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[PDF] Top 20 Design and Synthesis of Pironetin Analogue/Combretastatin A 4 Hybrids and Evaluation of Their Cytotoxic Activity

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Design and Synthesis of Pironetin Analogue/Combretastatin A 4 Hybrids and Evaluation of Their Cytotoxic Activity

Design and Synthesis of Pironetin Analogue/Combretastatin A 4 Hybrids and Evaluation of Their Cytotoxic Activity

... measurement of the cytotoxicity of the synthetic combretastatin A-4 derivatives 1-4 and their enantiomers, 5-8, 9a-12a and ...9b-12b. Pironetin analogues 14, ... See full document

18

Design and synthesis of pironetin analogue/combretastatin A 4 hybrids containing a 1,2,3 triazole ring and evaluation of their cytotoxic activity

Design and synthesis of pironetin analogue/combretastatin A 4 hybrids containing a 1,2,3 triazole ring and evaluation of their cytotoxic activity

... cause of death in developed countries [1], may be induced by a plethora of both external and internal factors, including genetic ...number of types of therapeutic attack has been ... See full document

9

Design and Synthesis of Pironetin Analogue/Colchicine Hybrids and Study of Their Cytotoxic Activity and Mechanisms of Interaction with Tubulin

Design and Synthesis of Pironetin Analogue/Colchicine Hybrids and Study of Their Cytotoxic Activity and Mechanisms of Interaction with Tubulin

... one of the few members of the group of TBMs that interacts with α -tubulin; thus, it is an interesting target from the pharmacological point of ...total synthesis of this natural ... See full document

14

Review and Analysis of mHealth Applications : Development and Evaluation of a Heart Diseases Self-Management App

Review and Analysis of mHealth Applications : Development and Evaluation of a Heart Diseases Self-Management App

... creation of the Internet, its massive use, especially in developed countries, has generated new forms of technology in almost every aspect of life ...One of these aspects is health care; ... See full document

177

Amidinate Aluminium Complexes as Catalysts for Carbon Dioxide Fixation into Cyclic Carbonates

Amidinate Aluminium Complexes as Catalysts for Carbon Dioxide Fixation into Cyclic Carbonates

... change of cocatalyst from tetrabutylam- monium bromide to tetrabutylammonium iodide has a positive effect for each of complexes 1–6, the conversion of styrene oxide 7a into styrene carbonate 8a was ... See full document

7

Combined household water treatment and indoor air pollution projects

Combined household water treatment and indoor air pollution projects

... 4. SYNTHESIS OF EXPERIENCE FROM CAMEROON AND KENYA ...[r] ... See full document

80

Antiplasmodial and Cytotoxic Activity of Piper Piedecuestanum Trel  and Yunck

Antiplasmodial and Cytotoxic Activity of Piper Piedecuestanum Trel and Yunck

... species of Piper are economically important, among them Piper nigrum from which the pepper is obtained, condiment popularly used all over the ...range of traditional foods has been reported in the treatment ... See full document

9

Steroid saponins and other constituents from the rhizome of Trillium tschonoskii Maxim and their cytotoxic activity

Steroid saponins and other constituents from the rhizome of Trillium tschonoskii Maxim and their cytotoxic activity

... 1702 ISSN 0326-2383 KEY WORDS: Cytotoxicity, GC-MS, Steroid saponin, Trillium tschonoskii Maxim.. *Author to whom correspondence should be addressed.[r] ... See full document

1

Green synthesis of polysaccharides based gold and silver nanoparticles and their promissory biological activity

Green synthesis of polysaccharides based gold and silver nanoparticles and their promissory biological activity

... reduction of silver ions through the regeneration of alginic acid (Alg) from sodium ...the synthesis of Ag NPs using sodium citrate in order to compare (polysaccharides) in the morphology ... See full document

9

Development of Efficient Techniques for the Analysis and Design of Antennas in Dual-Reflectarray Configuration

Development of Efficient Techniques for the Analysis and Design of Antennas in Dual-Reflectarray Configuration

... is their narrow frequency band operation, produced by the bandwidth of the printed elements and by the differential spatial phase delay ...bandwidth of the element, which is the most ... See full document

243

Cincuenta años con la piedra de la locura : apuntes autobiográficos de un científico argentino

