[PDF] Top 20 Regulation of NMDA Receptor Synaptic Transmission by Wnt Signaling
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Regulation of NMDA Receptor Synaptic Transmission by Wnt Signaling
... mediated by NMDARs or AMPARs in cultured orga- notypic hippocampal ...various Wnt ligands. Wnt-5a, a noncanonical ligand (Gordon and Nusse, 2006), produced a two-step increase in the amplitude ... See full document
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Modulation of the NMDA Receptor Through Secreted Soluble Factors
... context, Wnt-5a also exhibits a protective role against the reduced expression of NMDAR and PSD-95 through A β oligomers ...Indeed, Wnt-5a occludes the Aβ-mediated synaptic depression ... See full document
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Syndecan 4 inhibits Wnt/ß catenin signaling through regulation of low density lipoprotein receptor related protein (LRP6) and R spondin 3
... enhances Wnt/-catenin ...quantification of the knockdown efficiency) using a siRNA (siSdc4) enhances the activation of the TOPFlash reporter in response to increasing concentrations of Wnt3a ... See full document
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Wnt signaling in the regulation of adult hippocampal neurogenesis
... non-canonical Wnt pathways have relevant roles in the adult ...the Wnt-5a ligand able to activate non- canonical Wnts cascades (Farias et ...in synaptic structure and func- tion. Wnt-5a ... See full document
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WASP 1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by A beta oligomers
... several Wnt ligands, WASP-1 can modulate excitatory synaptic transmission by increasing the synaptic strength of CA3 – CA1 hippocampal synapses (Beaumont et ...perfusion ... See full document
12
Synaptic Wnt/GSK3β Signaling Hub in Autism
... analysis of biochemical and pharmacological data, animal models of the disease, and genetic association studies, we predicted earlier that the onset/development of ASDs might involve the additive ... See full document
11
Wnt 7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons
... recycling of synaptic vesicles, Wnt-7a was the more active Wnt factor, and its ability to increase the number of active recy- cling sites was completely abolished by the ... See full document
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Wnt 5a occludes A beta oligomer induced depression of glutamatergic transmission in hippocampal neurons
... whether Wnt-5a prevents the loss of synaptic contacts induced by A b oligomer treat- ...number of synaptic PSD-95 opposite to total synapsin-1 clusters and found that A b ... See full document
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WNT signaling in neuronal maturation and synaptogenesis
... range of neuropsychiatric features, massive neuronal degeneration, and neither preventive nor effective long- term treatment strategies ...all of them develop in particular brain regions generating a ... See full document
11
AMPA receptor stabilization mediated by non canonical Wnt signaling protects against Aβ42 oligomers synaptotoxicity
... reflection of the relevance of AMPARs in synaptic ...followed by cerebellum and cortex (Schwenk et ...ratio of PSD95:AMPARs:NMDAR molecules is 15:3:1 (Sheng and Hoogenraad, ...soma ... See full document
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In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model
... magnitude of fEPSP amplitude suggests that WASP-1 and FOXY-5 treatments enhance synaptic strength between CA3-CA1 hippocampal con- ...Measurements of fEPSP amplitude showed that WASP-1- and ... See full document
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Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1 Delta E9 mouse model of Alzheimer's disease
... characterized by a progressive deterioration of cognitive abilities, accumulation of the amyloid-b-peptide (Ab) and synaptic ...activated receptor-c agonist, has been shown to attenuate ... See full document
15
Wnt signaling: Role in LTP, neural networks and memory
... that Wnt is present or constitutively released during basal synaptic ...logical Wnt signaling inhibitor, Rosso and colleagues have shown that there is a significant reduction in the number ... See full document
15
Antagonistic effects of TrkB and p75(NTR) on NMDA receptor currents in post synaptic densities transplanted into Xenopus oocytes
... sites of synaptic receptor clustering and signal integration in dendritic spines at excitatory synapses (Kennedy 2000; Kim and Sheng ...the NMDA receptor (NMDA-R) is a core ... See full document
13
Involvement of WNT signaling pathway in the adult hippocampal synapses :role in neuroprotection
... type-A transmission. Recording of field excitatory postsynaptic potentials (fEPSP) was carried out with a glass pipette (2–4 megaohms, filled with ACSF), placed in the middle of stratum radiatum ... See full document
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Wnt Signaling: Role in Alzheimer Disease and Schizophrenia
... tion of synapses is a relevant contributor for neurodevelop- mental ...mediated by a dys- regulation of the Wnt signaling ...This Wnt defect induces protein degradation, ... See full document
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Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20 APP transgenic and wild type mice
... The Wnt signaling pathway regulates synaptic transmis- sion and plasticity in the adult brain (Inestrosa and Varela- Nallar 2014, ...canonical Wnt pathway is activated when the Wnt ... See full document
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Canonical Wnt signaling protects hippocampal neurons from A beta oligomers: role of non canonical Wnt 5a/Ca2+ in mitochondrial dynamics
... activation of the canonical Wnt signaling pathway in hippocampal neurons pre- vents the neurotoxicity triggered by Aβ aggregates formed by amyloid fibrils (Alvarez et ...activation ... See full document
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alpha Amino 3 hydroxy 5 methyl 4 isoxazole Propionic Acid (AMPA) and N Methyl D aspartate (NMDA) Receptors Adopt Different Subunit Arrangements
... frequency of 600 – 1000 kHz in water and a spring constant of ...tilever by electron beam deposition using a Nanotools device (Munich, ...70% of this value. A droplet (3 l) of ... See full document
13
Control of the neurovascular coupling by nitric oxide dependent regulation of astrocytic Ca2+ signaling
... evoked by electrical field stimulation of brain slices from wild type animals, but not from TRPV4 knockout mice (Dunn et ...evaluation of the cerebral hemodynamic response in vivo by measuring ... See full document
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