PDF superior Study on Renal Function in Patients with Subclinical Hypothyroidism Response to Treatment with Levothyroxine

Study on Renal Function in Patients with Subclinical Hypothyroidism  Response to Treatment with Levothyroxine

Study on Renal Function in Patients with Subclinical Hypothyroidism Response to Treatment with Levothyroxine

GFR was calculated using the MDRD4 (Modification of Diet of Renal Disease) formula: 186 x (creatinine) -1,154 x (age) -0,203 x (0.7402 if female) x (1.210 if black) and patients were grouped into stages: GF > 90 ml/min (S1 or normal), 89-60 ml/min (S2), 59-30 ml/min (S3) and < 30 ml/min (S4), according to K/DOQI 2002 of the National Kidney Foundation.

5 Lee mas

Tumor del lecho placentario asociado a nefropatía por IgA como manifestación paraneoplásica: reporte de caso

Tumor del lecho placentario asociado a nefropatía por IgA como manifestación paraneoplásica: reporte de caso

Treatment. The cornerstone in the treatment of IgA nephropathy in the general population is the use of renin-angiotensin-aldosterone system blockers (angiotensin converting enzyme [ACE] inhibitors or aldosterone receptor antagonists [ARA II]), together with salt intake restriction to less than 5 g per day and tight blood pressure control (< 125/75 mm/Hg). In patients with concomitant nephrotic syndrome, adding steroids at a dose of 0.5-1 mg/kg/day for 4-6 weeks is recommended (14, 23). In cases with no nephrotic syndrome or renal function decline, 3 to 6 months must be allowed in order to assess response to ACEi or ARAII treatment; if proteinuria remains above 1 g, prednisolone 0.5-1 mg/kg/day for 6 months must be added. During pregnancy, the use of ACE inhibitors and ARA II is contraindicated and treatment is therefore based on salt intake restriction. Monitoring is based on creatinine and proteinuria in 24-hour urine, and remission is considered to have been achieved when proteinuria comes down to less than 500 mg/24 h (14, 23).
Mostrar más

8 Lee mas

Heart failure and thyroid dysfunction

Heart failure and thyroid dysfunction

Chronic hypothyroidism in adult rats leads to the loss of coronary arterioles and impaired blood flow; it induces maladaptive changes in the shape of myocytes and the development of HF (19). Important changes in cardiac structure and function have been reported in patients with overt and subclinical hypothyroidism (SHypo) with a severity depending on the degree and the duration of thyroid hormone deficiency (14, 15, 16, 77, 78, 79). Hypothyroidism is characterized by a low cardiac output due to the decreased heart rate and stroke volume (15, 16). Systolic and diastolic functions are reduced at rest and during exercise, thus impairing quality of life (80). Cardiac preload is decreased due to the impaired diastolic function and the decreased blood volume (78). Vascular function may also be deranged in overt and mild thyroid hormone deficiency (78, 79, 81). Renal perfusion is decreased with a consequent reduction in glomerular filtration, impaired free water clearance and hyponatremia (15). The cardiac energetic efficiency of the hypothyroid human heart is impaired despite its reduced cardiac oxygen consumption (15). Moreover, important metabolic effects may develop in long-term untreated hypo- thyroidism (74, 75). An increased cardiovascular risk has been reported in patients with various degrees of hypothyroidism (74, 75). This may be linked to the increased risk of coronary artery disease and HF associated with hypothyroidism (11, 82, 83). In parti- cular, an increased risk of coronary heart disease events and mortality has been reported in young patients affected by SHypo with TSH O10 mU/l (83, 84).
Mostrar más

10 Lee mas

Vitamin C improves the apparent absorption of levothyroxine in a subset of patients receiving this hormone for primary hypothyroidism

