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Captación del colesterol de las lipoproteínas

1. HOMEOSTASIS DEL COLESTEROL

1.2. Captación del colesterol de las lipoproteínas

In most Yb-doped alumino-silicate fiber lasers, the output wavelength is ~1.1 µm with the lowest threshold, as mentioned before, whilst the Yb-doped phospho-silicate fiber

laser can produce the laser output at a relatively shorter wavelength, which is not as

efficient as aluminosilicate host due to the limited solubility of Yb ions in the

phosposilicate host. However, the DCHOF is available to generate a laser output at the

shorter wavelength, ≤ 1.06µm by suppressing the amplified stimulated emission (ASE) at 1.1 µm using the fundamental mode cut-off. Even Raman gain at the 1st Stokes wavelength can be reduced due to the induced loss by the fundamental mode cut-off when the cut-off

wavelength is located properly between the signal and 1st order stoke wavelength [39] and the power scaling up to multi kW using single mode doped core is possible without the

The same preform as used in the previous section (LF239) was drawn to a fiber

with 170 µm inner-cladding diameter (F643-LF239) in order to move the fundamental mode cut-off to a slightly longer wavelength, and coated with a low-index polymer outer

cladding which provided a nominal inner-cladding NA of 0.48. The core comprised a 6.2

µm Yb-doped ring (NA ~ 0.07) around an air hole of 18µm diameter, and a depressed ring in the inner cladding of thickness 14 µm (NA ~ 0.08). From these fiber parameters, the modal characteristics, using the equation (4-3) in the previous chapter 4, were numerically

analyzed. Figure 5-16 (a) shows the effective indexes changes of LP01 mode depending on

the wavelength of such a fiber. The fundamental, LP01, mode cut-off is ~1.15 µm. Thus the

guided core mode does not exist beyond this wavelength. Experimentally, the cut-off

wavelength was measured with a white light transmission measurement, as shown in figure

5-16 (b), and the result is in good agreement with our modeling.

Based on the transmission spectrum, the induced loss by the fundamental mode cut-

off is around 10 dB/m, while the loss at 1040 nm was not significantly affected by the

fundamental mode cut-off. Although the bending radius was as small as 5 cm, the induced

0.7 0.8 0.9 1.0 1.1 1.2 1.4572 1.4574 1.4576 1.4578 1.4580 E ff e c ti v e i n d e x ( a .u .) Wavelength (µµµµm) LP01 mode LP11 mode 800 900 1000 1100 1200 -90 -80 -70 -60 800 1000 1200 -80 -60 Wavelength (nm) T ra n s m it te d p o w e r (d B m )

Figure 5-16. (a) Effective indexes changes of each guided mode in DCHOF (b) Spectrum of transmitted light from a tungsten filament lamp (fiber length : 1 m)

Not bent

Bending radius : 5cm

LP01 mode cut-off

(a) (b)

bending loss was 1 dB/m, which is much smaller than before. The Yb-doped DCHOF was

pumped by 975 nm multimode diode stack lasers (Laserline source with 500 W output)

through a combination of collimating lenses and dichroic mirrors. Figure 5-17 shows the

laser configuration for Yb:Al-doped DCHOF. 5 m long fiber was used and a simple laser

cavity was formed between perpendicularly cleaved end facets of the fiber, providing 4%

Fresnel reflections. Dichroic mirrors (high reflection at 980 nm, high transmission at 1030

nm) were used to separate signal and pump beams. The output power was monitored at

both sides with power meters. The operational pump absorption was 2 dB/m.

Figure 5-18 shows the laser output characteristics. The output power reached 59.1

W with a slope efficiency of 81% with respect to the launched pump power and 85% with

respect to the absorbed pump power, with a central lasing wavelength of 1046nm. The

emission at longer wavelength with low threshold was suppressed by the LP01 mode cut-

off, instead, the shorter wavelength of 1046 nm was lased in this cavity. The mode field at

the longer wavelength is not confined to the doped core and exists as the cladding mode,

which is caused to significantly reduce the overlap with the doped core significantly and

thus the gain at longer wavelengths is not enough to generate a laser. In practice, the

overlap factor at 1046nm was 61%, while it is 3% at 1080 nm according to the calculation.

In a narrow wavelength range of 34 nm, the overlap factor is reduced by a factor of 20,

Pump

@ 975 nm

Yb-doped DCHOF (5m) Laser output Residual pump Dichroic mirror HT: 975 nm HR: 1030 – 1150 nm Dichroic mirror HT: 975 nm HR: 1030 - 1150 nm

Figure 5-17. Laser configuration for Yb-doped DCHOF . HR: high reflectivity, HT: high transmission.

