[PDF] Top 20 TítuloNotch signalling in cancer stem cells

... from stem cells. In this model cancer stem cells (CSC) would be the real driving force behind tumour ...tumour cells that would constitute the bulk of the ...alterations ... See full document

... proliferating cells Mp is larger than the degra- dation factor of death cells, and the term kdd is ...of cells chang GS clS cl consequence of the difference of the times of ...of stem ... See full document

... ) stem cells are stored in ‘quiescent’ ...niche cells generate a differentiation- and/or division-repressive ...mature cells as required, and might then return to empty niches for ... See full document

... allogeneic stem cell transplantation is attributed to tKe graft versus tumor effect produced by tKe infused donor immune effector cells to eradicate tumor ...effector cells is not speci¿c creating ... See full document

... adulthood. Stem cells have an inherent ability to migrate, that is as important as their capacity for self-renewal and differentiation, enabling them to maintain tissue homoeostasis and mediate repair and ... See full document

... Cancer cells have increased steady-state ROS levels and are likely to be more vulnerable to damage by further ROS insults induced by exogenous agents ...explained in terms of resistance to ... See full document

... of cancer stem cells in pancreatic ductal adenocarcinoma (PDAC), and the relevance of this knowledge to generate new and better therapeutic ...years. In USA is placed within the fourth ... See full document

... Stem cells, as classically defined, are cells with a capacity to self-renew and to generate daughter cells that can differentiate down several cell lineages to form all of the cell types that ... See full document

... 2017) in humans, the circadian system is a complex ...starts in the eye and continues through the pineal ...at in vitro conditions, so it is inferred that internal synchrony is largely governed by ... See full document

... We thanks Dr Gambhir’s laboratory from the Standford University for providing L2T plasmid. This work was supported in part by grants from the Ministry of Economy and Competitiveness, Instituto de Salud Carlos III ... See full document

... of signalling for Bmp and other ligands of the TGF-ß superfamily from the cell membrane to the nucleus are carried out in vertebrates by a group of eight intracellular proteins called Smads ...function ... See full document

... overexpression in LNCaP cells leads to increased tumour stromal Gli-1 expression and that Shh overexpression dramatically accelerates tumour ...Hh signalling from prostate cancer cells ... See full document

... expression in hepatocellular carcinoma. In one of these protocols, β-catenin nuclear translocation and the upregulation of genes related to the Wnt/β-catenin pathway, such as Lrp5 and Fzd3, as well as the ... See full document

... role in the metabolic shift that enables somatic reprogramming to stemness because the physiology of mitochondria is inextricably linked to energy metabolism ...of stem cell competence because low ... See full document

... breast cancer development in postmenopausal ...with signalling functions that has been found to be overexpressed in breast ...tin signalling pathways, mediating its effects on survival, ... See full document

... hypermethylated in cancer in hESCs, we compared the DNA methylation and expression status of four of the genes identified in the methylation arrays (MGMT and SLC5A8 [17,18] from Class B-I, and ... See full document

... distinguish cancer (CSCs) from normal stem cells (NSCs) has hindered attempts to identi- fy safer, more effective therapies for hepatocellular carcinoma ...positive stem cells were ... See full document

... Hh signalling system is derived from an ancient metabolic pathway ...and signalling in ...membranes in mammalian cells [4]. Another class of translocators in the bacterial ... See full document

... APC in colorectal carcinoma (CRC) occur mostly in a mutation cluster region that is located approximately in the middle of the coding ...resulting in the generation of truncated APC proteins ... See full document

... intracellular signalling are continuously varied in response to dynamic environmental ...T cells pulling the T cell into func‑ tional ...arise in the face of what often seem to be opposing ... See full document