study was to develop quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for the analysis of proteins involved inmetastasisof ...
... function of Rrp1b and its exact role inmetastasis remain unclear at this ...regulator of Rap1 by serving as a GAP for Rap1 ...implicated in maintaining the integrity of ...
... overt metastasis remains largely unknown, in large part due to the lack of appropriate animal models that closely reca- pitulate the ...mimic the activation of indolent ...
... xenograft, breastcancer development has shown a low success rate in most trials due to the technically limited occurrence of mammary glands in neonatal ...inoculation of ...
... with the advent of high-throughput technolo- gies, gene expression profiling has enabled a more com- prehensive view ofthe molecular identity ofbreast ...6–8]. Breast ...
... define breastcancermetastasis ...performed in this report provide a comprehensive view of changes in gene expression elicited by over-expression of WNT5A in ...