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Research Paper: Optimization of Transient Focal Cerebral Ischemia Model by Middle Cerebral Artery Occlusion
... Animal model that in addition to the limited damage to ischemic core area can cause a delayed death in the cortex has acceptable similarity to human ischemia ...creating ischemia similar to humans in ...
Parecoxib is neuroprotective in spontaneously hypertensive rats after transient middle cerebral artery occlusion: a divided treatment response?
... inhibitor, and registered as the only COX-2 inhibitor for intravenous (IV) administration. It is a pro-drug and hydrolyzed to the active metabolite valdecoxib. The abil- ity of valdecoxib and other COX-2 inhibitors to ...
The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury
... after focal ischemia [76–79] ...suture model of middle cerebral artery (MCA) occlusion can result in reduced blood supply to the LVCP [76] as the branch point for the AChA ...
Control of occlusion of middle cerebral artery in perinatal and neonatal mice with magnetic force
... MCA occlusion (MCAo) can be performed in P7 rats [7–10], unfortunately MCAo is not feasible for mouse pups this ...to model IPS in mice because they are the most commonly genetically edited ...permanent ...
Vasospasm and delayed cerebral ischemia after uneventful clipping of an unruptured intracranial aneurysm – a case report
... A 69-year-old woman developed a sudden drooping on the left side of the face while having dinner with her family. Her daughter noticed slurred speech and alerted emergency medical services immediately. The patient was ...
Kudiezi injection mitigates myocardial injury induced by acute cerebral ischemia in rats
... 6-h ischemia and that the function of sympathetic and parasympathetic nerves might be affected after acute cerebral ischemia, which might be associated with sec- ondary heart ...with cerebral ...
Time Threshold Curve Determined by Single Photon Emission CT in Patients with Acute Middle Cerebral Artery Occlusion
... in patients with acute ischemic stroke (1, 2, 5, 17–21). Within the first 3 hours, the discriminant line rapidly rose to 45.5% of contralateral presumed normal CBF. Thereafter, it very gradually rose from 49.8% to 52.3% ...
MR and CT investigation of cerebrovascular disease in sickle cell patients
... 2; case 4, apparent right middle cerebral artery occlusion ipsilateral to infarction in middle cerebral artery distribution; case 5, severe stenosis of the terminal right internal caroti[r] ...
Apigenin-7-O-β-D-(-6''-p-coumaroyl)-Glucopyranoside Treatment Elicits Neuroprotective Effect against Experimental Ischemic Stroke
... global cerebral ischem- ic/reperfusion model of mice, as evidenced by im- proved neurological function and increased survival ...a transient rat MCAO ...the middle dose ...
Calcium 45 autoradiography and dual isotope single photon emission CT in a canine model of cerebral ischemia and middle cerebral artery occlusion
... canine model for cerebral ischemia (5), we sought to assess whether a temporary ischemic insult could be differentiated autoradiographically from a per- manent ...this model, further ...
Tissue at Risk Is Overestimated in Perfusion Weighted Imaging: MR Imaging in Acute Stroke Patients without Vessel Recanalization
... of occlusion types, al- though 189 candidates for thrombolysis have been screened by MR imaging within 6 hours of the onset of ...Persisting occlusion without any region of reperfusion on follow-up imaging ...
Infiltration and persistence of lymphocytes during late-stage cerebral ischemia in middle cerebral artery occlusion and photothrombotic stroke models
... Additional file 3: ROS generation and lymphocytes infiltration in photothrombosis model with lymphocytes pre- or post-stroke transfer. Lymphocytes were isolated from spleens of C57BL/6 mice. 2 × 10 7 isolated ...
Dimeric Dipeptide Mimetics of NGF and BDNF Are Promising Agents for Post Stroke Therapy
... In a series of experiments to study the neuroprotectie effects of GK-2 with the treatment beginning within different time after reperfusion it was determined that dipeptide had a wide “therapeutic window”. GK-2 ...
VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain
... The extent of the edema formation was obtained by delineating the regional cortical hyperintensity by eye from the T2-weighted MRI data obtained 24 hours after ischemia (a single experimenter who was blinded to ...
Large infarcts in the middle cerebral artery territory: Etiology and outcome patterns
... laMCA = large middle cerebral artery; lsMCA = limited superficial middle cerebral artery; coMCA = complete infarction of middle cerebral artery; lasoMCA = large superficial [r] ...
MR detection of secondary changes remote from ischemia: preliminary observations after occlusion of the middle cerebral artery in rats
... PURPOSE: To determine whether secondary MR changes occur in the thalamus or the substantia nigra after middle cerebral artery (MCA) occlusion in rats. METHODS: Sprague-Dawley rats were ...
Angioplasty of the occluded internal carotid artery
... a middle cerebral artery occlusion in whom in addition to the middle cerebral artery thromboembolus, an internal carotid artery occlusion has been present, ...
Safety and efficacy of delayed intraarterial urokinase therapy with mechanical clot disruption for thromboembolic stroke
... On initial angiographic studies, there were two cases of basilar occlusion, one posterior cerebral artery occlusion, seven cases of isolated middle cerebral artery or combined internal c[r] ...
Original Article Efficacy of human urinary kallidinogenase in ischemic stroke in animal models: a meta-analysis
... major research endeavor. Using experimental focal cerebral ischemia models (most often middle cerebral artery occlusion [MCAO]) that mimic acute stroke under strict ...
The role of rutin in focal cerebral ischemia: oxidative stress factors and rotarod test
... Stroke is one of the principal causes of death and disability worldwide. Ischemic stroke constitutes 85% of all stroke cases. No effective treatment has been established to prevent damage to the brain (1). Ischemic ...