6. RESULTADOS OBTENIDOS
6.3 ANÁLISIS DE REFERENTES HISTÓRICOS Y MULTITEMPORAL
(1) Statistisches Bundesamt. Statistisches Jahrbuch 2006 für die Bundesrepublik Deutsch- land. 4 A.D.
(2) Ruchholtz S, Nast-Kolb D, Waydhas C, Schweiberer L. [The injury pattern in poly- trauma. Value of information regarding accident process in clinical acute manage- ment]. Unfallchirurg 1996; 99(9):633-641.
(3) Schweiberer L, Nast-Kolb D, Duswald KH, Waydhas C, Muller K. [Polytrauma-- treatment by the staged diagnostic and therapeutic plan]. Unfallchirurg 1987; 90(12):529-538.
(4) Keel M, Trentz O. Pathophysiology of polytrauma. Injury 2005; 36(6):691-709. (5) Ruchholtz S, Nast-Kolb D, Waydhas C, Betz P, Schweiberer L. [Early mortality in
polytrauma. A critical analysis of preventable errors]. Unfallchirurg 1994; 97(6):285- 291.
(6) Nast-Kolb D, Waydhas C, Kastl S, Duswald KH, Schweiberer L. [The role of an ab- dominal injury in follow-up of polytrauma patients]. Chirurg 1993; 64(7):552-559. (7) Sauaia A, Moore FA, Moore EE, Norris JM, Lezotte DC, Hamman RF. Multiple or-
gan failure can be predicted as early as 12 hours after injury. J Trauma 1998; 45(2):291-301.
(8) Adrie C, Adib-Conquy M, Laurent I, Monchi M, Vinsonneau C, Fitting C et al. Suc- cessful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-like" syndrome. Circulation 2002; 106(5):562-568.
(9) Alho A, Lahdensuu M, Jaattela A, Avikainen V, Karaharju E, Lepisto P et al. Bio- chemical quantification of blunt injuries. Eur J Intensive Care Med 1975; 1(2):61-64. (10) Ayala A, Chung CS, Grutkoski PS, Song GY. Mechanisms of immune resolution. Crit
Care Med 2003; 31(8 Suppl):S558-S571.
(11) Baldwin AS, Jr. The NF-kappa B and I kappa B proteins: new discoveries and in- sights. Annu Rev Immunol 1996; 14:649-683.
(12) Ward PA, Lentsch AB. Endogenous regulation of the acute inflammatory response. Mol Cell Biochem 2002; 234-235(1-2):225-228.
(13) Pastores SM, Thakkar A, Gennis P, Katz DP, Kvetan V. Posttraumatic multiple-organ dysfunction syndrome: role of mediators in systemic inflammation and subsequent or- gan failure. Acad Emerg Med 1996; 3(6):611-622.
(14) Plank LD, Hill GL. Sequential metabolic changes following induction of systemic inflammatory response in patients with severe sepsis or major blunt trauma. World J Surg 2000; 24(6):630-638.
(15) Sauaia A, Moore FA, Moore EE, Haenel JB, Read RA, Lezotte DC. Early predictors of postinjury multiple organ failure. Arch Surg 1994; 129(1):39-45.
(16) Schinkel C, Zimmer S, Kremer JP, Walz A, Rordorf-Adam C, Henckel vD et al. Comparative analysis of transcription and protein release of the inflammatory cyto- kines interleukin-1 beta (IL-1 beta) and interleukin-8 (IL-8) following major burn and mechanical trauma. Shock 1995; 4(4):241-246.
(17) Moore FA, Moore EE, Read RA. Postinjury multiple organ failure: role of extratho- racic injury and sepsis in adult respiratory distress syndrome. New Horiz 1993; 1(4):538-549.
(18) Moore FA, Moore EE. Evolving concepts in the pathogenesis of postinjury multiple organ failure. Surg Clin North Am 1995; 75(2):257-277.
(19) Gumanenko EK, Nemchenko NS, Goncharov AV, Pashkovskii EV. [Pathogenetical features of the acute period of traumatic disease. Traumatic shock as a special mani- festation of the acute period]. Vestn Khir Im I I Grek 2004; 163(6):52-56.
(20) Ertel W, Keel M, Marty D, Hoop R, Safret A, Stocker R et al. [Significance of syste- mic inflammation in 1,278 trauma patients]. Unfallchirurg 1998; 101(7):520-526. (21) Moore FA, Moore EE, Read RA. Postinjury multiple organ failure: role of extratho-
racic injury and sepsis in adult respiratory distress syndrome. New Horiz 1993; 1(4):538-549.