Vitamin C improves the apparent absorption of levothyroxine in a subset of patients receiving this hormone for primary hypothyroidism

present in 33 of 2450 patients who attended our center, with a prevalence of 1.34 %; the other 8 patients did not want to participate in the study. The mean daily dose was 147.19 ± 36.47 µg/day, and the mean body weight 69.43 ± 14.59 kg. None of the patients were taking medication known to interfere with LT4 absorption/metabolism (Table I), nor were they known to have gastrointestinal diseases that could alter LT4 absorption (Table I). Gastrointestinal or liver diseases were excluded by absence of symptoms of impaired gastric acid secretion or intestinal malabsorption and, when possible, through laboratory investigations. All 28 patients had normal liver function tests and antibodies against gliadin and endomysium were negative, and 8/28 had parietal-cell antibodies measured and were negative. Carbon-13-labeled- urea breath test, used to diagnose Helicobacter pylori infection, was performed in 14/28 patients and was negative in all cases. Twenty of the 28 patients had psychiatric evaluation in order to exclude non-compliance. Five patients had been on a lactose-free diet before vitamin C co-administra- tion, with no change in TSH level. Other potential causes of LT4 malabsorption or accelerated LT4 metabolism were not studied.
Mostrar más

9 Lee mas

Prevalencia de alteraciones en las pruebas de funcin tiroidea y anticuerpos antitiroideos en poblacin adulta del centro de Mxico

Prevalencia de alteraciones en las pruebas de funcin tiroidea y anticuerpos antitiroideos en poblacin adulta del centro de Mxico

Some studies have demonstrated that patients with TSH ≥ 3.5 mIU/L have more frequent hypothy- roidism-related clinical symptoms. In this study, pa- tients with TSH values above 3.5 mIU/L were more symptomatic; however, our results demonstrated that most of the patients with subclinical disease did not seek medical attention and did not pay at- tention to subtle clinical symptoms. Thus, further studies are necessary to understand the impact of these symptoms on quality of life, well-being and job performance. Also we included headache and hair loss as symptoms to be asked in the questionnaire due to we have observed that patients with hypothy- roidism frequently complain of this symptoms, and when we did the statistical analysis we found there was difference between the patients with hypothy- roidism and those who do not have abnormal thyroid tests, in consequence we think it is neces- sary to explore these symptoms in other clinical studies in order to confirm this finding based on clinical practice experience. Recent controlled trials administering levothyroxine failed to demonstrate any improvement in clinical symptoms and quality of life with levothyroxine administration in patients with sub-hypo and there is insufficient evidence that levothyroxine treatment improves the lipid profile, cardiac dysfunction or decreases fracture risk. 23,24
Mostrar más

8 Lee mas

Descargar
			
			
				Descargar PDF

Descargar Descargar PDF

Conclusions: Although overall survival rate is the gold standard in cancer therapy, it is not the most often used outcome. Intermediate outcomes, such as disease-free survival or biomarkers are often good predictors, and require smaller samples and less follow-up time. Nevertheless, their predictive capacity for overall survival rate (or, in some cases, quality of life) should also be assessed. The use of the overall survival rate as the routine primary outcome is only justified in the most aggressive forms of cancer.

8 Lee mas

Is pre treatment liver biopsy necessary for all hepatitis C genotypes?

Is pre treatment liver biopsy necessary for all hepatitis C genotypes?

In the second phase of EAP, there was no requi- rement for a liver biopsy to enroll patients. The de- cision was left to the usual clinical practice of the participating physician. Any biopsies performed on patients enrolled in the EAP were read by the presi- ding local pathologist at each study site. For those who underwent liver biopsy, grading of inflamma- tion and staging of fibrosis were analyzed accor- ding to the METAVIR scoring system. Only the most recent biopsy result was recorded on the case report form. For patients who were treated without a liver biopsy, the reason for not perfor- ming a liver biopsy was not collected on the case report forms.
Mostrar más

10 Lee mas

Determinación de interleucina-10 (IL-10) en pacientes con cáncer en estadios III y IV tratados con dexametasonaDetermination Of Interleukine-10 In Cancer Patients In Stages Iii And Iv Treated With Dexamethasone.

