[PDF] Top 20 Impacto da saúde oral na qualidade de vida de jovens entre os 11 e os 14 anos
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FGFR1 underlies obesity-associated progression of estrogen receptor–positive breast cancer after estrogen deprivation
... diet-induced obesity in the C57BL/6 mouse strain (22, 23), the reduced immune function of the Rag1-null mutation (24), and thermoneutral hous- ing conditions, which support obesity development in ... See full document
22
Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor positive breast cancer
... To identify novel mechanisms of resistance to E- deprivation, we first generated five LTED cell lines. wt- MCF7, wt-ZR75.1, wt-T47D, wt-HCC1428 and wt-SUM44 cells were cultured in the absence of E2 until their ... See full document
13
FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors – implications for therapy of luminal breast cancer
... with FGFR1-overexpressing tumours subjected to adju- vant tamoxifen-based therapy verified results of experi- mental ...studies. FGFR1 signalling was shown to suppress PR expression in vitro and this was ... See full document
242
Functional variants at the 21q22 3 locus involved in breast cancer progression identified by screening of genome wide estrogen response elements
... of breast cancer focused on cancer incidence, we addressed the importance of genetic polymorphisms in determining breast cancer ...in breast cancer ...are ... See full document
7
Estradiol induces HOTAIR levels via GPER mediated miR 148a inhibition in breast cancer
... ER-positive breast cancer cells, it has been dem- onstrated that HOTAIR is transcriptionally induced by E2 through multiple functional EREs in its promoter ...[20]. Estrogen receptors (ERs), ... See full document
10
Understanding the mechanisms underlying the joint action of xenoestrogens
... progesterone receptor (PR), which were transfected into CV1 monkey kidney ...MCF-7 breast cancer cells, suggested an interaction between growth factor signalling and ER pathways (Vignon at ... See full document
5
BRCA1 And Estrogen/Estrogen Receptor In Breast Cancer: Where They Interact?
... for cancer development mainly in estrogen responsive tissues such as breast and ...and estrogen receptor) signaling synergistically regulate the mammary epithelial cell proliferation ... See full document
58
Promestriene Affects GREB1 Expression in Estrogen Sensitive Breast Cancer Cells
... synthetic estrogen analog that has been reported to significantly improve the symptoms of vaginal atrophy caused by estrogen deprivation in topical application [6] ...observed after vaginal ... See full document
7
Correlation of Four Receptors Expression and Lymph Node Metastasis in Sudanese Breast Cancer Patients
... progesterone receptor B is the full length receptor while the progesterone receptor A and C are amino terminal truncated ...the breast and anti proliferative in the ovaries and reproductive ... See full document
32
Controllable drug uptake and nongenomic response through estrogen-anchored cyclodextrin drug complex
... while no significant response was observed in normal breast MCF-10A cells. Cells treated with CDE 1 at 1 µ M showed a maximum p44/p42 MAPK phosphorylation at Thr202/ Tyr204 at 15 minutes drug exposure and ... See full document
79
Estrogen receptor transcription and transactivation Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer
... the estrogen receptor regulates transcription Although the DNA binding domains of ERα and ERβ are nearly identical, there is considerable documentation that these receptor subtypes differ markedly in ... See full document
20
A Novel Combined Approach for Metastatic Breast Cancer with Dural and Leptomeningeal Disease with an Impressive Clinical Outcome: A Case Study
... PR-weak positive, HER2 negative multifocal ductal carcinomas of the left breast declined adjuvant tamoxifen and RT after a left lumpectomy and negative senti- nel node ... See full document
12
A Review of Chromatographic Methods Used in the Determination of Anastrozole Levels
... Many different chromatographic methods have been reported for ANA quantification, both in pharmaceutical dosage formulations and in biological matrices. Some HPLC methods with sensitivity as high as 0.0165 µg/ml LOQ have ... See full document
7
Effectiveness of tocotrienol rich fraction combined with tamoxifen in the management of women with early breast cancer: a pilot clinical trial
... of breast cancer, and 36 patients (16 in the intervention group versus 20 in the control group) had local or systemic ...of breast cancer, whereas 39% of patients in the TRF-plus-tamoxifen ... See full document
21
Mechanisms of endocrine resistance in breast cancer: an overview of the proposed roles of noncoding RNA
... in breast cancer patients have been stud- ied at diagnosis, in early stage tumors, after surgical re- section, following chemotherapy/radiation treatments, and following metastatic relapse – all to ... See full document
19
Local estrogen axis in the human bone microenvironment regulates estrogen receptor positive breast cancer cells
... ER+ breast cancers are effectively treated with three types of endocrine therapies: (i) selective estrogen receptor mod- ulators (SERMs), which block estrogen access to the estro- gen ... See full document
19
Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype
... of breast cancers that developed between 1976 and 2000 among women enrolled in the ...as positive when there was stain- ing in >1% of the tumor cell nuclei in any of the three cores from that case, and ... See full document
23
Upregulation of HSF1 in estrogen receptor positive breast cancer
... in breast cancer is not well ...in breast cancer samples from the Nurses’ Health Study using immunohistochemistry ...The Cancer Genome Atlas (TCGA), as well as by performing ... See full document
128
Association of multiple genetic variants with breast cancer susceptibility in the Han Chinese population
... of breast cancer associated with risk factors, which did not include age at menarche, age at first live birth and family history of ...people breast cancer cases and matched ... See full document
140
Clinical outcomes after palbociclib with or without endocrine therapy in postmenopausal women with hormone receptor positive and HER2 negative metastatic breast cancer enrolled in the TREnd trial
... metastatic breast cancer (mBC) have seen cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors, given in combination with endocrine therapy (ET), approved in the USA and in Europe for the first-line treatment ... See full document
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