(22) Beal AL, Cerra FB. Multiple organ failure syndrome in the 1990s. Systemic inflam- matory response and organ dysfunction. JAMA 1994; 271(3):226-233.
(23) Moore FA, Moore EE. Evolving concepts in the pathogenesis of postinjury multiple organ failure. Surg Clin North Am 1995; 75(2):257-277.
(24) Deitch EA, Goodman ER. Prevention of multiple organ failure. Surg Clin North Am 1999; 79(6):1471-1488.
(25) Ertel W, Trentz O. [Polytrauma and multi-organ failure syndrome. Definition-- pathophysiology--therapy]. Zentralbl Chir 1994; 119(3):159-167.
(26) Nast-Kolb D, Aufmkolk M, Rucholtz S, Obertacke U, Waydhas C. Multiple organ failure still a major cause of morbidity but not mortality in blunt multiple trauma. J Trauma 2001; 51(5):835-841.
(27) Mannick JA, Rodrick ML, Lederer JA. The immunologic response to injury. J Am Coll Surg 2001; 193(3):237-244.
(28) Faist E, Baue AE, Dittmer H, Heberer G. Multiple organ failure in polytrauma pa- tients. J Trauma 1983; 23(9):775-787.
(29) Moore FA, Sauaia A, Moore EE, Haenel JB, Burch JM, Lezotte DC. Postinjury mul- tiple organ failure: a bimodal phenomenon. J Trauma 1996; 40(4):501-510.
(30) Mannick JA, Rodrick ML, Lederer JA. The immunologic response to injury. J Am Coll Surg 2001; 193(3):237-244.
(32) Schinkel C, Zimmer S, Kremer JP, Walz A, Rordorf-Adam C, Henckel vD et al. Comparative analysis of transcription and protein release of the inflammatory cyto- kines interleukin-1 beta (IL-1 beta) and interleukin-8 (IL-8) following major burn and mechanical trauma. Shock 1995; 4(4):241-246.
(33) Pastores SM, Thakkar A, Gennis P, Katz DP, Kvetan V. Posttraumatic multiple-organ dysfunction syndrome: role of mediators in systemic inflammation and subsequent or- gan failure. Acad Emerg Med 1996; 3(6):611-622.
(34) Plank LD, Hill GL. Sequential metabolic changes following induction of systemic inflammatory response in patients with severe sepsis or major blunt trauma. World J Surg 2000; 24(6):630-638.
(35) Sauaia A, Moore FA, Moore EE, Haenel JB, Read RA, Lezotte DC. Early predictors of postinjury multiple organ failure. Arch Surg 1994; 129(1):39-45.
(36) Schinkel C, Zimmer S, Kremer JP, Walz A, Rordorf-Adam C, Henckel vD et al. Comparative analysis of transcription and protein release of the inflammatory cyto- kines interleukin-1 beta (IL-1 beta) and interleukin-8 (IL-8) following major burn and mechanical trauma. Shock 1995; 4(4):241-246.
(37) Winet H, Hsieh A, Bao JY. Approaches to study of ischemia in bone. J Biomed Mater Res 1998; 43(4):410-421.
(38) Robinson CM. Current concepts of respiratory insufficiency syndromes after fracture. J Bone Joint Surg Br 2001; 83(6):781-791.
(39) Antrum RM, Solomkin JS. Complement activation products and monocyte migratory function in trauma. Curr Surg 1985; 42(4):301-303.
(40) Guo RF, Ward PA. Role of C5a in inflammatory responses. Annu Rev Immunol 2005; 23:821-852.
(41) Schlag G, Redl H. Mediators of injury and inflammation. World J Surg 1996; 20(4):406-410.
(42) Armstead VE, Opentanova IL, Minchenko AG, Lefer AM. Tissue factor expression in vital organs during murine traumatic shock: role of transcription factors AP-1 and NF- kappaB. Anesthesiology 1999; 91(6):1844-1852.
(43) Ballard-Croft C, Maass DL, Sikes P, White J, Horton J. Activation of stress-
responsive pathways by the sympathetic nervous system in burn trauma. Shock 2002; 18(1):38-45.
(44) Bell MJ, Kochanek PM, Doughty LA, Carcillo JA, Adelson PD, Clark RS et al. Inter- leukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. J Neurotrauma 1997; 14(7):451-457.
