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While the results presented are not entirely persuasive there is evidence that the 50 mg/mL dose may be beneficial when considering Group IV, TT. Given the shortcomings in the methods discussed above and the small size of our samples it seems that continued investigation with betahistine is warranted, especially in light of information from the National Ambulatory Medical Care survey. This survey showed that rates of otitis media visits in the ER significantly dropped from 1995-1996 to 2005-2006, but the proportion of visits that result in antibiotic prescriptions has remained constant around 80% of cases in the same time period suggesting alternative treatment options for otitis media should be further assessed (Grijalva et al., 2009).

REFERENCES

American Academy of Pediatrics Subcommittee on Management of Acute Otitis Media. (2004). Diagnosis and management of acute otitis media.

Pediatrics, 113(5), 1451–1465.

Arrang, J. M., Garbarg, M., Quach, T. T., Dam Trung TuongM, null, Yeramian, E., & Schwartz, J. C. (1985). Actions of betahistine at histamine receptors in the brain. European Journal of Pharmacology, 111(1), 73–84.

Arrang, J. M., Garbarg, M., & Schwartz, J. C. (1983). Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor. Nature, 302(5911), 832–837.

Azeem Sarwar, R. L. (2013). Magnetic Injection of Nanoparticles Into Rat Inner Ears at a Human Head Working Distance. IEEE Transactions on

Magnetics, 49(1), 440–452.

Bernstein, J. (1975). Biological mediators of inflammation im middle ear

effusions. The Annals of Otology, Rhinology, and Laryngology, 85(2 Suppl 25 Pt 2), 90–96.

Bernstein, J. M. (1996). Role of allergy in eustachian tube blockage and otitis media with effusion: a review. Otolaryngology--Head and Neck Surgery: Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 114(4), 562–568.

Casselbrant, M., & Mandel, E. (2003). Epidmiology. In Evidence Based Otitis Media (2nd ed., pp. 147–162). BC Decker Inc.

Connell, J. T. (1969). Quantitative intranasal pollen challenges: III. The priming effect in allergic rhinitis. Journal of Allergy, 43(1), 33–44.

Dowell, S. F., Marcy, S. M., Phillips, W. R., Gerber, M. A., & Schwartz, B. (1998). Otitis Media—Principles of Judicious Use of Antimicrobial Agents.

Pediatrics, 101(Supplement 1), 165–171.

Doyle, W. J., Boehm, S., & Skoner, D. P. (1990). Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy. The Journal of Allergy and Clinical Immunology, 86(6 Pt 1), 924– 935.

Draper, W. L. (1967). Secretory otitis media in children: A study of 540 children. The Laryngoscope, 77(4), 636–653.

Durland, W. F., Lane, A. P., Durland, K. W., Smith, T. L., Johnson, K. L., Prazma, J., & Pillsbury, H. C. (2000). Nitric oxide is a mediator of the late-phase response in an animal model of nasal allergy. Otolaryngology--Head and Neck Surgery: Official Journal of American Academy of Otolaryngology- Head and Neck Surgery, 122(5), 706–711.

Ebert, C. S., Pollock, H. W., Dubin, M. G., Scharer, S. S., Prazma, J., McQueen, C. T., & Pillsbury, H. C. (2002). Effect of intranasal histamine challenge on Eustachian tube function. International Journal of Pediatric

Otorhinolaryngology, 63(3), 189–198.

Ebert, C. S., Rose, A. S., Patel, M. R., Hardy, S. M., Kandimalla, E. R., Agrawal, S., … Pillsbury, H. C. (2006). The role of immunomodulatory

oligonucleotides in prevention of OVA-induced Eustachian tube

dysfunction. International Journal of Pediatric Otorhinolaryngology, 70(12), 2019–2026.

Fadal, R. (1993). IgE-mediated hypersensitivity reactions. Otolaryngology--Head and Neck Surgery  : Official Journal of American Academy of

Otolaryngology-Head and Neck Surgery, 109(3 Pt 2), 565–578.

Fireman, P. (1997). Otitis media and eustachian tube dysfunction: connection to allergic rhinitis. The Journal of Allergy and Clinical Immunology, 99(2), S787–797.

Flisberg, K., Ingelstedt, S., & Ortegren, U. (1963). The valve and “locking” mechanisms of the eustachian tube. Acta Oto-Laryngologica. Supplementum, 182, 57–68.

Franz, B., & Anderson, C. R. (2007). The effect of the sympathetic and sensory nervous system on active eustachian tube function in the rat. Acta Oto- Laryngologica, 127(3), 265–272.

Franz, B., Shafton, A. D., & Anderson, C. R. (2011). Topical application of betahistine improves eustachian tube function in an animal model. Acta Oto-Laryngologica, 131(11), 1155–1159.