Determinación de interleucina-10 (IL-10) en pacientes con cáncer en estadios III y IV tratados con dexametasonaDetermination Of Interleukine-10 In Cancer Patients In Stages Iii And Iv Treated With Dexamethasone.

description Dexamethasone treatment in patients with cancer in stages III and IV is associated with immune response.. suppression, possibly because of the inhibiting effect produced by a[r]

3 Lee mas

Hairy cell leukemia, an uncommon B cell lymphoid neoplasia

Hairy cell leukemia, an uncommon B cell lymphoid neoplasia

As described earlier, BRAF V600E mutation is the genetic key in HCL. Therefore, it is a therapeutic target which has been studied in recent years. Vemurafenib is a BRAF V600E oral inhibitor. Tiacci et al. conducted a study to measure Vemurafenib activity and safety in patients with HLC who relapsed after treatment with purine analogues or who were refractory to the administration of purine analogues. Global response rate was 96% and complete response rate was 35%, with a relapse-free survival mean of 19 months. The adverse effects were rash, arthralgia and arthritis. 63
Mostrar más

8 Lee mas

Drug Prescribing in Patients with Impaired Renal Function: are Interventions Still Needed to Improve Patient Safety?

Drug Prescribing in Patients with Impaired Renal Function: are Interventions Still Needed to Improve Patient Safety?

KEY WORDS: Chronic kidney disease, Cockcroft-Gault, Drug dosage, Medication error, Modification of diet in renal disease, Pharmaceutical care.. * Author to whom correspondence should be[r]

1 Lee mas

Endothelin 1, high sensitivity C reactive protein and antioxidant activity in subclinical hypothyroid                    patients  Effects of levothyroxine treatment

Endothelin 1, high sensitivity C reactive protein and antioxidant activity in subclinical hypothyroid patients Effects of levothyroxine treatment

Material and methods: 70 patients were prospectively evaluated. They were classified into: SH Group: 41 patients (normal T4, TSH> 4.2 and <10 mIU/L), TAI Group: 10 euthyroid patients (TSH <4.2 mUI/L) with positive aTPO and/or aTg and Control Group: 19 euthyroid patients without TAI. Other cardiovascular risk factors were excluded in patients and controls. Plasma ET1, hsCRP and TRAP were measured basally, and ET1 and hsCRP under LT4 therapy in the HS Group.

5 Lee mas

Mortality prediction of cirrhotic patients admitted to the Intensive Care Unit

Mortality prediction of cirrhotic patients admitted to the Intensive Care Unit

In summary, this study suggests that patients with se- vere fibrosis are more likely to have TD and to require treatment for TD during therapy with Peg IFN than those with mild fibrosis. We postulate that risk for TD may be associated to immune processes allied to the progression of fibrosis in patients with HCV. In our opinion, this study is of clinical interest and the first to study TD among different stages of fibrosis in HCV. Patients with more advanced chronic hepatitis C require closer follow up to diagnose and manage TD, including a high level of suspicion for thyroid carcinoma. This is particularly im- portant in sub populations with more rapid liver disease progression as Latinos, HCV/HIV co-infected patients and HCV patients with concomitant alcohol use.
Mostrar más

6 Lee mas

Clinical response in patients with ovarian cancer treated with  metronomic chemotherapy

Clinical response in patients with ovarian cancer treated with metronomic chemotherapy

Patient 5: A 52-year-old female, with a background of hypothyroidism, presented with abdominal distention and a pelvic tumour in a CT scan. She was diagnosed with a stage IIIC infiltrating endometrioid ovarian adenocarcinoma. She received surgery and standard chemo- therapy with a total of three lines of treatments. After progression, she started MCT Cy (50 mg p.o.d) with a minimal hematological toxicity. MCT began in September 2014 with no interruptions and, at present, the patient continues the treatment. The patient’s condition remained stable with good QOL (ECOG 1). The patient is still alive (June 2016) with 21 months of PFS at the moment of manuscript writing. Patient 6: A 54-year-old woman was diagnosed with a stage IIIC papillary ovarian adenocarcinoma. Pre-operative CA125: 1648 U/ml; she underwent optimal cytoreductive surgery and received adjuvant chemotherapy. She received two lines of chemotherapy, a new surgery of the peritoneal masses and hormonal treatment before MCT. She was treated with MCT (Cy 50 mg p.o.d) with good tolerance and stable disease for 12 months. She received MCT from December 2013 to December 2014. After that period, the tumour progressed and she began a scheme with targeted therapy (bevacizumab) plus chemotherapy with partial response, severe toxicity and rapid progression. The patient is still alive and is under liposomal doxorubicin (LSD) chemotherapy at the moment of manuscript writing.
Mostrar más