(45) Bhaumik G, Srivastava KK, Selvamurthy W, Purkayastha SS. The role of free radicals in cold injuries. Int J Biometeorol 1995; 38(4):171-175.
(46) Biffl WL, Moore EE, Moore FA, Peterson VM. Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation? Ann Surg 1996; 224(5):647-664.
(47) Carsin H, Assicot M, Feger F, Roy O, Pennacino I, Le Bever H et al. Evolution and significance of circulating procalcitonin levels compared with IL-6, TNF alpha and endotoxin levels early after thermal injury. Burns 1997; 23(3):218-224.
(48) Sen R, Baltimore D. Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell 1986; 47(6):921-928.
(49) Cioffi WG, Burleson DG, Pruitt BA, Jr. Leukocyte responses to injury. Arch Surg 1993; 128(11):1260-1267.
(50) van den BR, Haenen GR, van den BH, Bast A. Transcription factor NF-kappaB as a potential biomarker for oxidative stress. Br J Nutr 2001; 86 Suppl 1:S121-S127. (51) Rose S, Marzi I. [Pathophysiology of polytrauma]. Zentralbl Chir 1996; 121(11):896-
913.
(52) Hack CE, Nuijens JH, Strack van Schijndel RJ, Abbink JJ, Eerenberg AJ, Thijs LG. A model for the interplay of inflammatory mediators in sepsis--a study in 48 patients. In- tensive Care Med 1990; 16 Suppl 3:S187-S191.
(53) Ege T, Us MH, Sungun M, Duran E. Cytokine response in lower extremity ischae- mia/reperfusion. J Int Med Res 2004; 32(2):124-131.
(54) Ege T, Us MH, Sungun M, Duran E. Cytokine response in lower extremity ischae- mia/reperfusion. J Int Med Res 2004; 32(2):124-131.
(55) Kong SE, Blennerhassett LR, Heel KA, McCauley RD, Hall JC. Ischaemia- reperfusion injury to the intestine. Aust N Z J Surg 1998; 68(8):554-561.
(56) Kupatt C, Habazettl H, Goedecke A, Wolf DA, Zahler S, Boekstegers P et al. Tumor necrosis factor-alpha contributes to ischemia- and reperfusion-induced endothelial ac- tivation in isolated hearts. Circ Res 1999; 84(4):392-400.
(57) Kupiec-Weglinski JW, Busuttil RW. Ischemia and reperfusion injury in liver trans- plantation. Transplant Proc 2005; 37(4):1653-1656.
(58) Lai EW, Toledo-Pereyra LH, Walsh J, Lopez-Neblina F, Anaya-Prado R. The role of MAP kinases in trauma and ischemia-reperfusion. J Invest Surg 2004; 17(1):45-53. (59) Rose S, Marzi I. Mediators in polytrauma--pathophysiological significance and clini-
cal relevance. Langenbecks Arch Surg 1998; 383(3-4):199-208.
(60) Taylor BS, Alarcon LH, Billiar TR. Inducible nitric oxide synthase in the liver: regula- tion and function. Biochemistry (Mosc ) 1998; 63(7):766-781.
(61) Biberthaler P, Luchting B, Massberg S, Teupser D, Langer S, Leiderer R et al. Ische- mia at 4 degrees C: a novel mouse model to investigate the effect of hypothermia on postischemic hepatic microcirculatory injury. Res Exp Med (Berl) 2001; 200(2):93- 105.
(62) Haljamae H. The pathophysiology of shock. Acta Anaesthesiol Scand Suppl 1993; 98:3-6.
(63) Schlag G, Redl H. Lung in shock--posttraumatic lung failure (organ failure)--MOFS. Prog Clin Biol Res 1989; 308:3-16.
(64) Suter PM, Morel DR, Laverriere MC. [Post-traumatic pulmonary insufficiency: thera- peutic measures]. Schweiz Med Wochenschr 1989; 119(11):364-368.
(65) Nerlich AG, Nerlich ML, Joachim H, Muller PK. Biochemical changes in parenchy- mal lung tissue associated with posttraumatic respiratory failure. Eur J Clin Invest 1984; 14(3):190-198.
(66) Stene JK. Renal failure in the trauma patient. Crit Care Clin 1990; 6(1):111-119. (67) Whelton A. Post-traumatic acute renal failure. Bull N Y Acad Med 1979; 55(2):150-
162.