Gates, G. A., Klein, J. O., Lim, D. J., Mogi, G., Ogra, P. L., Pararella, M. M., … Tos, M. (2002). Recent advances in otitis media. 1. Definitions,

terminology, and classification of otitis media. The Annals of Otology, Rhinology & Laryngology. Supplement, 188, 8–18.

Gouma, P., Mallis, A., Daniilidis, V., Gouveris, H., Armenakis, N., & Naxakis, S. (2011). Behavioral trends in young children with conductive hearing loss: a case-control study. European Archives of Oto-Rhino-Laryngology: Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 268(1), 63–66.

Grijalva, C. G., Nuorti, J. P., & Griffin, M. R. (2009). Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings. JAMA, 302(7), 758–766.

Hancock, A. A. (2006). The challenge of drug discovery of a GPCR target: analysis of preclinical pharmacology of histamine H3 antagonists/inverse agonists. Biochemical Pharmacology, 71(8), 1103–1113.

Hancock, A. A., Esbenshade, T. A., Krueger, K. M., & Yao, B. B. (2003). Genetic and pharmacological aspects of histamine H3 receptor heterogeneity. Life Sciences, 73(24), 3043–3072.

Hardy, S. M., Heavner, S. B., White, D. R., Mcqueen, C. T., Prazma, J., & Pillsbury, H. C. (2001). Late-phase allergy and eustachian tube

dysfunction. Otolaryngology - Head and Neck Surgery, 125(4), 339–345. Hardy, S. M., Heavner, S. B., White, D. R., McQueen, C. T., Prazma, J., &

Pillsbury, H. C. (2001). Late-phase allergy and eustachian tube

dysfunction. Otolaryngology--Head and Neck Surgery: Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 125(4), 339–345.

Hilberg, O., Grymer, L. F., & Pedersen, O. F. (1995). Nasal histamine challenge in nonallergic and allergic subjects evaluated by acoustic rhinometry. Allergy, 50(2), 166–173.

Hills, B. A. (2002). Surface tension versus straight adhesion in the Eustachian tube. Otology & Neurotology: Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 23(4), 620; author reply 621.

Holborow, C. (1970). Eustachian tubal function. Changes in anatomy and

function with age and the relationship of these changes to aural pathology. Archives of Otolaryngology (Chicago, Ill.: 1960), 92(6), 624–626.

Holborow, C. (1975). Eustachian tubal function: changes throughout childhood and neuro-muscular control. The Journal of Laryngology and Otology, 89(1), 47–55.

Howarth, P. H., Salagean, M., & Dokic, D. (2000). Allergic rhinitis: not purely a histamine-related disease. Allergy, 55 Suppl 64, 7–16.

Labadie, R. F., Jewett, B. S., Hart, C. F., Prazma, J., & Pillsbury, H. C. (1999). Allergy increases susceptibility to otitis media with effusion in a rat model. Second place--Resident Clinical Science Award 1998. Otolaryngology-- Head and Neck Surgery: Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 121(6), 687–692.

Lieberman, P. (2011). The basics of histamine biology. Annals of Allergy, Asthma & Immunology: Official Publication of the American College of Allergy, Asthma, & Immunology, 106(2 Suppl), S2–5.

Mann, W., Jonas, I., & Münker, G. (1979). Growth influence on tubal function. Acta Oto-Laryngologica, 87(5-6), 451–457.

Miller, G. F. (1965). Eustachian Tubal Function in Normal and Diseased Ears. Archives of Otolaryngology (Chicago, Ill.: 1960), 81, 41–48.

Monroe, E. W., Daly, A. F., & Shalhoub, R. F. (1997). Appraisal of the validity of histamine-induced wheal and flare to predict the clinical efficacy of

antihistamines. The Journal of Allergy and Clinical Immunology, 99(2), S798–806.

Mygind, N., & Naclerio, R. M. (1993). Allergic and Non-Allergic Rhinitis: Clinical Aspects (1st edition). Saunders.

Naclerio, R. M., Proud, D., Togias, A. G., Adkinson, N. F., Meyers, D. A., Kagey- Sobotka, A., … Lichtenstein, L. M. (1985). Inflammatory Mediators in Late Antigen-Induced Rhinitis. New England Journal of Medicine, 313(2), 65– 70.

Nakaya, M., Fukushima, Y., Takeuchi, N., & Kaga, K. (2005). Nasal allergic response mediated by histamine H3 receptors in murine allergic rhinitis.

Nguyen, T., Shapiro, D. A., George, S. R., Setola, V., Lee, D. K., Cheng, R., … O’Dowd, B. F. (2001). Discovery of a Novel Member of the Histamine Receptor Family. Molecular Pharmacology, 59(3), 427–433.

Oates, J. A., Wood, A. J., & Naclerio, R. M. (1991). Allergic Rhinitis. The New England Journal of Medicine, 325(12), 860–869.