10 Lee mas

Falla cardíaca avanzada en pacientes tratados con dispositivos electrofisiológicos en una unidad de electrofisiología, Pereira (Colombia)

Falla cardíaca avanzada en pacientes tratados con dispositivos electrofisiológicos en una unidad de electrofisiología, Pereira (Colombia)

trica en Europa (12, 15), ha madurado la tecnología actual indicada para la terapia de cardioresincronización y cardiodesfib- rilación en el manejo avanzado de la IC. Estas terapias están avaladas por ensayos clínicos con más de 7000 pacientes re- clutados y seguidos hasta por 37 meses (16), y son parte de las guías de manejo basadas en la evidencia a nivel mun- dial (17). La terapia de resincronización cardíaca con cardiodesfibrilador ha dem- ostrado un beneficio significativo en la reducción de la mortalidad: 18 al 23% por IC, 43% en la mortalidad global, 18% en hospitalización por empeoramiento de falla subyacente y otros beneficios como la mejoría en la capacidad funcional, caminata de 6 minutos, difusión de CO 2 , parámetros hemodinámicos y de mecáni- ca cardíaca contemplados como benefi- cios adjuntos a estas terapias (18). A escala global, el impacto de estas in- tervenciones se ha estimado entre los 48.000 y 112.000 euros por año con rel- ación al costo del dispositivo, su implan- te y monitoreo temprano; sin considerar otros gastos directos e indirectos que se derivan (19).
Mostrar más

11 Lee mas

A multifaceted intervention to improve treatment with oral anticoagulants in atrial fibrillation (IMPACT-AF): an international, cluster-randomised trial

A multifaceted intervention to improve treatment with oral anticoagulants in atrial fibrillation (IMPACT-AF): an international, cluster-randomised trial

The design and rationale of the IMPACT-AF trial has been described previously.12 Briefly, IMPACT-AF was a two-arm, prospective, international, cluster-randomised, controlled- trial that enrolled patients with atrial fibril- lation. IMPACT-AF was designed as a cluster-randomised study to provide a randomised control group, while minimising the presence of contamination that might occur with individual randomisation, given that the implementation of the educational intervention was applied at both the cluster and individual level. The national coordinating centres from five participating middle-income countries (Argentine Clinical Research Group [ACRG], Rosario, Argentina; Brazilian Clinical Research Institute, São Paulo, Brazil; Peking University First Hospital, Beijing, China; St John’s Medical College and Research Institute, Bangalore, India; and University of Medicine and Pharmacy Carol Davila, Bucharest, Romania) were responsible for the conduct of the trial in each respective country. Clusters (sites) were identified by each coordinating centre based on feasibility and patient volume. All clusters demonstrated access to adequate numbers of eligible patients by providing pre-screening lists of 40–90 eligible patients.
Mostrar más

16 Lee mas

Treatment of nonalcoholic steatohepatitis with probiotics  A proof of concept study

Treatment of nonalcoholic steatohepatitis with probiotics A proof of concept study

The primary endpoint was the reduction in IHTG from baseline to month 6 as measured by proton-magnetic resonance spectroscopy. Seconda- ry endpoints included changes in ALT, aspartate aminotransferase (AST), BMI, fasting glucose, li- pids and liver stiffness measurement by transient elastography. Liver stiffness measurement was per- formed using the Fibroscan machine (Echosens, Paris, France). The procedure was performed according to the manufacturer’s instructions as described previously. 23,24 Liver stiffness measure-

