In summary, the publications that were discussed herein give a comprehensive overview of the chemistry and applications of aza-Achmatowicz reactions. It has become evident from the examples that the aza-Achmatowicz products are indeed versatile building blocks that can be further functionalized using different modes of action. Furthermore the broad application of the reaction in a large number of natural product syntheses and in the synthesis of a variety of other molecules indicates its power and versatility. Finally, although various methods for the generation of optically pure aza-Achmatowicz substrates have been reported, only a few are catalytic.
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