(68) Vivino G, Antonelli M, Moro ML, Cottini F, Conti G, Bufi M et al. Risk factors for acute renal failure in trauma patients. Intensive Care Med 1998; 24(8):808-814. (69) Stene JK. Renal failure in the trauma patient. Crit Care Clin 1990; 6(1):111-119. (70) Whelton A. Post-traumatic acute renal failure. Bull N Y Acad Med 1979; 55(2):150-
162.
(71) Eknoyan G. Emergence of the concept of acute renal failure. Am J Nephrol 2002; 22(2-3):225-230.
(72) O'Keefe GE, Maier RV. New regimens in the management of posttraumatic respira- tory failure. Curr Opin Pulm Med 1997; 3(3):227-233.
(73) Suter PM, Morel DR, Laverriere MC. [Post-traumatic pulmonary insufficiency: thera- peutic measures]. Schweiz Med Wochenschr 1989; 119(11):364-368.
(74) Nerlich AG, Nerlich ML, Joachim H, Muller PK. Biochemical changes in parenchy- mal lung tissue associated with posttraumatic respiratory failure. Eur J Clin Invest 1984; 14(3):190-198.
(75) Wong HR, Wispe JR. The stress response and the lung. Am J Physiol 1997; 273(1 Pt 1):L1-L9.
(76) Hassoun HT, Kone BC, Mercer DW, Moody FG, Weisbrodt NW, Moore FA. Post- injury multiple organ failure: the role of the gut. Shock 2001; 15(1):1-10.
(77) Hierholzer C, Kalff JC, Billiar TR, Bauer AJ, Tweardy DJ, Harbrecht BG. Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol 2004; 286(2):G225-G233.
(78) Kong SE, Blennerhassett LR, Heel KA, McCauley RD, Hall JC. Ischaemia- reperfusion injury to the intestine. Aust N Z J Surg 1998; 68(8):554-561.
(79) Kuebler JF, Toth B, Rue LW, Bland KI, Chaudry IH. Differential alterations in intes- tinal permeability after trauma-hemorrhage. J Surg Res 2003; 112(2):198-204.
(80) Hassoun HT, Kone BC, Mercer DW, Moody FG, Weisbrodt NW, Moore FA. Post- injury multiple organ failure: the role of the gut. Shock 2001; 15(1):1-10.
(81) Henrion J. Ischemia/reperfusion injury of the liver: pathophysiologic hypotheses and potential relevance to human hypoxic hepatitis. Acta Gastroenterol Belg 2000; 63(4):336-347.
(82) Hill AG, Hill GL. Metabolic response to severe injury. Br J Surg 1998; 85(7):884-890. (83) Klein D, Einspanier R, Bolder U, Jeschke MG. Differences in the hepatic signal tran-
scription pathway and cytokine expression between thermal injury and sepsis. Shock 2003; 20(6):536-543.
(84) Laudanski K, Wyczechowska D. Monocyte-related immunopathologies in trauma pa- tients. Arch Immunol Ther Exp (Warsz ) 2005; 53(4):321-328.
(85) Lederer JA, Rodrick ML, Mannick JA. The effects of injury on the adaptive immune response. Shock 1999; 11(3):153-159.
(86) Zedler S, Bone RC, Baue AE, von Donnersmarck GH, Faist E. T-cell reactivity and its predictive role in immunosuppression after burns. Crit Care Med 1999; 27(1):66-72. (87) Alexander JW, Stinnett JD, Ogle CK, Ogle JD, Morris MJ. A comparison of immu-
nologic profiles and their influence on bacteremia in surgical patients with a high risk of infection. Surgery 1979; 86(1):94-104.
(88) Rose S, Marzi I. Mediators in polytrauma--pathophysiological significance and clini- cal relevance. Langenbecks Arch Surg 1998; 383(3-4):199-208.
(89) Szebeni J, Baranyi L, Savay S, Gotze O, Alving CR, Bunger R et al. Complement ac- tivation during hemorrhagic shock and resuscitation in swine. Shock 2003; 20(4):347- 355.
(90) Zwacka RM, Zhang Y, Halldorson J, Schlossberg H, Dudus L, Engelhardt JF. CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver. J Clin Invest 1997; 100(2):279-289.
(91) Hietbrink F, Oudijk EJ, Braams R, Koenderman L, Leenen L. Aberrant regulation of polymorphonuclear phagocyte responsiveness in multitrauma patients. Shock 2006; 26(6):558-564.
(92) Hierholzer C, Billiar TR, Tweardy DJ, Harbrecht B. Reduced hepatic transcription factor activation and expression of IL-6 and ICAM-1 after hemorrhage by NO scav- enging. Arch Orthop Trauma Surg 2003; 123(2-3):55-59.
