[PDF] Top 20 TítuloValidation study of genetic biomarkers of response to TNF inhibitors in rheumatoid arthritis

... with response to TNFi that was signifi- cant according with the criteria applied to their discovery studies [15,17,18], but that was less convincing from the statistical point of view (p ... See full document

... cohort of CD patients, the tagging approach allowed us to explore a higher genetic variability within the chromosomal regions where the five genes ...Two of these five top genes are S100A8 and ... See full document

... be to identify the RA stages in which genetic variants exert their maximum influence and also to unveil their clinical significance and usefulness as potential therapeutic targets or ... See full document

... synovium of the 11 RA patients was performed using the Illumina HumanWG-6 expression array system (Illumina, San Diego, CA, ...levels of more than 47,000 different ...USA). In order to use the ... See full document

... Center of Rheumatology and osteoporosis in the Hospital Cen- tral ...range of 17-60 years (arithmetic mean: ...all of the patients were receiving disease-mod- ifying anti-rheumatic ...good ... See full document

... 12 TNF-a is a crucial cytokine in the establishment and maintenance of inflammation in multiple autoimmune and 13 nonautoimmune ...number of large placebo-controlled trials have shown ... See full document

... shown to have important implications in the binding of the receptor to different IgG subclasses ...sponse to IgG-based treatments, like anti-TNF ...differential response ... See full document

... rates of a second TNF antagonist as a surrogate for ...probability of retaining a second TNF antago- nist was lower than retaining the first ...related to the reasons for stopping the ... See full document

... frequent in women than men [10] and emerging data also suggest that women are more likely to present a worse course of the disease and to become severely disabled ...differences in RA ... See full document

... apply to our study in which evalu- ation at 6 months evidenced negative ...cause of discrepant results is the overestimation of the true effect in the discovery ...prevalent ... See full document

... Results of the two nsSNPs for the G1m1,17 allotypes were fully concordant confirming the perfect LD between ...found in unadjusted analysis between lower response (ΔDAS28) and incompatibility at the ... See full document

... Research in rheumatoid arthritis (RA) is increasingly focused on the discovery of biomarkers that could enable personalized ...The genetic biomarkers associated with the ... See full document

... de TNF- α ...del TNF- α , es importante para el desarrollo de nuevas estrategias terapéuticas en AR y otras enfermedades en donde el TNF- α tenga importancia ... See full document

... examined in this study including % lymphocyte subpopulations and levels of serum neopterin and tryptophan metabolism ...found to alter, among other parameters, % CD3 + and CD4 + cells (Unal et ... See full document

... types of connective tissue: cartilage, subchondral bone and the synovial ...tissues in the hu- man body have one common cellular type: the fibroblast ...most of the ECM synthesis that is ... See full document

... aim of this study was to analyze the use of 12 single-nucleotide polymorphisms in genes ELAC2 , RNASEL and MSR1 as biomarkers for prostate cancer (PCa) detection and progression, ... See full document

... advance in RA treatment. However, remission or response is not achieved in all ...focused in the development of three different groups of mol- ecules: those against ... See full document

... alignment of the compounds to set field calculations was inside the binding ...software of Tripos ...were in training and test sets respectively) for external validation ...contained in ... See full document

... this study, SOD and GPx activities were higher in RA patients than in healthy individuals; however, these were not high enough to reduce oxidative damage to lipids and ...process ... See full document

... levels of ACPAs, and this finding may explain the association with less severe disease ...progression of joint damage has been related to levels of ACPAs, both in RA patients [39,40] ... See full document