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[PDF] Top 20 TítuloHedgehog signalling as a target in cancer stem cells

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TítuloHedgehog signalling as a target in cancer stem cells

TítuloHedgehog signalling as a target in cancer stem cells

... Hh signalling system is derived from an ancient metabolic pathway ...and signalling in ...serve as efflux pumps to clear toxic drugs from the ...membranes in mammalian cells [4]. ... See full document

12

TítuloWnt signalling and cancer stem cells

TítuloWnt signalling and cancer stem cells

... observations in patients with coronary artery disease and the combined metabolic syndrome with hyper-tension, hyperlipidaemia and DM have observed impaired Wnt signalling through a missense mutation ... See full document

25

Importance and regulation of adult stem cell migration

Importance and regulation of adult stem cell migration

... described as amoeboid migration as the movement resembles that of rounded ...importance as it is observed in 3D environments but rarely in 2D cultures [97, ...breach in the actin ... See full document

9

TítuloProstate cancer and Hedgehog signalling pathway

TítuloProstate cancer and Hedgehog signalling pathway

... intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic ...vertebrates. In some contexts, Hh signals act as ... See full document

12

TítuloNotch signalling in cancer stem cells

TítuloNotch signalling in cancer stem cells

... from stem cells. In this model cancer stem cells (CSC) would be the real driving force behind tumour ...tumour cells that would constitute the bulk of the ...alterations ... See full document

12

Pro oxidant activity of amine pyridine based iron complexes efficiently kills cancer and cancer stem like cells

Pro oxidant activity of amine pyridine based iron complexes efficiently kills cancer and cancer stem like cells

... homeostasis in normal and malignant cells suggests that pro-oxidant- induced upregulation of cellular reactive oxygen species (ROS) should selectively target cancer cells without ... See full document

25

Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells.

Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells.

... colon cancer cell cultures allows the isolation of two subpopulations (TR and TS) that differ in their CSC-like cells ...TS cells show increased ALDH activity, SP proportion and CSC-like ... See full document

13

TítuloBiology of BMP signalling and cancer

TítuloBiology of BMP signalling and cancer

... residues in target proteins. The ubiquitin binding to the target proteins involves a complex of three enzymes that work ...ubiquitin in its carboxy-terminal ...the target protein. ... See full document

15

Targetless T cells in cancer immunotherapy.

Targetless T cells in cancer immunotherapy.

... the target molecules in the tumor micro- environment, unique genetic hits ...T cells among PBMC or TIL, or global mutational load of the cancer cells, just to mention a ...the ... See full document

5

Nuclear expression of Rac1 in cervical premalignant lesions and cervical cáncer cells

Nuclear expression of Rac1 in cervical premalignant lesions and cervical cáncer cells

... Rac1 in a sub- set of L-SIL and H-SIL samples, whereas no nuclear reac- tivity was observed in samples without SIL (Figure ...found in 52.9% L-SIL and 48.4% H-SIL (Table 2). In line with these ... See full document

9

Adipose derived mesenchymal stem cells : are they a good therapeutic strategy for osteoarthritis? / Elena Damiá, Deborah Chicharro, Sergio López, Belén Cuervo, Mónica Rubio, Joaquín Sopena, José Manuel Vilar and José María Carrillo

Adipose derived mesenchymal stem cells : are they a good therapeutic strategy for osteoarthritis? / Elena Damiá, Deborah Chicharro, Sergio López, Belén Cuervo, Mónica Rubio, Joaquín Sopena, José Manuel Vilar and José María Carrillo

... adult cells and since then they have been used to treat chondral defects ...studies in patients with OA treated with BMMSCs obtained good results, reducing the symptoms and, therefore, increasing patient ... See full document

14

Rhythmic profile assessment of breast cancer cell lines and adipose derived stem cells after circadian entrainment

Rhythmic profile assessment of breast cancer cell lines and adipose derived stem cells after circadian entrainment

... 2017) in humans, the circadian system is a complex ...starts in the eye and continues through the pineal ...at in vitro conditions, so it is inferred that internal synchrony is largely governed by ... See full document

62

The future of stem cells in liver diseases

The future of stem cells in liver diseases

... progress in cell bi- ology resulting in the isolation and characterization of hepatic stem cells and progenitor cells further in- creased the expectation for a new approach to ... See full document

9

Células madre mesenquimales para la regeneración de tejidos: ¿Por qué siguen siendo una promesa sin cumplir?

Células madre mesenquimales para la regeneración de tejidos: ¿Por qué siguen siendo una promesa sin cumplir?

... (stem cells) como estirpe celular con capacidad de proliferación y diferenciación ha atraído la atención de la comunidad científica y no científica en todo el ... See full document

10

Nichos hematopoyéticos en médula osea

Nichos hematopoyéticos en médula osea

... ) stem cells are stored in ‘quiescent’ ...niche cells generate a differentiation- and/or division-repressive ...mature cells as required, and might then return to empty niches ... See full document

14

Antiproliferative Effects of Epigenetic Modifier Drugs through E cadherin Up regulation in Liver Cancer Cell Lines

Antiproliferative Effects of Epigenetic Modifier Drugs through E cadherin Up regulation in Liver Cancer Cell Lines

... treatment in the regulation of pathway transcriptional ...levels in HepG2 (A) (A) (A) (A) (A) and HuH7 (B) (B) (B) (B) (B) cell lines, after treatment with 15nM of siRNA non-targeting (siNT) or pool siRNAs ... See full document

17

MOLECULAR MECHANISMS OR T CELLS COSTIMULAION AND COINHIBITION

MOLECULAR MECHANISMS OR T CELLS COSTIMULAION AND COINHIBITION

... ICOS signalling in the C‑MAF and BCL‑6 pathways requires further ...the signalling events downstream of CD28 and ICOS has shown that co‑stimulatory receptors recruit mul‑ tiple proximal ... See full document

16

Efecto de autoinjerto contra tumor

Efecto de autoinjerto contra tumor

... lymphocytes in the autograft directly correlates with clinical outcome after autologous peripheral blood hematopoie- tic stem cell transplantation in multiple ... See full document

6

On a mathematical model of tumor growth based on cancer stem cells

On a mathematical model of tumor growth based on cancer stem cells

... proliferating cells Mp is larger than the degra- dation factor of death cells, and the term kdd is ...of cells chang GS clS cl consequence of the difference of the times of ...of stem ... See full document

16

Bioenergetics mechanism and autophagy in breast cancer stem cells

Bioenergetics mechanism and autophagy in breast cancer stem cells

... growth in soft agar and tumor formation in nude mice, partially establishing a causal role of autophagy induction in malignant transformation (Soung, Lee et ...Ras-transformed cells by ... See full document

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