(93) Lederer JA, Liou JS, Kim S, Rice N, Lichtman AH. Regulation of NF-kappa B activa- tion in T helper 1 and T helper 2 cells. J Immunol 1996; 156(1):56-63.
(94) Fosse E, Mollnes TE, Aasen AO, Trumpy JH, Stokke T. Complement activation fol- lowing multiple injuries. Acta Chir Scand 1987; 153(5-6):325-330.
(95) Hill J, Lindsay TF, Ortiz F, Yeh CG, Hechtman HB, Moore FD, Jr. Soluble comple- ment receptor type 1 ameliorates the local and remote organ injury after intestinal ischemia-reperfusion in the rat. J Immunol 1992; 149(5):1723-1728.
(96) Lindsay TF, Hill J, Ortiz F, Rudolph A, Valeri CR, Hechtman HB et al. Blockade of complement activation prevents local and pulmonary albumin leak after lower torso ischemia-reperfusion. Ann Surg 1992; 216(6):677-683.
(97) Hildebrand F, Pape HC, Krettek C. [The importance of cytokines in the posttraumatic inflammatory reaction.]. Unfallchirurg 2005; 108(10):793-803.
(98) Hietbrink F, Oudijk EJ, Braams R, Koenderman L, Leenen L. Aberrant regulation of polymorphonuclear phagocyte responsiveness in multitrauma patients. Shock 2006; 26(6):558-564.
(99) Lederer JA, Rodrick ML, Mannick JA. The effects of injury on the adaptive immune response. Shock 1999; 11(3):153-159.
(100) Baue AE, Durham R, Faist E. Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle? Shock 1998; 10(2):79-89.
(101) Ding WX, Yin XM. Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury. J Cell Mol Med 2004; 8(4):445-454.
(102) Cioffi WG, Burleson DG, Pruitt BA, Jr. Leukocyte responses to injury. Arch Surg 1993; 128(11):1260-1267.
(103) van den BR, Haenen GR, van den BH, Bast A. Transcription factor NF-kappaB as a potential biomarker for oxidative stress. Br J Nutr 2001; 86 Suppl 1:S121-S127. (104) Knoblach SM, Faden AI. Interleukin-10 improves outcome and alters proinflamma-
tory cytokine expression after experimental traumatic brain injury. Exp Neurol 1998; 153(1):143-151.
(105) Ballard-Croft C, Maass DL, Sikes P, White J, Horton J. Activation of stress-
responsive pathways by the sympathetic nervous system in burn trauma. Shock 2002; 18(1):38-45.
(106) Bell MJ, Kochanek PM, Doughty LA, Carcillo JA, Adelson PD, Clark RS et al. Inter- leukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. J Neurotrauma 1997; 14(7):451-457.
(107) Bhaumik G, Srivastava KK, Selvamurthy W, Purkayastha SS. The role of free radicals in cold injuries. Int J Biometeorol 1995; 38(4):171-175.
(108) Biffl WL, Moore EE, Moore FA, Peterson VM. Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation? Ann Surg 1996; 224(5):647-664. (109) Carsin H, Assicot M, Feger F, Roy O, Pennacino I, Le Bever H et al. Evolution and
significance of circulating procalcitonin levels compared with IL-6, TNF alpha and endotoxin levels early after thermal injury. Burns 1997; 23(3):218-224.
(110) Sen R, Baltimore D. Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell 1986; 47(6):921-928.
(111) Islam KN, Mendelson CR. Potential role of nuclear factor kappaB and reactive oxygen species in cAMP and cytokine regulation of surfactant protein-A gene expression in lung type II cells. Mol Endocrinol 2002; 16(6):1428-1440.
(112) Jeschke MG, Low JF, Spies M, Vita R, Hawkins HK, Herndon DN et al. Cell prolif- eration, apoptosis, NF-kappaB expression, enzyme, protein, and weight changes in livers of burned rats. Am J Physiol Gastrointest Liver Physiol 2001; 280(6):G1314- G1320.
(113) Kaltschmidt C, Kaltschmidt B, Henkel T, Stockinger H, Baeuerle PA. Selective rec- ognition of the activated form of transcription factor NF-kappa B by a monoclonal an- tibody. Biol Chem Hoppe Seyler 1995; 376(1):9-16.