7 Lee mas

El estado de inmunocompetencia determina el pronóstico en los pacientes sépticos

El estado de inmunocompetencia determina el pronóstico en los pacientes sépticos

A single blood sample was obtained from each patient or control in tubes containing ethylenediaminetetraacetic acid (EDTA) within the first 24 hours following diagnosis of septic shock or SIRS. Plasma samples were obtained after proper centrifugation and these were stored at -80 ◦ C until cytokine profiling. Plasma chemokine and cytokine levels were evaluated using the multiplex Biorad © 17 plex assay, following manufacturer’s instructions. This system allows for quantitative measurement of 17 differ- ent chemokines, cytokines, growth-factors and immune mediators, while consuming only a small amount of biological material. Furthermore, this system has good rep- resentation of analytes for inflammatory cytokines, anti- inflammatory cytokines, Th1 cytokines, Th2 cytokines, Th17 cytokines and chemokines, allowing for testing of different levels of regulatory cytokines in patients’ plasma. Limits of detection were as follows (pg/mL): IL-1b (2,4); IL-6 (2,1); IL-8 (1,8); IL-7 (2,4); IL-17 (2.1); G-CSF (1,5); MCP-1 (1,8); MIP-1b (1,4); IL-2 (1,3); IL-4 (0,2); IL-5 (2,5); IL-10 (1,8); IL-12(p70) (2,6); IL-13 (2,6); GM-CSF (0,7); IFN-␥ (2,4); TNF-␣ (6,4).
Mostrar más

148 Lee mas

Treatment with Metadoxine and its impact on early mortality in patients with severe alcoholic hepatitis

Treatment with Metadoxine and its impact on early mortality in patients with severe alcoholic hepatitis

The distribution of variables was analyzed; in case of quantitative variables with a non-normal distribution base, a 10-logarithmic transformation was performed to normalize their distribution. De- scriptive statistics were used, quantitative variables were expressed as the mean and standard deviation (SD), and qualitative variables were expressed as proportions and percentages. Analysis with inten- tion to treat (ITT) was conducted. To compare pri- mary and secondary outcomes between groups, the chi-square test, Fisher’s exact test or Student’s t- test was used, based on the variable type. Survival analysis was performed using Kaplan-Meier curves for up to 30 and 90 days, respectively, and compared with the log-rank test.
Mostrar más

10 Lee mas

Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes

Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes

It also proved impossible in the present study to predict acute or late effects from the results of an in vitro assay to measure initial radiation-induced DNA damage. Until recently, it has been generally accepted that the genotoxic consequences of radiation exposure derive from the damage inflicted directly by radiation, producing irreversible changes during DNA replica- tion or cell division or during the processing of DNA damage by enzymatic repair processes [24]. However, there is now considerable evidence that cells that are the progeny of exposed cells but that are not themselves exposed may divide, express delayed gene mutations, and carry chromosomal aberrations. This effect, known as radiation-induced genomic instability, may be expressed via delayed lethal mutations [25], causing prolonged perturbation of tissue volume within the radiation field [26]. Although the mechanisms of those delayed effects of ionizing radiation are unclear, excessive production of reactive oxygen species has been implicated [27]. Recent experiments showed that macrophage activation and neu- trophil infiltration are consequences of the recognition and clearance of radiation-induced apoptotic cells and that increased phagocytic cell activity persists after removal of apoptotic bodies. It was demonstrated, contrary to expecta- tions, that the recognition and clearance of apoptotic cells after exposure to radiation produces persistent macrophage activation and a genotype-dependent inflammatory-type response [28]. These phenomena and radiation-induced genetic changes may be important determinants of the longer- term consequences of radiation exposure [28]. Moreover, new evidence suggests that cytokine-mediated multicellular inter- actions initiate and sustain the fibrogenic process [29,30] that is a long-term effect of radiotherapy.
Mostrar más

9 Lee mas

Efectividad de terapéuticas alternativas para el manejo del dolor lumbar

Efectividad de terapéuticas alternativas para el manejo del dolor lumbar

spondylopathies (See additional fi les). LDD diagnosis was established in all patients with defi ned diagnosis by a specialist in Neurosurgery, Orthopedics, as a result of complementary tests or diagnosis described in medical re- cords. Separately, two researchers (TAF, TAA) reviewed the medical records and included patients who received 2 or more continuous sessions of some type of AT for the diagnosis of LDD; any uncertainty about the diagnosis was resolved by a third investigator (PLM). Patients who received only one medical inspection, were not treated or had secondary spinal cord injury to neoplasia were exclu- ded (Figure S1, see supplementary fi les).
Mostrar más

12 Lee mas

Show all 10000 documents...