Perpendicularly cleaved

which means that the gain at longer wavelengths can be suppressed by a factor of 20 and it

was possible due to the steep LP01 cut-off characteristic of DCHOF. In this case, the laser

wavelength of 1046nm is quite near the fundamental mode cut-off. It can be expected that

a high loss is employed at the signal wavelength due to the fundamental mode cut-off.

However, the laser at the shorter wavelength can be achievable with such high efficiency

without any additional loss by the LP01 mode-cut-off. In addition, only the LP01 mode is

guided in this ring core at the laser wavelength of 1046nm, where the LP11 mode is cut-off

based on the modal calculation in figure 5-16 and thus, the output beam quality is expected

to be a diffraction-limited single mode, as shown in the previous results [94]. Moreover, as

the emission at longer wavelength is filtered out from the core, SRS, the main constraint on

power scaling, can be suppressed by the induced loss of the fundamental mode cut-off. In

practice, the suppression of SRS was demonstrated using W-type fiber, which has a similar

cut-off characteristic and will be discussed in details in chapter 6.

The Yb:Al-doped DCHOF thus looks promising to generate lasers over all the

emission bands of Yb ions in a silicate glass host.

1000 1020 1040 1060 1080 -80 -60 -40 -20 O u tp u t (d B m ) Wavelength (nm) (b) 0 10 20 30 40 50 60 70 0 10 20 30 40 50 60 O u tp u t p o w e r (W )

Absorbed pump power (W) Measured data Linear fit

(a)

Figure 5-18. (a) Laser output characteristics of Yb-doped DCHOF at 1046nm, (b) Laser output spectrum (OSA resolution : 2 nm)

5-3. Summary

In this chapter, an Yb:Al-doped silica DCHOF, designed with non-zero

fundamental mode cut-off, for high-power cladding-pumped 980 nm laser operation was

demonstrated. In addition, laser operation at the other shorter wavelength (1046 nm) in the

Yb:Al-doped silica DCHOF was also presented. Such fibers act as short-pass filters that

allow unwanted longer wavelengths to be suppressed.

Firstly, the requirements of a cladding-pumped 980 nm fiber laser were analyzed,

in particular the need to suppress competing emission at 1030 nm and longer wavelengths.

Then the ability of DCHOFs of different designs to satisfy these requirements was

investigated. It was found that even though the 980 nm emission in the Yb-system is quite

close to the competing emission, which normally dominates in a cladding-pumped fiber, it

is still possible to design the DCHOF to efficiently suppress the competing emission at the

longer wavelength. Experimentally, 3.1 W of output power was obtained in a nearly

diffraction limited beam (M2 1.09) in a fiber with a 120 µm inner cladding diameter, with a laser threshold of 9.2 W and a slope efficiency of 34%. Although, the large inner cladding

facilitates pumping with a low brightness pump diodes, but it leads to a high 980 nm laser

threshold. The output power increased to 7.5 W when the inner cladding diameter was

reduced to 90 µm, while keeping the core parameters constant, as a result of a lower threshold. However, at the same time, the beam quality degraded to an M2-value of 2.7. This is due to cladding-mode lasing in the thinner fiber with its larger overlap between the

cladding-modes and the core. In an improved fiber design, cladding-modes can be

suppressed by a 980 nm absorber in the cladding. The relatively low slope efficiency is

A cladding-diameter of 90 – 100 µm is still compatible with standard low-cost diode sources. Our initial result suggests that the DCHOF approach can be used for low-

cost single-mode 980 nm laser sources, with a few watts of output power, pumped by

single-emitter multimode diodes with ~ 10 W of output power. It would allow for scaling

up the power beyond 10 W with commercially available multi-diode and multi-emitter

diode sources including diode bars.

Secondly, through a simple laser characterization of the Yb:Al-doped DCHOF, the

suppression of the gain at the longer wavelength side in Yb emission bands was verified.

The DCHOF structure was useful to suppress the undesired emission at the longer

wavelength when the fiber was properly designed. 59.1W of the output power with 85%

slope efficiency with respect to the absorbed pump power at a shorter wavelength, 1046nm,

was demonstrated, by filtering out the emission at the longer wavelength (~ 1100 nm). In

addition, the high pump absorption in DCHOF was achieved due to the ring core. The

output beam is expected to be single-mode based on our modal calculation. Therefore, the

Yb-doped DCHOF shows promising prospects to scale up the output power in a single

PART IV.

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