Pollock, H. W., Ebert, C. S., Dubin, M. G., White, D. R., Prazma, J., & Pillsbury III, H. C. (2002). The role of soluble interleukin-4 receptor and interleukin-5 antibody in preventing late-phase allergy-induced eustachian tube

dysfunction. Otolaryngology - Head and Neck Surgery, 127(3), 169–176. Rajakulasingam, K., Polosa, R., Lau, L. C., Church, M. K., Holgate, S. T., &

Howarth, P. H. (1993). Comparative nasal effects of bradykinin and histamine: influence on nasal airways resistance and plasma protein exudation. Thorax, 48(4), 324–329.

Rascol, O., Hain, T. C., Brefel, C., Benazet, M., Clanet, M., & Montastruc, J. L. (1995). Antivertigo medications and drug-induced vertigo. A

pharmacological review. Drugs, 50(5), 777–791.

Sade, J. (1966). Middle ear mucosa. Archives of Otolaryngology (Chicago, Ill.: 1960), 84(2), 137–143.

Shekelle, P., Takata, G., Chan, L. S., Mangione-Smith, R., Corley, P. M., Morphew, T., & Morton, S. (2002). Diagnosis, natural history, and late effects of otitis media with effusion. Evidence Report/Technology Assessment (Summary), (55), 1–5.

Siddiq, S., Grainger, J., & Prentice, P. (2014). The diagnosis and management of acute otitis media: American Academy of Pediatrics Guidelines 2013. Archives of Disease in Childhood. Education and Practice Edition. Simpson, S. A., Lewis, R., van der Voort, J., & Butler, C. C. (2011). Oral or

topical nasal steroids for hearing loss associated with otitis media with effusion in children. The Cochrane Database of Systematic Reviews, (5), CD001935.

Skoner, D. P. (2001). Allergic rhinitis: Definition, epidemiology, pathophysiology, detection, and diagnosis. Journal of Allergy and Clinical Immunology, 108(1, Supplement), S2–S8.

Sobol, S. E., Taha, R., Schloss, M. D., Mazer, B. D., Manoukian, J. J., Tewfik, T. L., & Hamid, Q. (2002). TH2 cytokine expression in atopic children with otitis media with effusion. Journal of Allergy and Clinical Immunology, 110(1), 125–130.

Suzuki, S., Takeuchi, K., & Majima, Y. (2008). Localization and function of histamine H3 receptor in the nasal mucosa. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology, 38(9), 1476–1482.

Takahashi, H., Hayashi, M., Sato, H., & Honjo, I. (1989). Primary deficits in eustachian tube function in patients with otitis media with effusion. Archives of Otolaryngology--Head & Neck Surgery, 115(5), 581–584. Taylor-Clark, T., Sodha, R., Warner, B., & Foreman, J. (2005). Histamine

receptors that influence blockage of the normal human nasal airway. British Journal of Pharmacology, 144(6), 867–874.

Tomooka, L. T., Murphy, C., & Davidson, T. M. (2000). Clinical Study and Literature Review of Nasal Irrigation. The Laryngoscope, 110(7), 1189– 1193.

Van Zon, A., van der Heijden, G. J., van Dongen, T. M. A., Burton, M. J., & Schilder, A. G. M. (2012). Antibiotics for otitis media with effusion in children. The Cochrane Database of Systematic Reviews, 9, CD009163. West, R. E., Zweig, A., Shih, N. Y., Siegel, M. I., Egan, R. W., & Clark, M. A.

(1990). Identification of two H3-histamine receptor subtypes. Molecular Pharmacology, 38(5), 610–613.

White, D. R., Heavner, S. B., Hardy, S. M., & Prazma, J. (2002).

Gastroesophageal Reflux and Eustachian Tube Dysfunction in an Animal Model. The Laryngoscope, 112(6), 955–961.

Wood-Baker, R., Lau, L., & Howarth, P. H. (1996). Histamine and the nasal vasculature: the influence of H1 and H2-histamine receptor antagonism. Clinical Otolaryngology and Allied Sciences, 21(4), 348–352.

CURRICULUM VITAE JAMES DAVID WILSON

[email protected] Born 1989 Permanent Address: 901 Mill Road Goldsboro, NC 27534 Cell: 919-920-6594

EDUCATION Boston University School of Medicine

M.S. Candidate, Medical Sciences Expected: May 2015

University of North Carolina at Chapel Hill B.S. Biology, B.A. Chemistry

Cognitive Science Minor May 2012

CLINICAL AND LAB EXPERIENCE

UNC School of Medicine; Department of Otolaryngology/HNS Research Assistant

Chapel Hill, NC July 2014-Present

Central Dermatology Center.

Medical Office Assistant Chapel Hill, NC

October 2012-July 2013

UNC McAllister Heart Institute; Runge Lab Research Assistant

Chapel Hill, NC May 2011-May 2012

UNC Hospitals Emergency Department Aide

Chapel Hill, NC

January 2011-May 2011

In document REGLAMENTO DE RÉGIMEN INTERIOR (página 40-43)

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