(114) Kim GM, Xu J, Xu J, Song SK, Yan P, Ku G et al. Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis pro- tein 2 expression, and functional recovery after traumatic spinal cord injury. J Neuro- sci 2001; 21(17):6617-6625.
(115) Kim PK, Deutschman CS. Inflammatory responses and mediators. Surg Clin North Am 2000; 80(3):885-894.
(116) Schulze-Luehrmann J, Ghosh S. Antigen-receptor signaling to nuclear factor kappa B. Immunity 2006; 25(5):701-715.
(117) Sen R, Baltimore D. Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell 1986; 47(6):921-928.
(118) Traenckner EB, Wilk S, Baeuerle PA. A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B. EMBO J 1994; 13(22):5433-5441.
(119) van den BR, Haenen GR, van den BH, Bast A. Transcription factor NF-kappaB as a potential biomarker for oxidative stress. Br J Nutr 2001; 86 Suppl 1:S121-S127. (120) Islam KN, Mendelson CR. Potential role of nuclear factor kappaB and reactive oxygen
species in cAMP and cytokine regulation of surfactant protein-A gene expression in lung type II cells. Mol Endocrinol 2002; 16(6):1428-1440.
(121) Jeschke MG, Low JF, Spies M, Vita R, Hawkins HK, Herndon DN et al. Cell prolif- eration, apoptosis, NF-kappaB expression, enzyme, protein, and weight changes in livers of burned rats. Am J Physiol Gastrointest Liver Physiol 2001; 280(6):G1314- G1320.
(122) Kaltschmidt C, Kaltschmidt B, Henkel T, Stockinger H, Baeuerle PA. Selective rec- ognition of the activated form of transcription factor NF-kappa B by a monoclonal an- tibody. Biol Chem Hoppe Seyler 1995; 376(1):9-16.
(123) Kim GM, Xu J, Xu J, Song SK, Yan P, Ku G et al. Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis pro-
tein 2 expression, and functional recovery after traumatic spinal cord injury. J Neuro- sci 2001; 21(17):6617-6625.
(124) Fan C, Li Q, Zhang Y, Liu X, Luo M, Abbott D et al. IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation. J Clin Invest 2004; 113(5):746-755.
(125) King DJ, Bassett SE, Li X, Fennewald SA, Herzog NK, Luxon BA et al. Combinato- rial selection and binding of phosphorothioate aptamers targeting human NF-kappa B RelA(p65) and p50. Biochemistry 2002; 41(30):9696-9706.
(126) Mayo MW, Norris JL, Baldwin AS. Ras regulation of NF-kappa B and apoptosis. Methods Enzymol 2001; 333:73-87.
(127) Ward PA, Lentsch AB. Endogenous regulation of the acute inflammatory response. Mol Cell Biochem 2002; 234-235(1-2):225-228.
(128) Burke JR. Targeting I kappa B kinase for the treatment of inflammatory and other dis- orders. Curr Opin Drug Discov Devel 2003; 6(5):720-728.
(129) Fan C, Li Q, Zhang Y, Liu X, Luo M, Abbott D et al. IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation. J Clin Invest 2004; 113(5):746-755.
(130) Baeuerle PA, Henkel T. Function and activation of NF-kappa B in the immune sys- tem. Annu Rev Immunol 1994; 12:141-179.
(131) Finco TS, Baldwin AS. Mechanistic aspects of NF-kappa B regulation: the emerging role of phosphorylation and proteolysis. Immunity 1995; 3(3):263-272.
(132) Nichols TC. NF-kappaB and reperfusion injury. Drug News Perspect 2004; 17(2):99- 104.
(133) Wullaert A, Heyninck K, Beyaert R. Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes. Biochem Pharmacol 2006;
72(9):1090-1101.
(134) Gilston V, Jones HW, Soo CC, Coumbe A, Blades S, Kaltschmidt C et al. NF-kappa B activation in human knee-joint synovial tissue during the early stage of joint inflam- mation. Biochem Soc Trans 1997; 25(3):518S.
(135) Schulze-Luehrmann J, Ghosh S. Antigen-receptor signaling to nuclear factor kappa B. Immunity 2006; 25(5):701-715.
(136) Yamamoto Y, Gaynor RB. Role of the NF-kappaB pathway in the pathogenesis of human disease states. Curr Mol Med 2001; 1(3):287-296.
(137) Drent M, van den BR, Haenen GR, van den BH, Wouters EF, Bast A. NF-kappaB activation in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2001; 18(1):50-56. (138) Yamamoto K. [The activation and function of p53 in cellular response to environ-