Cincuenta años con la piedra de la locura : apuntes autobiográficos de un científico argentino

... del sueño y demencia. Todos los pacientes recibieron 3 mg de melatonina en cápsulas de gelatina por vía oral 30 min antes de acostarse, durante 21 días. La calidad del sueño y el alerta durante el día fueron evaluados ... See full document

252

Desarrollo de dos nuevas sondas fluorogénicas derivadas de la bis-vainillina para la detección de catiónes metalicos trivalentes

Desarrollo de dos nuevas sondas fluorogénicas derivadas de la bis-vainillina para la detección de catiónes metalicos trivalentes

... derivatives of bis-vainilline that contain semicarbazide or hydrazines can act as sensors of ...3- and 3’- with hydrazoline and isoniazide, using fluorescence as analytical signal for ... See full document

5

(BIo)analytical microsystems based on the use of nanoparticles. Microreactors for the synthesis of nanoparticles

(BIo)analytical microsystems based on the use of nanoparticles. Microreactors for the synthesis of nanoparticles

... most of the synthetic approaches for the synthesis of gold nanoparticles with alkanethiols as stabilizer take as reference this ...mixture of hydrogen tetrachloroaurate in water with ... See full document

329

Cytotoxic, antiangiogenic and antitelomerase activity of glucosyl  and acyl  resveratrol prodrugs and resveratrol sulfate metabolites

Cytotoxic, antiangiogenic and antitelomerase activity of glucosyl and acyl resveratrol prodrugs and resveratrol sulfate metabolites

... 2 and 3 and show that treatment of HT-29 cells with resveratrol and the aforementioned derivatives leads in fact to various degrees of reduction in the transcription of hTERT ... See full document

23

Síntesis y evaluación de los ésteres de doble acción del ketorolaco y de la aspirina

Síntesis y evaluación de los ésteres de doble acción del ketorolaco y de la aspirina

... Solution of the derivative (4a) (1 mg/ml) was maintained at 37 + ...intervals and after bringing the pH to acidic side (~2), the acidified aliquots were extracted into isopropyl ether so that the released ... See full document

19

Synthesis and conformational analysis of leptocarpin derivatives  Influence of modification of the oxirane ringon leptocarpin's cytotoxic activity

Synthesis and conformational analysis of leptocarpin derivatives Influence of modification of the oxirane ringon leptocarpin's cytotoxic activity

... transformation of Leptocarpin was obtained through the acid treatment of the leptocarpin with saturated chloroformic solution with HCl, to mimick what would happen when the drug encounters the gastric acid ... See full document

15

Design and synthesis of simplified sordaricin derivatives as inhibitors of fungal protein synthesis

Design and synthesis of simplified sordaricin derivatives as inhibitors of fungal protein synthesis

... Keywords: antibiotics; enzyme inhibitors; fungi; molecular modeling~mechanics Sordadn la is an antifungal mould metabollte isolated from Sordaria araneosa, t Derivatives of sordarin la a[r] ... See full document

6

Synthesis of biodegradable microspheres of tramadol by simple phase separation technique and their in vitro evaluation

Synthesis of biodegradable microspheres of tramadol by simple phase separation technique and their in vitro evaluation

... Simple phase separation method was adopted to prepare microspheres; Dichloromethane (DCM) and Liquid Paraffin (LP) were employed as solvent and non-solvent respectively.. Five kinetic mo[r] ... See full document

1

Synthesis and cytotoxic activity of tri acyl ester derivatives of uridine in breast cancer cells

Synthesis and cytotoxic activity of tri acyl ester derivatives of uridine in breast cancer cells

... concentrations of 1, 10 and 100 µM of uridine or derivatives, were incubated for 48 hours at 37°C for 48 ...µL of MTT (5 mg/ mL, Sigma) were added, and the plates were incubated in ... See full document

9

Design, Synthesis and molecular docking study of hybrids of quinazolin 4(3H) one as anticancer agents

Design, Synthesis and molecular docking study of hybrids of quinazolin 4(3H) one as anticancer agents

... series of N-(2-(4-fluoro phenyl)-4-oxothiazolidin-3-yl)-4-(4-oxo-2-[(4-substituted phenyl)-quinazolin-3(4H)-yl)] benzamide derivatives were successfully synthesized and ... See full document

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