3. Desarrollo de la propuesta
3.3. Desarrollo de la propuesta didáctica
3.3.4. Bloque 4: mujeres en la literatura del siglo XIX Rosalía de Castro
There are several basic and practical implications of the current work. It has been noted
previously that many asexual lineages derived from sexual populations (i.e.,
parthenogens) are evolutionarily short-lived (e.g. Haigh 1978; Maynard Smith 1982). As noted in Ch. III, models of Muller‘s ratchet were initially proposed to explain an
advantage of sexual (or a disadvantage of asexual) reproduction. The current results, in
accordance with previous theory (Andre and Godelle 2005) and simulations (Gerrish et
mutations, may be influential in determining the ultimate fate of an asexual population.
In contrast, recombination in sexual populations may prevent mutator hitchhiking, thus a
sexual population might rarely be threatened by a high mutation rate. It is important to
note that many populations that are considered asexual, including natural populations of
E. coli, do undergo some form recombination. It remains an open question as to the level of recombination necessary to prevent recurrent mutator hitchhiking.
It has been observed that RNA viruses have exceptionally high genomic mutation rates
relative to DNA based microbes (Drake et al. 1998; Drake and Holland 1999). With such
a high basal genomic mutation rate, a feasible route to treating viral infections might be
the induction of a mutation rate that surpasses a critical threshold. Current mutation-
based approaches of treating viral infections involve the application of mutagens to
increase the genomic mutation rate of a virus (Loeb et al. 1999; Crotty et al. 2002;
Vignuzzi et al. 2005b; Graci et al. 2007; Graci et al. 2008). However, viruses are likely
to evolve resistance to mutagens in the same manner that they can evolve resistance to
many other antiviral drugs, often through loss-of-function mutations (Springman et al.
2010). Indeed, as noted in chapter III, preliminary experiments in our lab with E. coli
that have a viral-like mutation rate suggest that resistance to base analogue mutagens can
evolve rapidly, negating any potential long-term mutagenic effects (Balk et al. in prep) Conversely, simulations of organisms with RNA virus-level mutation rates that have been
treated with a recombination-inhibiting drug suggest that the evolution of resistance to
This suggests that anti-recombinatorial drugs may be a potential candidate for the
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