[PDF] Top 20 Exosomal microRNAs in colorectal cancer

... participate in almost every cellular process includ- ing apoptosis, proliferation and differentiation ...[15]. In fact single miRNAs may regulate multiple target genes acting as a master control of gene ... See full document

... found in prostasomes isolated from human semen, such as prostatic acid phosphatase (PAP), PSA, prostate-specific transglutaminase and prostate stem cell antigen (PSCA) which are also markers for prostate ... See full document

... progress in the knowledge of the altered signal- ing routes in colorectal cancer (CRC), laid the founda- tions for the application of therapies with specific tar- ...mutations in the ... See full document

... role in the regulation of cellular protein levels during cell ...interest in studying them in several ...proteins) in cell-to-cell communication within the same tissue (autocrine signaling) or ... See full document

... and colorectal) cancer is one of most diagnosed and, together with breast and lung tumours, is responsible for most ...advances in the understanding of the molecular causes of this disease, there is ... See full document

... role in the ultimate development of ...culminate in cancer via several mechanisms, and miRNAs have been shown to influence a number of these ...increased in CRC associated with colitis, while ... See full document

... Features of the 196 selected young patients are shown on Table 1. Fifty-one percent (n=101) were men. The average age was 32.9 years (range 11-40). Family history of cancer was found in 36.22% (n=71), and ... See full document

... Colorectal cancer is one of the most common neoplasms and a leading cause of death ...made in order to gain new insight into its aetiology and how environmental and genetic factors influence the ... See full document

... rs1801157 in tumor ...metastasis in the following 5 ...analysis in order to determine a putative correlation between the disease progression and rs1801157 using Kaplan-Meier ...lower in ... See full document

... of colorectal cancer (CRC) in the US has ...observed in non-Hispan- ic Whites, Blacks, and ...CRC in Hispanics living near the ...CRC in non-Hispanic Whites and Hispanics living ... See full document

... lymphocytes in colon cancer is more obvious with longer follow-up periods ...Moreover, in follow-up studies conducted on patients with high or low levels of CD8, survival curves during the first two ... See full document

... implicated in promotion of EMT in vitro ...step in PGE 2 synthesis, upstream of PGE synthases ...up-regulated in CRC and is a putative target for anti-CRC therapy ...step in PGE 2 ... See full document

... improvements in OS or PFS upon treatment with cetuximab, regardless of chemotherapy regimen or somatic KRAS ...lie in the independent biological roles played by the different mutations of ...lie in ... See full document

... state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, and ...National ... See full document

... located in the nucleus and cytosol, distributed in a very similar way to ...APC. In addition, its silencing causes increase in nuclear size, displacement of the cell cycle profile, errors ... See full document

... dormant in the human body for years without causing disease, a state referred to as latent tuberculosis ...tuberculosis in vitro ...proteins in exosomes isolated from the serum of TB patients ... See full document

... mortality in rectal tumours, while longer diagnos- tic intervals were not associated to a lower survival in rectal or colon ...[21–23]. In any case, the conclusion is similar: patients with short and ... See full document

... Disease Cancer, ...national cancer in- cidence, mortality, years of life lost, years lived with disability, and disability-ad- justed life-years for 32 cancer groups, 1990 to 2015: a ... See full document

... fosfolípidos. In vitro, la sobreexpresión del miR redujo entre otros genes los niveles de expresión de la enzima lisofosfatidilglicerol aciltransferasa (LP- GAT1, lysophosphatidylglycerol acyltransferase 1), que ... See full document

... (stored in different on-line repositories) from 1100 colorectal cancer ...II colorectal tumors in three large subtypes named CCS1, CCS2 and CCS3 (CCS, Colorectal Cancer ... See full document